Unveiling the Therapeutic Potential of Banxia Xiexin Decoction in Alzheimer’s Disease: Insights From Network Pharmacology and Experimental Validation DOI Creative Commons
Gaofeng Qin, Rui Song, Jingyi Sun

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 2133 - 2155

Published: March 1, 2025

Alzheimer's disease (AD) is associated with various pathological states for which there no effective treatment. First documented in the Eastern Han Dynasty's medical classic, "Treatise on Febrile and Miscellaneous Diseases" (200-210 Anno Domini), Banxia Xiexin Decoction (BXD) stands as a quintessential approach to treating spleen ailments. Recent studies have shown BXD's effectiveness mitigating memory impairment AD. Yet, precise mechanisms underlying action against AD require further exploration. To explore important components of BXD exerting anti-AD effects molecular using network pharmacology, metabolomics analysis, vitro vivo validation strategies. Initially, candidates application therapy were identified through extensive database searches, followed by an analysis protein-protein interactions (PPI). elucidate therapeutic pathways AD, we engaged Gene Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) assessments. Further, delved into primary constituents ultra-high-pressure liquid chromatography coupled Q Exactive mass spectrometry docking techniques. Finally, AD-associated Aβ42-SY5Y cells APPswe/PS1dE9 (APP/PS1) transgenic mice models utilized determine activity or phenotypic assays analysis. Our findings PI3K/Akt signaling central effects. Using models, found be mediated suppression neuroinflammation apoptosis, accompanied activation pathway. observed robust changes metabolite levels plasma BXD-treated APP/PS1 mice. Through systematic data experimental validation, advantages fundamental revealed. These underscore promising prospects compelling potential BXD, targets pathway inflammation, strategy improving

Language: Английский

Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications DOI Creative Commons
Meng Wang, Chao Wang,

Zhao Kaiwei

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Neurological disorders pose significant global public health challenges, with a rising prevalence and complex pathophysiological mechanisms that impose substantial social economic burdens. Traditional Chinese Medicine (TCM), its holistic approach multi-target effects, has gained increasing attention in the treatment of neurological diseases. This review explores bioactive compounds derived from herbal plants, focusing on their action, underlying pathways, potential applications functional food development. The highlights neuroprotective properties flavonoids, alkaloids, polysaccharides, polyphenols found key TCM herbs such as Scutellaria baicalensis , Salvia miltiorrhiza Ligusticum chuanxiong Gastrodia elata . These have demonstrated anti-inflammatory, antioxidant, neurogenic making them promising candidates for prevention conditions, including Alzheimer’s disease (AD), Parkinson’s (PD), depression. Furthermore, synergistic effects formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially combating neurodegenerative also discusses challenges future directions integrating these into foods dietary supplements, aiming to improve enhance clinical outcomes. Ultimately, this work aims provide valuable insights TCM-based interventions promoting well-being addressing burden disorders.

Language: Английский

Citations

3
Elucidating the anticancer potential of dendrobine in renal cell carcinoma treatment DOI
Xing Jia, Zixuan Chen, Xingyu Chen

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Beneficial Effects of Danggui-Shaoyao-San Against Metabolic Dysfunction Induced by a High-Fat Diet: A Multi-Omic Analysis DOI
Ya-Ru Zhao, Yiming Bi, Wei Zhang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Unveiling the Therapeutic Potential of Banxia Xiexin Decoction in Alzheimer’s Disease: Insights From Network Pharmacology and Experimental Validation DOI Creative Commons
Gaofeng Qin, Rui Song, Jingyi Sun

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 2133 - 2155

Published: March 1, 2025

Alzheimer's disease (AD) is associated with various pathological states for which there no effective treatment. First documented in the Eastern Han Dynasty's medical classic, "Treatise on Febrile and Miscellaneous Diseases" (200-210 Anno Domini), Banxia Xiexin Decoction (BXD) stands as a quintessential approach to treating spleen ailments. Recent studies have shown BXD's effectiveness mitigating memory impairment AD. Yet, precise mechanisms underlying action against AD require further exploration. To explore important components of BXD exerting anti-AD effects molecular using network pharmacology, metabolomics analysis, vitro vivo validation strategies. Initially, candidates application therapy were identified through extensive database searches, followed by an analysis protein-protein interactions (PPI). elucidate therapeutic pathways AD, we engaged Gene Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) assessments. Further, delved into primary constituents ultra-high-pressure liquid chromatography coupled Q Exactive mass spectrometry docking techniques. Finally, AD-associated Aβ42-SY5Y cells APPswe/PS1dE9 (APP/PS1) transgenic mice models utilized determine activity or phenotypic assays analysis. Our findings PI3K/Akt signaling central effects. Using models, found be mediated suppression neuroinflammation apoptosis, accompanied activation pathway. observed robust changes metabolite levels plasma BXD-treated APP/PS1 mice. Through systematic data experimental validation, advantages fundamental revealed. These underscore promising prospects compelling potential BXD, targets pathway inflammation, strategy improving

Language: Английский

Citations

0