Patient Education and Counseling, Journal Year: 2024, Volume and Issue: 129, P. 108397 - 108397
Published: Aug. 14, 2024
Language: Английский
Current Research in Biotechnology, Journal Year: 2025, Volume and Issue: 9, P. 100280 - 100280
Published: Jan. 1, 2025
Language: Английский
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Journal of Insurance Medicine, Journal Year: 2025, Volume and Issue: 52(1), P. 14 - 20
Published: March 6, 2025
Type 2 diabetes and Alzheimer's dementia represent important health challenges in our society today. Understanding the relationship between these conditions is crucial. This article explores research on whether they share common risk factors or if may influence each other's development, which could lead to more effective prevention treatment strategies.
Language: Английский
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The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100130 - 100130
Published: March 1, 2025
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by amyloid-β (Aβ), tau hyperphosphorylation and neurodegeneration. Blood-based biomarkers are emerging as minimally invasive tool for detection monitoring. This review depicts the relationships between modifiable lifestyle factors (nutrition, physical activity (PA), sleep, alcohol consumption, smoking, social isolation) plasma of AD: Aβ42, Aβ40, Aβ42/40, phosphorylated tau, total neurofilament light chain (NfL) glial fibrillary acidic protein. Limited evidence suggests that better nutrition associated with favourable AD biomarker profiles PA less NfL Aβ, whilst poor sleep elevated Aβ. However, lack data inconsistent findings highlight need further investigation to substantiate or refute these trends. Moreover, future research should include analysis on according gender, metabolic health APOE status. Considering growing emphasis preventing delaying dementia onset justified.
Language: Английский
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0
Published: March 1, 2025
Language: Английский
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Qualitative Health Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
Self-management interventions are becoming more prevalent for individuals aiming to prevent dementia. However, the effectiveness of this approach is heavily shaped by health beliefs. This study seeks investigate Chinese older adults’ knowledge and beliefs about dementia prevention examine unique characteristics transformations culture with their associated implications. These insights aim inform development effective strategies. Using informed grounded theory approach, guided belief model, we conducted semi-structured interviews 42 adults. The conceptual framework centered on three themes, allowing identification both barriers facilitators prevention. factors reflect cultural influences prevention, including positive transformations: decline traditional superstitions, emergence modern scientific thinking, shift from negative aging paradigms, growing acceptance digital technologies among At same time, elements—such as aversion illness, fear death, importance placed “mianzi”—persist in reinforcing stigma Moreover, collectivist values exert dual influences, facilitating inhibiting individual behaviors.
Language: Английский
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Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
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Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13
Published: April 4, 2025
Background Ayurveda is an ancient Indian medicinal system that uses plants for their neuroprotective effects. claims the ( C. halicacabum ) leaves possess significant properties. Alzheimer’s characterized by accumulation of amyloid-β, acetylcholinesterase, and tau tangles interfere with neural transmission impair cognitive abilities. Objectives This study aimed to identify novel potential anti-Alzheimer phytoconstituents using in silico methods. Methods utilized Box–Behnken design within response surface methodology (RSM) optimize combine effects process variables, namely powder weight, solvent volume, extraction time, on microwave-assisted (MAE) leaves. The optimization revealed these along microwave usage, significantly influenced yield. ethanolic extract was examined gas chromatography-mass spectrometry (GC–MS) analysis, identified were further analyzed through computer-based simulations, including docking, absorption, distribution, metabolism, excretion, toxicity (ADMET) studies, assessment drug-likeness, molecular dynamics, LigPlot density functional theory (DFT) analysis. Results Gas (GC-MS) analysis 40 37 successfully characterized. Molecular docking dynamics simulations two lead compounds, acetic acid (dodecahydro-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-2(1H)-phenanthrenylidene)-,2-(dimethylamino)ethyl ester, [1R-(1. alpha)], 1-(2-hydroxyethoxy)-2-methyldodecane, which exhibited superior stability docked complex compared galantamine. Conclusion Based computational predictions observed pharmacological properties, findings suggest may have therapeutic against selected AD targets.
Language: Английский
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NeuroTransmitter, Journal Year: 2025, Volume and Issue: 36(2), P. 34 - 35
Published: April 1, 2025
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BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 17, 2025
A healthy lifestyle has been shown to mitigate cognitive decline in patients with mild impairment, family caregivers playing a pivotal role the patients' management. Exploring level of dementia risk reduction and influencing factors at both patient caregiver levels impairment is crucial for identifying strategies improve lifestyles delay disease progression. Using convenience sampling method, 302 their admitted neurology departments four tertiary care hospitals China, from December 2024 February 2025 were recruited surveyed using general information questionnaire, Dementia Risk Reduction Lifestyle Scale (DRRLS), Motivation Change Health Behaviors scale (MCLHB-DRR), Perceived Social Support (PSSS), Mutuality (MS). Multiple linear regression was used analyze patients. DRRLS score 83.61 ± 16.13, multiple showed that patient's monthly individual income, presence chronic disease, health beliefs, social support independent influences on lifestyle. Furthermore, mutuality also The final model explained 75.5% variance Patients have characteristics collectively influence Healthcare providers should conduct early dyadic assessments develop targeted intervention based help them
Language: Английский
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American Journal of Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 19, 2025
The field of psychiatry has evolved over the past 2500 years. Between dynamic psychotherapy and psychopharmacology, lifestyle holds a different space. This approach capitalizes on medicine movement, as it promotes change within 6 domains activity. Apart from incorporating these pillars adjunctive therapy for either psychodynamic or psychotropic medication regimens, is frontier similar to other growing fields precision psychiatry, advanced learning in psychedelics digital mental health, psychiatric genetics. Any disruption into historical practice particularly with prescription medications, can be met scrutiny. We encourage keep an open mind our continues evolve. What makes powerful unique its ability assess evaluate internal external factors that contribute individual behaviors, may impact incorporate healthy actions. Internal include: emotional regulation, internalized trauma, cognitive factors, personality traits. On hand, include environmental barriers work-related burnout.
Language: Английский
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