Epigenetic age and long-term cancer risk following a stroke DOI Creative Commons
Antoni Suárez‐Pérez, Adrià Macias-Gómez, Isabel Fernández

et al.

Genome Medicine, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 22, 2024

The association between increased cancer risk following a cerebrovascular event (CVE) has been previously reported. We hypothesize that biological age (B-age) acceleration is involved in this association. Our study aims to examine B-age as novel contributing factor development post-CVE. From our prospective stroke registry (BasicMar), we selected 940 cases with epigenetic data. For study, specifically analyzed 648 of these patients who had available data, no prior history cancer, and minimum follow-up 3 months. primary outcome was incidence. estimated using DNA methylation data derived from whole blood samples obtained within 24 h onset, employing various clocks (including Hannum, Horvath, PhenoAge, ZhangBLUP, ZhangEN, the mitotic epiTOC). Extrinsic (EEAA) calculated residuals regression against chronological (C-age). epiTOC, age-adjusted values were by regressing out effect raw epiTOC measurements. Estimated white cell counts fractions used compute intrinsic (IEAA). Subsequently, evaluated independent EEAA, IEAA, incidence while controlling for potential confounding variables. Among median 8.15 years, 83 (12.8%) developed cancer. Cox multivariable analyses indicated significant associations Zhang, EEAA after CVE. After adjusting multiple testing competing risks, measured Hannum clock maintained an risk. Specifically, each year increase Hannum's observed 6.0% (HR 1.06 [1.02–1.10], p value = 0.002). findings suggest accelerated aging, may play role CVE survivors.

Language: Английский

Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke DOI Creative Commons
Huaqiang Li, Xiaohua Ke, Bainian Feng

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Post-stroke cognitive impairment (PSCI) is a common complication following stroke that significantly affects patients’ quality of life and rehabilitation outcomes. It also imposes heavy economic burden. There an urgent need to better understand the pathophysiology pathogenesis PSCI, as well identify markers can predict PSCI early in clinical stage, facilitating prevention, monitoring, treatment. Although mechanisms underlying are complex multifaceted, involving factors such atherosclerosis neuroinflammation, metabolic disorders play critical role. This article primarily reviews relationship between three major nutrients—sugar, fat, protein—and development dysfunction ischemic (IS). aims elucidate how these disturbances contribute post-stroke explore potential biomarkers for PSCI. We believe this review will offer new insights into identification, treatment, prognostic assessment

Language: Английский

Citations

2
Recent Advances in Stroke Genetics—Unraveling the Complexity of Cerebral Infarction: A Brief Review DOI Open Access
Takeshi Yoshimoto,

Hiroshi Yamagami,

Yuji Matsumaru

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(1), P. 59 - 59

Published: Jan. 6, 2025

Recent advances in stroke genetics have substantially enhanced our understanding of the complex genetic architecture underlying cerebral infarction and other subtypes. As knowledge this field expands, healthcare providers must remain informed about these latest developments. This review aims to provide a comprehensive overview recent genetics, with focus on infarction, discuss their potential impact patient care future research directions. We reviewed literature focusing discussed Key developments include identification monogenic syndromes, such as autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy, recessive leukoencephalopathy caused by mutations NOTCH3 HTRA1 genes, respectively. In addition, role RNF213 moyamoya disease cerebrovascular disorders, particularly East Asian populations, has been elucidated. The development polygenic risk scores for assessing predisposition demonstrated improve prediction beyond traditional factors. Genetic studies also elucidated distinct subtypes, including large artery atherosclerosis, small vessel disease, cardioembolic stroke. Furthermore, investigation epigenetic modifications influencing its outcomes revealed new avenues, while advancements pharmacogenomics highlight personalized treatment based individual profiles. These discoveries important clinical implications, improved stratification, targeted prevention strategies, novel therapeutic approaches.

Language: Английский

Citations

0
How epigenetics impacts stroke risk and outcomes through DNA methylation: A systematic review DOI
Cristina Gallego‐Fabrega, Natàlia Cullell, Israel Fernández‐Cadenas

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The impact of DNA methylation (DNAm) on epigenetics has gained prominence in recent years due to its potential influence ischemic stroke (IS) and treatment outcomes. DNAm is reversible a better understanding role IS could help identify novel therapeutic targets. aim this systematic review was compile the available data risk prognosis explore potential. process followed PRISMA criteria. We searched Pubmed Cochrane databases studies that used hypothesis free methodological approaches. Of 459 identified, 34 met inclusion were categorized as follows: IS; outcomes; age. Most genotyping array technology rather than whole-genome sequencing. testing mainly based blood samples. involved European cohorts. performed at single-center with recruitment time stroke. In few studies, health status determined longitudinally. This shows patients are biologically older expected present characteristic patterns related These be develop new treatments epidrugs.

Language: Английский

Citations

0
Genomics of stroke recovery and outcome DOI
Arne Lindgren

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

The understanding of genomics has improved tremendously during the last decades. concept recovery and outcome after stroke also progressed this time. However, connection between only begun to emerge in a more structural comprehensive way. Different types outcomes occur stroke. This depends on domain neurological deficit, severity, resilience, receptivity for rehabilitation measures, concomitant morbidity. Methods assessing patients’ prognosis depend these factors. genetic approaches are possible there is an increasing need linking findings other omics as well clinically meaningful results. review addresses recent advances views clinical humans with focus current previous studies, concepts, future perspectives.

Language: Английский

Citations

0
Epigenetic age and long-term cancer risk following a stroke DOI Creative Commons
Antoni Suárez‐Pérez, Adrià Macias-Gómez, Isabel Fernández

et al.

Genome Medicine, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 22, 2024

The association between increased cancer risk following a cerebrovascular event (CVE) has been previously reported. We hypothesize that biological age (B-age) acceleration is involved in this association. Our study aims to examine B-age as novel contributing factor development post-CVE. From our prospective stroke registry (BasicMar), we selected 940 cases with epigenetic data. For study, specifically analyzed 648 of these patients who had available data, no prior history cancer, and minimum follow-up 3 months. primary outcome was incidence. estimated using DNA methylation data derived from whole blood samples obtained within 24 h onset, employing various clocks (including Hannum, Horvath, PhenoAge, ZhangBLUP, ZhangEN, the mitotic epiTOC). Extrinsic (EEAA) calculated residuals regression against chronological (C-age). epiTOC, age-adjusted values were by regressing out effect raw epiTOC measurements. Estimated white cell counts fractions used compute intrinsic (IEAA). Subsequently, evaluated independent EEAA, IEAA, incidence while controlling for potential confounding variables. Among median 8.15 years, 83 (12.8%) developed cancer. Cox multivariable analyses indicated significant associations Zhang, EEAA after CVE. After adjusting multiple testing competing risks, measured Hannum clock maintained an risk. Specifically, each year increase Hannum's observed 6.0% (HR 1.06 [1.02–1.10], p value = 0.002). findings suggest accelerated aging, may play role CVE survivors.

Language: Английский

Citations

0