Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study DOI Creative Commons

Ruicong Ma,

Cheng Zhang,

Jiaqing Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Background Magnesium is an essential immune nutrient for the body, and recent studies have found that it plays important role in osteoarthritis (OA). depletion score(MDS) a new method evaluating magnesium status of body. Our objective to explore association between MDS incidence OA, as well relationship mortality patients with OA. Methods Eligible participants were obtained from NHANES 2005 2018. Logistic regression models employed evaluate link Cox among OA patients. In addition, restricted cubic spline was utilized correlation Subgroup analysis adopted order ensure credibility results different subgroups, including age, gender, race, education level, BMI, smoking, diabetes hypertension. Results 19,394 individuals qualified analysis, 3,256 After excluding missing follow-up data, 630 all-cause deaths 172 cardiovascular (CVDs) observed 3,250 The had higher levels MDS. logistic model, positively related (MDS≥3 vs. MDS=0, OR =1.83 (1.46-2.30, P <0.001)). Besides, positive [MDS≥3 HR =2.56 (1.49-4.41, <0.001)] CVDs =3.00 (1.13-7.98, =0.01)] cox models. 1-unit rise significantly linked increased risk mortality. Restricted indicated demonstrated are stable subgroups. Conclusions correlated Optimizing nutritional may bring benefits

Language: Английский

Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study DOI Creative Commons

Ruicong Ma,

Cheng Zhang,

Jiaqing Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Background Magnesium is an essential immune nutrient for the body, and recent studies have found that it plays important role in osteoarthritis (OA). depletion score(MDS) a new method evaluating magnesium status of body. Our objective to explore association between MDS incidence OA, as well relationship mortality patients with OA. Methods Eligible participants were obtained from NHANES 2005 2018. Logistic regression models employed evaluate link Cox among OA patients. In addition, restricted cubic spline was utilized correlation Subgroup analysis adopted order ensure credibility results different subgroups, including age, gender, race, education level, BMI, smoking, diabetes hypertension. Results 19,394 individuals qualified analysis, 3,256 After excluding missing follow-up data, 630 all-cause deaths 172 cardiovascular (CVDs) observed 3,250 The had higher levels MDS. logistic model, positively related (MDS≥3 vs. MDS=0, OR =1.83 (1.46-2.30, P <0.001)). Besides, positive [MDS≥3 HR =2.56 (1.49-4.41, <0.001)] CVDs =3.00 (1.13-7.98, =0.01)] cox models. 1-unit rise significantly linked increased risk mortality. Restricted indicated demonstrated are stable subgroups. Conclusions correlated Optimizing nutritional may bring benefits

Language: Английский

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