Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22
Published: Nov. 29, 2024
Language: Английский
Results in Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 104370 - 104370
Published: Feb. 1, 2025
Language: Английский
Citations
3
Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)
Published: April 11, 2024
Abstract The epigenome—the chemical modifications and chromatin-related packaging of the genome—enables same genetic template to be activated or repressed in different cellular settings. This multi-layered mechanism facilitates cell-type specific function by setting local sequence 3D interactive activity level. Gene transcription is further modulated through interplay with factors co-regulators. human body requires this epigenomic apparatus precisely installed throughout development then adequately maintained during lifespan. causal role epigenome pathology, beyond imprinting disorders tumour suppressor genes, was brought into spotlight large-scale sequencing projects identifying that mutations machinery genes could critical drivers both cancer developmental disorders. Abrogation providing new molecular insights pathogenesis. However, deciphering full breadth implications these changes remains challenging. Knowledge accruing regarding disease mechanisms clinical biomarkers, pathogenically relevant surrogate tissue analyses, respectively. Advances include consortia generated reference epigenomes, high-throughput DNA methylome association studies, as well ageing-related diseases from biological ‘clocks’ constructed machine learning algorithms. Also, 3rd-generation beginning disentangle complexity modification haplotypes. Cell-free methylation a biomarker has clear utility potential assess organ damage across many Finally, understanding aetiology brings it opportunity for exact therapeutic alteration CRISPR-activation inhibition.
Language: Английский
Citations
10
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: March 29, 2024
Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis and responsible for the quality control of proteins, organelles, energy metabolism. The E1-like ubiquitin-activating enzyme autophagy-related gene 7 (ATG7) critical factor initiates classic autophagy reactions by promoting formation extension autophagosome membranes. Recent studies have identified key functions ATG7 in regulating cycle, apoptosis, metabolism associated with occurrence development multiple diseases. This review summarizes how precisely programmed genetic, transcriptional, epigenetic modifications cells relationship between aging-related
Language: Английский
Citations
9
Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)
Published: Nov. 13, 2024
Abstract With the increasing demand for precision medicine in cancer patients, radiogenomics emerges as a promising frontier. Radiogenomics is originally defined methodology associating gene expression information from high‐throughput technologies with imaging phenotypes. However, advancements medical imaging, omics technologies, and artificial intelligence, both concept application of have significantly broadened. In this review, history enumerated, related five basic workflows their applications across tumors, role AI radiogenomics, opportunities challenges tumor heterogeneity, immune microenvironment. The positron emission tomography multi‐omics studies also discussed. Finally, faced by clinical transformation, along future trends field
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142471 - 142471
Published: March 1, 2025
Language: Английский
Citations
0
Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(22)
Published: Nov. 20, 2023
Coronary heart disease (CHD) is the leading cause of death in world. Unfortunately, many key diagnostic tools for CHD are insensitive, invasive, and costly; require significant specialized infrastructure investments; do not provide information to guide postdiagnosis therapy. In prior work using data from Framingham Heart Study, we provided silico evidence that integrated genetic-epigenetic may a new avenue assessing CHD.
Language: Английский
Citations
10
Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Background Genome‐wide association studies have revealed numerous loci associated with coronary artery disease (CAD). However, some potential causal/risk genes remain unidentified, and causal therapies are lacking. Methods Results We integrated multi‐omics data from gene methylation, expression, protein levels using summary data‐based Mendelian randomization colocalization analysis. Candidate were prioritized based on protein‐level associations, probability, links to methylation expression. Single‐cell RNA sequencing used assess differential expression in the arteries of patients CAD. TAGLN2 ( Transgelin 2 ), APOB Apolipoprotein B GIP Glucose‐dependent insulinotropic polypeptide ) identified as most strongly CAD, exhibiting significant association. Higher at specific Cytosine‐phosphate‐Guanine sites negatively correlated its a lower risk whereas higher circulating positively CAD (odds ratio,1.66 [95% CI, 1.32–2.08). These results suggest distinct regulatory mechanisms for . In contrast, showed positive associations risk, DHX58 DExH‐box helicase 58 SWAP70 Switch‐associated 70 decreased risk. Conclusions Our findings provide evidence suggesting that , This work provides novel insights into molecular highlights integrating uncover relationships cannot be fully captured by traditional genome‐wide studies.
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 2, 2025
The global burden of cardiovascular diseases continues to rise, making their prevention, diagnosis and treatment increasingly critical. With advancements breakthroughs in omics technologies such as high-throughput sequencing, multi-omics approaches can offer a closer reflection the complex physiological pathological changes body from molecular perspective, providing new microscopic insights into research. However, due vast volume complexity data, accurately describing, utilising, translating these biomedical data demands substantial effort. Researchers clinicians are actively developing artificial intelligence (AI) methods for data-driven knowledge discovery causal inference using various data. These AI approaches, integrated with research, have shown promising outcomes studies. In this review, we outline integrating machine learning, one most successful applications AI, summarise representative models developed that leverage facilitate exploration underlying mechanisms clinical practice. Particular emphasis is placed on effectiveness extract potential information address current gaps. We discuss challenges opportunities routine diagnostic therapeutic practices anticipate future development novel wider application field diseases.
Language: Английский
Citations
0
Opto-Electronic Advances, Journal Year: 2025, Volume and Issue: 0(0), P. 240254 - 240254
Published: Jan. 1, 2025
Language: Английский
Citations
0
Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23
Published: Jan. 1, 2024
As an important nutrient in the human body, cholesterol can not only provide structural components for body's cells, but also be transformed into a variety of active substances to regulate cell signaling pathways. synthase, DHCR24 participates regulatory processes body. The application tumor clinical diagnosis and treatment attracts much attention. This article reviews structure characteristics DHCR24, research on progression. We summarize possible mechanisms promoting progression through reactive oxygen species (ROS), p53, Ras PI3K-AKT Through our review, we hope more ideas reference value prevention treatment.
Language: Английский
Citations
3