Comparison of inflammatory biomarker levels in neurodegenerative proteinopathies: a case-control study DOI Creative Commons
Sarah E. Cook, Kateřina Menšíková, Dorota Koníčková

et al.

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract While diagnostic criteria have been established and validated for most neurodegenerative diseases, the considerable overlap between individual nosological entities remains a significant challenge. Increasing evidence suggests that neurodegeneration is often initiated by inflammation within central nervous system. The identification of could serve as first signal pathophysiological process. As such, biological markers (“biomarkers”) neuroinflammation are critically important. This study aimed to assess presence levels inflammatory biomarkers in three diseases: Lewy body diseases (LBD), multiple system atrophy (MSA), 4-repeat tauopathies (4RT). A total 83 LBD, 24 MSA, 31 4RT patients were included, with control subjects comparison. Six immune-related proteins analysed cerebrospinal fluid (CSF) blood serum (serum): C3 complement, C4 haptoglobin, transferrin, orosomucoid, β2 microglobulin (β2M). ANCOVA statistical analysis revealed significantly lower several LBD (CSF: orosomucoid; Serum: β2M) MSA orosomucoid) compared controls. Significant differences also observed synucleinopathy patient groups (LBD MSA) complement. Additionally, CSF/serum quotients transferrin complement (LBD) disease relative These findings suggest processes may play role pathophysiology proteinopathies, warranting further research confirm these associations. potential would then represent promising step forward field.

Language: Английский

Comparison of inflammatory biomarker levels in neurodegenerative proteinopathies: a case-control study DOI Creative Commons
Sarah E. Cook, Kateřina Menšíková, Dorota Koníčková

et al.

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract While diagnostic criteria have been established and validated for most neurodegenerative diseases, the considerable overlap between individual nosological entities remains a significant challenge. Increasing evidence suggests that neurodegeneration is often initiated by inflammation within central nervous system. The identification of could serve as first signal pathophysiological process. As such, biological markers (“biomarkers”) neuroinflammation are critically important. This study aimed to assess presence levels inflammatory biomarkers in three diseases: Lewy body diseases (LBD), multiple system atrophy (MSA), 4-repeat tauopathies (4RT). A total 83 LBD, 24 MSA, 31 4RT patients were included, with control subjects comparison. Six immune-related proteins analysed cerebrospinal fluid (CSF) blood serum (serum): C3 complement, C4 haptoglobin, transferrin, orosomucoid, β2 microglobulin (β2M). ANCOVA statistical analysis revealed significantly lower several LBD (CSF: orosomucoid; Serum: β2M) MSA orosomucoid) compared controls. Significant differences also observed synucleinopathy patient groups (LBD MSA) complement. Additionally, CSF/serum quotients transferrin complement (LBD) disease relative These findings suggest processes may play role pathophysiology proteinopathies, warranting further research confirm these associations. potential would then represent promising step forward field.

Language: Английский

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