Advances in neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 757 - 799
Published: Jan. 1, 2024
Language: Английский
Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 101, P. 101273 - 101273
Published: May 15, 2024
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of Alzheimer's disease (AD). Studies have identified the pathological hallmarks AD, including amyloid β-protein (Aβ) deposits abnormal tau protein isoforms, in retinas AD patients animal models. Moreover, structural functional vascular abnormalities such as reduced blood flow, Aβ deposition, blood-retinal barrier damage, along with inflammation neurodegeneration, been described mild cognitive impairment dementia. Histological, biochemical, clinical studies demonstrated that nature severity pathologies brain correspond. Proteomics analysis revealed a similar pattern dysregulated proteins biological pathways patients, enhanced inflammatory neurodegenerative processes, impaired oxidative-phosphorylation, mitochondrial dysfunction. Notably, investigational imaging technologies can now detect AD-specific deposits, well vasculopathy neurodegeneration living suggesting alterations at different stages links to pathology. Current exploratory ophthalmic modalities, optical coherence tomography (OCT), OCT-angiography, confocal scanning laser ophthalmoscopy, hyperspectral imaging, may offer promise assessment AD. However, further research needed deepen our understanding AD's impact on its progression. To advance this field, future require replication larger diverse cohorts confirmed biomarkers standardized retinal techniques. This will validate aiding early screening monitoring.
Language: Английский
Citations
25
Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 20(1), P. 728 - 740
Published: Nov. 2, 2023
Abstract There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the retina are associated with Alzheimer's disease (AD). Aβ hyperphosphorylated (p)‐tau deposits have been described were small spots visualized by vivo imaging techniques as well degeneration of retina. These changes correlate brain deposition determined histological quantification, positron emission tomography (PET) or clinical diagnosis AD. However, literature not coherent on these histopathological findings. One important reason for this variability methods interpretation findings across different studies. In perspective, we indicate critical methodological deviations among groups suggest a roadmap moving forward how to harmonize (i) histopathologic examination retinal tissue; (ii) methods, devices, algorithms; (iii) inclusion/exclusion criteria studies aiming at biomarker validation.
Language: Английский
Citations
28
Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 122 - 122
Published: Jan. 9, 2025
Alzheimer's disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that profoundly impacts cognitive function and nervous system. Emerging evidence highlights pivotal roles iron homeostasis dysregulation microbial inflammatory factors in oral gut microbiome as potential contributors to pathogenesis AD. Iron disruption can result excessive intracellular accumulation, promoting generation reactive oxygen species (ROS) oxidative damage. Additionally, agents produced by pathogenic bacteria may enter body via two primary pathways: directly through or indirectly cavity, entering bloodstream reaching brain. This infiltration disrupts cellular homeostasis, induces neuroinflammation, exacerbates AD-related pathology. Addressing these mechanisms personalized treatment strategies target underlying causes AD could play critical role preventing its onset progression.
Language: Английский
Citations
0
NeuroImage Clinical, Journal Year: 2025, Volume and Issue: 45, P. 103760 - 103760
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Background Structural changes in medial temporal lobes including the fusiform gyrus, a critical area face recognition, precede progression of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). However, how neural correlates processing altered aMCI, as well their association with impairments, remain unclear. Objective Using electroencephalogram (EEG), we explored electrophysiological markers face-specific visual alterations aMCI and examined relationship deficits. Methods We recruited participants (n = 32) healthy controls (HC, n 41) used passive viewing task measure event-related potential (ERP) response faces non-face objects. To compare patients HCs, adopted mass univariate analysis representational similarity (RSA) explore aMCI-related ERPs. Results found that inversion effect (FIE) P1 amplitudes was absent patients. Also, compared exhibited lack right hemisphere advantage N170 faces. Furthermore, representation ERP posterior-temporal regions revealed represent objects distinctively from HCs early stage. Additionally, FIE amplitude positively correlated patients’ visuospatial functions. Conclusions These findings showed perceptual highlights patterns over occipital-temporal for AD.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 30, 2024
Abstract Subjective cognitive decline (SCD), mild impairment (MCI), or severe Alzheimer’s disease stages are still lacking clear electrophysiological correlates. In 178 individuals (119 SCD, 40 MCI, and 19 healthy subjects (HS)), we analysed event-related potentials recorded during a sustained visual attention task, aiming to distinguish biomarkers associated with clinical conditions task performance. We observed condition-specific anomalies in (ERPs) encoding (P1/N1/P2) decision-making (P300/P600/P900): SCD showed attenuated dynamics compared HS, while MCI amplified dynamics, except for P300, which matched severity. ERP features confirmed non-monotonic trend, showing higher neural resource recruitment. Moreover, performance correlated gain latencies across early late components. These findings enhanced the understanding of mechanisms underlying suggested potential diagnosis intervention. Highlights decision (P600/P900) ERPs, exhibited SCD. P300 demonstrated recruitment resources, indicating trend between conditions. Task multiple
Language: Английский
Citations
2
Sensors, Journal Year: 2024, Volume and Issue: 24(11), P. 3543 - 3543
Published: May 30, 2024
Amnestic mild cognitive impairment (aMCI) is a transitional stage between normal aging and Alzheimer’s disease, making early screening imperative for potential intervention prevention of progression to disease (AD). Therefore, there demand research identify effective easy-to-use tools aMCI screening. While behavioral tests in virtual reality environments have successfully captured features related instrumental activities daily living screening, further investigations are necessary establish connections decline neurological changes. Utilizing electroencephalography with steady-state visual evoked potentials, this study delved into the correlation recorded during obtained by measuring neural activity dorsal stream. As result, multimodal approach achieved an impressive accuracy 98.38%.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1706 - 1706
Published: Aug. 1, 2024
This study explored the link between different types of glaucoma and cognitive function in a cohort 620 Japanese patients. Participants were categorized into primary open-angle (PG), exfoliation (EG), non-glaucomatous control groups. The findings revealed significant decline as indicated by Mini-Cog test EG group (mean ± SD: 4.0 1, 95% CI: 3.9 to 4.2) compared PG (4.4 0.1, 4.3 4.5,
Language: Английский
Citations
1
IEEE Access, Journal Year: 2024, Volume and Issue: 12, P. 172101 - 172114
Published: Jan. 1, 2024
Language: Английский
Citations
1
Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)
Published: Oct. 10, 2024
The retina plays a crucial role in processing and decoding visual information, both normal development during myopia progression. Recent advancements have introduced library-independent approach for data-independent acquisition (DIA) analyses. This study demonstrates deep proteome identification quantification individual mice retinas development, with an average of 6,263 ± 86 unique protein groups. We anticipate that the use predicted retinal-specific spectral library combined robust achieved within this dataset will contribute to better understanding complexity. Furthermore, comprehensive was generated, encompassing total 9,401 groups, 70,041 peptides, 95,339 precursors, 761,868 transitions acquired using SWATH-MS on ZenoTOF 7600 mass spectrometer. surpasses generated through high-pH reversed-phase fractionation by data-dependent (DDA). data is available via ProteomeXchange identifier PXD046983. It also serve as indispensable reference investigations research other retinal or neurological diseases.
Language: Английский
Citations
1