Associations of modified triglyceride-glucose indices and the triglyceride/high-density lipoprotein ratio with all-cause and cause-specific mortality in the general population: an analysis of the UK biobank database DOI Creative Commons

Zihao Zhang,

Haihua Guo,

Zhen Sun

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 1, 2025

This study investigates the associations between modified triglyceride-glucose (TyG) indices and triglyceride-to-high-density lipoprotein (TG/HDL) ratio, which are recognized as simple surrogate indicators of insulin resistance, with all-cause cause-specific mortality. A cohort 410,515 participants from UK Biobank was analyzed. Cox proportional hazard models restricted cubic spline regression analyses were employed to examine relationships TyG index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TG/HDL Structural equation modeling elucidate inflammation, metabolism, The TyG-WC, ratio associated an increased risk mortality by 3.7% (HR 1.037 [1.016, 1.059]), 0.1% 1.001 [1.024, 1.031]), 1.5% 1.015 [1.006, 1.025]), respectively. Restricted revealed nonlinear trends in TyG-BMI, relation both (P for nonlinearity < 0.05). exhibited a J-shaped relationship well cancer, cardiovascular diseases, respiratory diseases. Similarly, TyG-BMI demonstrated L-shaped association due Additionally, TyG-WC progressively increasing once it exceeded certain threshold. that influenced through inflammation lifestyle factors. In conclusion, TyG, significantly general population.These appear be linked lifestyle.

Language: Английский

Associations of modified triglyceride-glucose indices and the triglyceride/high-density lipoprotein ratio with all-cause and cause-specific mortality in the general population: an analysis of the UK biobank database DOI Creative Commons

Zihao Zhang,

Haihua Guo,

Zhen Sun

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 1, 2025

This study investigates the associations between modified triglyceride-glucose (TyG) indices and triglyceride-to-high-density lipoprotein (TG/HDL) ratio, which are recognized as simple surrogate indicators of insulin resistance, with all-cause cause-specific mortality. A cohort 410,515 participants from UK Biobank was analyzed. Cox proportional hazard models restricted cubic spline regression analyses were employed to examine relationships TyG index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TG/HDL Structural equation modeling elucidate inflammation, metabolism, The TyG-WC, ratio associated an increased risk mortality by 3.7% (HR 1.037 [1.016, 1.059]), 0.1% 1.001 [1.024, 1.031]), 1.5% 1.015 [1.006, 1.025]), respectively. Restricted revealed nonlinear trends in TyG-BMI, relation both (P for nonlinearity < 0.05). exhibited a J-shaped relationship well cancer, cardiovascular diseases, respiratory diseases. Similarly, TyG-BMI demonstrated L-shaped association due Additionally, TyG-WC progressively increasing once it exceeded certain threshold. that influenced through inflammation lifestyle factors. In conclusion, TyG, significantly general population.These appear be linked lifestyle.

Language: Английский

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