Vestnik Moskovskogo universiteta Seria 16 Biologia, Journal Year: 2024, Volume and Issue: 79(№4, 2024), P. 315 - 321
Published: Jan. 1, 2024
Systemic chronic inflammation (SCI) can develop due to diabetes mellitus, coronary artery disease, atherosclerosis, autoimmune diseases, kidney, liver, and lung pathologies, cancer, etc. During the COVID-19 pandemic, there was clear evidence showing that damages endothelial cells of vascular wall, leading impaired microcirculation. Currently, mechanisms causing pathological changes in brain amid SCI are still unclear. In this work, we investigated how systemic affects vasodilatory function cerebral arteries. modeled using well-established cecal ligation puncture model, which involves tying off cecum below ileocecal valve puncturing it with a needle. For characterizing model animals, recorded body weight, blood pressure, analyzed levels leukocytes, ESR, hematocrit, erythrocyte aggregation arterial blood, number desquamated venous blood. The density network pial membrane reactivity studied vivo microvascular imaging. vessels per unit area diameter under influence vasoactive substances – aminoguanidine (an inducible NO-synthase inhibitor) acetylcholine were measured. From 7 days 3 months after onset SCI, leukocyte rat increased by 2.1–1.7 times compared control group. 1.8 control. Erythrocyte rose an average 1.3 times. decreased 1.7 constrictions arteries induced 1.5 3.7 expanded response 4.9 Thus, over period three leads decrease deterioration vasomotor
Language: Английский
