Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets DOI

Weimeng Ji,

Li Sun,

Deqiang Wang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 983, P. 176996 - 176996

Published: Sept. 12, 2024

Language: Английский

Dual-responsive stem cell microspheres modified with BDNF for enhanced neural repair in diabetic erectile dysfunction DOI
Xiaoying Pan,

Xiaowen Xing,

Zhengguo Ji

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 409 - 420

Published: Jan. 16, 2025

Language: Английский

Citations

0
Engineered 3D mesenchymal stem cell aggregates with multifunctional prowess for bone regeneration: Current status and future prospects DOI Creative Commons
Linxue Zhang, Xiaojing Yuan, Rui Song

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Preventing MSC aging and enhancing immunomodulation: Novel strategies for cell-based therapies DOI

Faranak Elmi,

Fatemeh Soltanmohammadi, Tahura Fayeghi Arjmand

et al.

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 517 - 539

Published: May 5, 2025

Language: Английский

Citations

0
Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids DOI Creative Commons

Yumi Ohori‐Morita,

Amal Ashry,

Kunimichi Niibe

et al.

Stem Cells Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Mesenchymal stromal/stem cells (MSCs) are promising candidates for regenerative medicine owing to their self-renewal properties, multilineage differentiation, immunomodulatory effects, and angiogenic potential. MSC spheroids fabricated by 3D culture have recently shown enhanced therapeutic create a specialized niche with tight cell-cell cell-extracellular matrix interactions, optimizing cellular function mimicking the in vivo environment. Methods cultivation of MSCs can be classified into 2 main forms: static suspension dynamic culture. Numerous studies reported beneficial influence these methods on MSCs, which is displayed increased angiogenic, immunomodulatory, anti-apoptotic stemness spheroids. Particularly, recent highlighted benefits cultures terms faster more compact spheroid formation long-term maintenance properties. However, only few compared behavior formed using cultures, considering significant differences between conditions. This review summarizes discusses biological outcomes literature. In particular, we highlight advantages contemplate its future applications various diseases.

Language: Английский

Citations

3
Therapeutic effect of three-dimensional hanging drop cultured human umbilical cord mesenchymal stem cells on osteoarthritis in rabbits DOI Creative Commons
Qiang Fu, Mei Han, Xiaoyu Dai

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 18, 2024

Language: Английский

Citations

2
Enhancing autologous Equine Therapy: Innovative 3D Culture Method for Muscle-derived Progenitor Cells (mdP-Cells) DOI Creative Commons
Hélène Graide, Jacques Duysens, Thierry Franck

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Abstract Musculoskeletal pathologies pose significant challenges in athletic horses, often leading to loss of function. The limited healing capacity bone, joint, and tendon/ligament injuries, combined with the inefficacy conventional treatments, underscores need for innovative therapeutic strategies such as Mesenchymal Stem/Stroma Cells (MSCs). Conventional cell culture methods typically employ two-dimensional (2D) systems adherent cells using fetal bovine serum. However, three-dimensional (3D) offers a more physiologically relevant milieu, closely resembling native tissue architecture vivo cell-cell interactions. This study introduces novel approach isolating muscle-derived progenitor 3D environment, utilizing an autologous plasma-based gel retrieval solution. cultured this method exhibited immunomodulatory properties on lymphocyte T trilineage differentiation immunophenotyping akin traditional MSCs. simplified technique holds promise generating minimally manipulated products tailored musculoskeletal applications.

Language: Английский

Citations

1
The morphological, behavioral, and transcriptomic life cycle of Anthrobots DOI Open Access

Gizem Gumuskaya,

Nikolai Davey,

Pranjal Srivastava

et al.

Published: Aug. 8, 2024

Fascinating aspects of morphogenetic and behavioral plasticity living material are revealed by novel constructs that self-assemble from genetically wild-type cells. Anthrobots arise cultured adult human airway epithelial cells, developing, becoming self-motile, acquiring neural repair capabilities without exogenous genetic circuits or inorganic scaffolds. Progress in bioengineering regenerative medicine depends on developing a predictive understanding collective cell behavior circumstances. Toward end, here we quantitatively characterize number life cycle properties Anthrobots, including their morphogenesis, maturation, demise. We uncovered self-healing capacity remarkable reduction epigenetic age upon morphogenesis. Transcriptomic analysis assembling into drives massive remodeling gene expression relative to cellular source, several embryonic patterning genes, shift towards more evolutionarily-ancient expression. These data reveal new engineered multicellular configurations, which cells an active construct with its own distinct transcriptome, history.

Language: Английский

Citations

0
Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets DOI

Weimeng Ji,

Li Sun,

Deqiang Wang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 983, P. 176996 - 176996

Published: Sept. 12, 2024

Language: Английский

Citations

0