The predictive power of profiling the DNA methylome in human health and disease DOI Creative Commons
Paraskevi Christofidou, Christopher G. Bell

Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: May 10, 2025

Early and accurate diagnosis significantly improves the chances of disease survival. DNA methylation (5mC), major modification in human genome, is now recognized as a biomarker immense clinical potential. This due to its ability delineate precisely cell-type, quantitate both internal external exposures, well tracking chronological biological components aging process. Here, we survey current state predictor traits disease. includes Epigenome-wide association study (EWAS) findings that inform Methylation Risk Scores (MRS), EpiScore long-term estimators plasma protein levels, machine learning (ML) derived clocks. These all highlight significant benefits accessible peripheral blood surrogate measure. However, detailed biopsy analysis real-time also empowering pathological diagnosis. Furthermore, moving forward, this multi-omic biobank scale era, novel insights will be enabled by amplified power increasing sample sizes data integration.

Language: Английский

The predictive power of profiling the DNA methylome in human health and disease DOI Creative Commons
Paraskevi Christofidou, Christopher G. Bell

Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: May 10, 2025

Early and accurate diagnosis significantly improves the chances of disease survival. DNA methylation (5mC), major modification in human genome, is now recognized as a biomarker immense clinical potential. This due to its ability delineate precisely cell-type, quantitate both internal external exposures, well tracking chronological biological components aging process. Here, we survey current state predictor traits disease. includes Epigenome-wide association study (EWAS) findings that inform Methylation Risk Scores (MRS), EpiScore long-term estimators plasma protein levels, machine learning (ML) derived clocks. These all highlight significant benefits accessible peripheral blood surrogate measure. However, detailed biopsy analysis real-time also empowering pathological diagnosis. Furthermore, moving forward, this multi-omic biobank scale era, novel insights will be enabled by amplified power increasing sample sizes data integration.

Language: Английский

Citations

0