Computer reconstruction of gene networks controlling anxiety levels in humans and laboratory mice

Vavilov Journal of Genetics and Breeding, Journal Year: 2025, Volume and Issue: 29(1), P. 162 - 170

Published: March 4, 2025

Anxiety is a normotypic human condition, and like any other emotion has an adaptive value. But excessively high or low anxiety negative consequences for adaptation, which primarily determines the importance of studying these two extreme conditions. At same time, it known that perception aversive stimuli associated with leads to changes in activity brain’s cingulate cortex. The advantage animals as models genetic bases humans ability subtly control external conditions formation certain state, availability brain tissues, create study transgenic models, including through use differentially expressed genes small laboratory from family Muridae anxiety. Within framework translational approach, three-domain potential gene network, generalized humans, was reconstructed using mouse different levels by automatically analyzing texts scientific articles. One domain reduced second increased anxiety, third dispatcher who activates one domains depending on status organism (genetic, epigenetic, physiological). Stages work: (I) A list cortex wild type CD-1 line NCBI GEO database (experiment GSE29014). Using tools this database, differences expression were revealed groups mice (relatively normal) (II) Search orthologs DEG OMA Orthology database. (III) Computer reconstruction ANDSystem cognitive system based (a) orthologous stage (III), (b) MalaCards proven methods approach networks behavior regulation can be used identify molecular markers personality traits, propensity psychopathology.

Language: Английский

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Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 3, 2025

Abstract Depressive disorders result from complex interactions among genetic, epigenetic, and environmental factors. DNA methylation, a key epigenetic mechanism, is crucial in understanding depressive symptoms development. The serotonin transporter gene ( 5-HTT ) its polymorphisms, like 5-HTTLPR , have been extensively studied relation to depression, yet conflicting findings regarding the association between promoter methylation persist, largely due methodological differences. Thus, this systematic review meta-analysis aims assess (1) levels depressed non-depressed conditions (2) severity. We searched PubMed, Google Scholar, Web of Science inception January 15th, 2025 (PROSPERO: CRD42023355414) performed two independent multi-level meta-analyses answer our aims. Twenty-four trials were included review. All reported effects carried potential for bias. depression occurrence (12 studies - 2028 subjects – 127 effects) indicated no significant effect (Hedges’g = 0.06) with moderate within- low between-study heterogeneity. severity analysis (14 2296 116 revealed null size (Fisher’s Z 0.05), Asymmetry was detected both meta-analyses. Moderator analyses demonstrated severity, techniques, single-CpG sites, cell types assessed, age, female percentage. This comprehensive provides insights into intricate interplay symptoms. Furthermore, it offers well-considered recommendations future research endeavors delineates guidelines reporting research.

Language: Английский

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DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. 111160 - 111160

Published: Oct. 1, 2024

Language: Английский

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Peripheral DNA methylation of cortisol- and serotonin-related genes predicts hippocampal volume in a pediatric population

Biological Psychiatry Global Open Science, Journal Year: 2024, Volume and Issue: 5(2), P. 100421 - 100421

Published: Nov. 26, 2024

Language: Английский

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