Circulating CCN6/WISP3 in type 2 diabetes mellitus patients and its correlation with insulin resistance and inflammation: statistical and machine learning analyses

BMC Medical Informatics and Decision Making, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

Cellular Communication Network Factor 6 (CCN6) is an adipokine whose production undergoes significant alterations in metabolic disorders. Given the well-established link between obesity-induced dysfunction and development of insulin resistance type 2 diabetes mellitus (T2DM), this study investigates potential role CCN6 as a biomarker for T2DM. The present aimed to investigate association serum levels T2DM, well its risk factors, first time. In case-control study, total 80 individuals diagnosed with T2DM healthy control individuals, who referred Shariati hospital (Tehran, Iran), were included study. Biochemical parameters including fasting blood glucose (FBG), aspartate transaminase (AST), alanine (ALT), triglycerides (TG), cholesterol (TC), high-density lipoprotein (HDL), low-density (LDL) determined using AutoAnalyzer instrument. circulating CCN6, adiponectin, Tumor necrosis factor-α (TNF)-α, Interleukin (IL-6), quantified ELISA. Student t-test was applied data that presented mean ± standard deviations (SD). Moreover, Gini Index utilized determine weight each factor classification. Additionally, various machine learning models employed develop classifiers predicting patients demonstrated significantly lower (1259.76 395.02 pg/ml) compared controls (1979.17 471.99 pg/ml, P < 0.001), adiponectin (P 0.001) higher TNF-α IL-6 non-T2DM individuals. group, exhibited negative correlations insulin, Homeostatic Model Assessment Insulin Resistance (HOMA-IR), body mass index (BMI), IL-6, TNF-α. Logistic regression analysis indicated increased cutoff value 1527.95 pg/mL distinguishing 86.3% sensitivity 73.8% specificity. highlighted HOMA-IR, IL6, had highest weighting on Our research identified likelihood inflammation biomarkers (IL-6 TNF-α). shows promise T2DM; however, further investigations are necessary validate finding assess clinical utility.

Language: Английский

Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3570 - 3570

Published: April 10, 2025

Asthma and atherosclerosis are chronic conditions with distinct pathophysiologies, but overlapping inflammatory mechanisms that suggest a potential common regulatory framework. MicroRNAs (miRNAs), small non-coding RNA molecules modulate gene expression post-transcriptionally, could be key players in linking these disorders. This review outlines how miRNAs contribute to the complex interplay between asthma atherosclerosis, focusing on involved pathways, immune cell regulation vascular remodeling. We discuss specific miRNAs, such as miR-155, miR-21 miR-146a, which have been shown cytokine production T differentiation, impacting respiratory cardiovascular health. The found both emphasize their role biomarkers, also therapeutic targets. Understanding molecular connections may unlock novel approaches for innovative, integrated treatment strategies address significantly improve patient outcomes. Further research is needed explore mechanistic pathways validate translational of miRNA-based interventions preclinical clinical settings.

Language: Английский