Cells,
Journal Year:
2022,
Volume and Issue:
11(3), P. 529 - 529
Published: Feb. 3, 2022
The
development
of
induced
pluripotent
stem
cells
has
brought
unlimited
possibilities
to
the
field
regenerative
medicine.
This
could
be
ideal
for
treating
osteoarthritis
and
other
skeletal
diseases,
because
current
procedures
tend
short-term
solutions.
usage
in
cell-based
regeneration
cartilage
damages
replace
or
improve
on
techniques.
patient’s
specific
non-invasive
collection
tissue
reprogramming
purposes
also
create
a
platform
drug
screening
disease
modelling
an
overview
distinct
abnormalities.
In
this
review,
we
seek
summarise
latest
achievements
chondrogenic
differentiation
modelling.
Expert Opinion on Biological Therapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
The
human
endometrium
is
a
highly
regenerative
tissue
that
contains
mesenchymal
stem/stromal
cells
(MSCs).
These
MSCs
are
sourced
via
office-based
biopsies
and
menstrual
fluid
providing
less
invasive
readily
available
option
for
cell-based
therapies.
This
review
provides
an
update
on
endometrial-derived
as
treatment
gynecological
diseases.
narrative
covers
the
characterization
therapeutic
mechanisms
of
biopsy-derived
(eMSCs)
fluid-derived
stromal
(MenSCs),
highlighting
similarities
differences.
It
also
studies
their
application
in
preclinical
animal
models,
clinical
trials
potential
therapies
eMSCs
MenSCs
from
homologous
source
have
to
promote
activity
Both
demonstrate
benefits
through
paracrine
regeneration,
immunomodulation,
angiogenesis
mitigating
fibrosis.
Further
research
essential
establish
standardized
isolation
protocols,
particularly
heterogeneous
MenSCs,
fully
understand
action.
Implementing
SUSD2
magnetic
bead
sorting
purifying
endometrial
tissues
crucial
use
future
Optimization
production,
storage
delivery
methods
will
maximize
effectiveness.
Stem Cell Research & Therapy,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Aug. 3, 2021
Abstract
Menstrual
blood-derived
mesenchymal
stem
cells
(MenSCs)
have
great
potential
in
regenerative
medicine.
MenSC
has
received
increasing
attention
owing
to
its
impressive
therapeutic
effects
both
preclinical
and
clinical
trials.
However,
the
study
of
MenSC-derived
small
extracellular
vesicles
(EVs)
is
still
initial
stages,
contrast
some
common
MSC
sources
(e.g.,
bone
marrow,
umbilical
cord,
adipose
tissue).
We
describe
basic
characteristics
biological
functions
EVs.
also
demonstrate
EVs
fulminant
hepatic
failure,
myocardial
infarction,
pulmonary
fibrosis,
prostate
cancer,
cutaneous
wound,
type-1
diabetes
mellitus,
aged
fertility,
diseases.
Subsequently,
novel
hotspots
with
respect
EV-based
therapy
are
proposed
overcome
current
challenges.
While
complexities
regarding
continue
be
unraveled,
advances
rapidly
emerging
science
treatment
for
treating
a
series
diseases
as
strategy
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2021,
Volume and Issue:
1876(1), P. 188582 - 188582
Published: June 16, 2021
Mesenchymal
stem
cells
(MSCs)
are
among
the
most
investigated
and
applied
somatic
in
experimental
therapies
for
regeneration
of
damaged
tissues.
Moreover,
as
it
was
recently
postulated,
MSCs
may
demonstrate
anti-tumor
properties.
Glioblastoma
(GBM)
is
a
grade
IV
central
nervous
system
tumor
with
no
available
effective
therapy
an
inevitably
fatal
prognosis.
Experimental
studies
utilizing
GBM
treatment
resulted
numerous
controversies.
Native
were
shown
to
exert
anti-GBM
activity
by
controlling
angiogenesis,
regulating
cell
cycle,
inducing
apoptosis.
They
also
used
sensitizing
factors
vehicles
delivering
various
anti-cancer
compounds.
On
other
hand,
some
experiments
revealed
significant
risks
related
MSC-based
GBM,
such
enhancement
proliferation,
invasion,
aggressiveness.
The
following
review
elaborates
on
all
mentioned
contradictory
data
provides
realistic,
current
clinical
perspective
MSCs'
potential
treatment.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(14), P. 7647 - 7647
Published: July 17, 2021
Hemophilia
is
a
monogenic
mutational
disease
affecting
coagulation
factor
VIII
or
IX
genes.
The
palliative
treatment
of
choice
based
on
the
use
safe
and
effective
recombinant
clotting
factors.
Advanced
therapies
will
be
curative,
ensuring
stable
durable
concentrations
defective
circulating
factor.
Results
have
so
far
been
encouraging
in
terms
levels
times
expression
using
mainly
adeno-associated
vectors.
However,
these
are
associated
with
immunogenicity
hepatotoxicity.
Optimizing
vector
serotypes
transgene
(variants)
boost
efficacy,
thus
increasing
viability
protocols.
It
essential
that
both
physicians
patients
informed
about
potential
benefits
risks
new
therapies,
register
gene
therapy
kept
information
efficacy
long-term
adverse
events
treatments
administered.
In
context
hemophilia,
may
result
(particularly
indirect)
cost
savings
more
equitable
allocation
treatments.
case
hemophilia
A,
further
research
needed
into
how
to
effectively
package
large
vector;
B,
priority
should
optimize
serotype,
reducing
its
hepatotoxicity,
transgene,
boosting
as
minimize
amount
administered
decrease
incidence
without
compromising
protein
expressed.
Cells,
Journal Year:
2022,
Volume and Issue:
11(3), P. 529 - 529
Published: Feb. 3, 2022
The
development
of
induced
pluripotent
stem
cells
has
brought
unlimited
possibilities
to
the
field
regenerative
medicine.
This
could
be
ideal
for
treating
osteoarthritis
and
other
skeletal
diseases,
because
current
procedures
tend
short-term
solutions.
usage
in
cell-based
regeneration
cartilage
damages
replace
or
improve
on
techniques.
patient’s
specific
non-invasive
collection
tissue
reprogramming
purposes
also
create
a
platform
drug
screening
disease
modelling
an
overview
distinct
abnormalities.
In
this
review,
we
seek
summarise
latest
achievements
chondrogenic
differentiation
modelling.
