The associations between fresh vegetable and fruit consumption and plasma and PET biomarkers in preclinical Alzheimer's disease: A cross-sectional and longitudinal study of Chinese population DOI Creative Commons
Heling Chu, Chuyi Huang, Fang Xie

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100076 - 100076

Published: Jan. 1, 2025

The identification of the modifiable lifestyle factors including dietary habits in older adults preclinical Alzheimer's disease (AD) and early effective interventions are great importance. We studied whether consumption fresh vegetables fruits was different between cognitively unimpaired (CU) impaired (CI) population mainly investigated associations vegetable fruit PET plasma AD biomarkers CU with higher β-amyloid (Aβ) burden. Older age 50-85 years were enrolled for a cross-sectional longitudinal study. groups depended on participants or CI. Partial whose remained unchanged followed up. data collected using validated self-reported questionnaire. various positive 18F-florbetapir scan (Aβ-PET), part whom also underwent tests 18F-MK6240 (tau-PET). Correlation multiple linear regression analyses used to investigate biomarkers. A total 1433 enrolled, which accounted 49.4 %. Most intake CI participants. 177 Aβ-PET selected following Multiple analysis showed (>200 g/d), dark (>100 g/d, ≥2d/week), berries g/d) grapes more less had Aβ40, t-Tau, p-Tau-181 neurofilament light chain as well amyloid Tau associated change cognitive function after an approximately two-year follow-up. Especially, intakes correlated both lower Aβ burden inversely decline Our indicates that vegetables, fruits, is changes Higher may be helpful reducing risk development.

Language: Английский

The associations between fresh vegetable and fruit consumption and plasma and PET biomarkers in preclinical Alzheimer's disease: A cross-sectional and longitudinal study of Chinese population DOI Creative Commons
Heling Chu, Chuyi Huang, Fang Xie

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100076 - 100076

Published: Jan. 1, 2025

The identification of the modifiable lifestyle factors including dietary habits in older adults preclinical Alzheimer's disease (AD) and early effective interventions are great importance. We studied whether consumption fresh vegetables fruits was different between cognitively unimpaired (CU) impaired (CI) population mainly investigated associations vegetable fruit PET plasma AD biomarkers CU with higher β-amyloid (Aβ) burden. Older age 50-85 years were enrolled for a cross-sectional longitudinal study. groups depended on participants or CI. Partial whose remained unchanged followed up. data collected using validated self-reported questionnaire. various positive 18F-florbetapir scan (Aβ-PET), part whom also underwent tests 18F-MK6240 (tau-PET). Correlation multiple linear regression analyses used to investigate biomarkers. A total 1433 enrolled, which accounted 49.4 %. Most intake CI participants. 177 Aβ-PET selected following Multiple analysis showed (>200 g/d), dark (>100 g/d, ≥2d/week), berries g/d) grapes more less had Aβ40, t-Tau, p-Tau-181 neurofilament light chain as well amyloid Tau associated change cognitive function after an approximately two-year follow-up. Especially, intakes correlated both lower Aβ burden inversely decline Our indicates that vegetables, fruits, is changes Higher may be helpful reducing risk development.

Language: Английский

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