Seminars in Immunology, Journal Year: 2025, Volume and Issue: 78, P. 101950 - 101950

Published: April 4, 2025

The hallmarks of cancer are a set traits that normal cells acquire during their transformation into malignancy. Among the biological processes influencing these hallmarks, innate immune complement system plays critical role. It can operate canonically-in blood and tissues-via phagocytosis, inflammation, complement-dependent cytotoxicity, similar to its roles against invading pathogens. Additionally, it functions non-canonically by modulating behavior within tumor microenvironment intracellular landscape which regulates cell fate. These mechanisms contribute complex context-dependent in both growth antitumor immunity, shaped characteristics dynamic microenvironment. This review analyses multifaceted interplay between proteins positioning this as target therapy.

Language: Английский