Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold DOI

Jiyaur Rahaman,

Dhrubojyoti Mukherjee

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Dec. 21, 2024

The occurrence of oral bone tissue degeneration and defects by osteoporosis, tooth extraction, obesity, trauma, periodontitis are major challenges for clinicians. Traditional regeneration methods often come with limitations such as donor site morbidity, limitation special shape, inflammation, resorption the implanted bone. treatment oriented biomimetic materials has achieved significant attention recently. In engineering arena, insulin gained considerable among all known biomaterials osteogenesis angiogenesis. It also exhibits osteogenic angiogenic properties interacting receptors on osteoblasts. Insulin influences remodelling both directly indirectly. acts through PI3K/Akt MAPK signalling pathways indirectly modulating RANK/RANKL/OPG pathway, which helps reduce resorption. current review reports role in cavity form scaffolds nanomaterials. Different delivery systems, utilising nanomaterials functionalised polymeric have been explored regeneration. put forward a theoretical basis future research composite

Language: Английский

Revealing the molecular mechanism of Buzhong Yiqi Decoction for tendon bone healing on the basis of network pharmacology, molecular docking and experimental validation DOI
Shibo Xu, Yihang Yu,

qizhong xie

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119726 - 119726

Published: April 1, 2025

Language: Английский

Citations

0
SNPs in GPCR Genes and Impaired Osteogenic Potency in Osteoporotic Patient Lines-Based Study DOI Open Access
Julia V. Sopova, Olga Krasnova,

G. I. Vasilieva

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13594 - 13594

Published: Dec. 19, 2024

G-protein-coupled receptors (GPCRs) have emerged as critical regulators of bone development and remodeling. In this study, we aimed to identify specific GPCR mutations in osteoporotic patients via next-generation sequencing (NGS). We performed NGS six genomic DNA samples taken from two healthy donors. Next, searched for single-nucleotide polymorphisms (SNPs) genes that are associated with osteoporosis. For three one donor, biopsies were used generate patient-specific mesenchymal stem cell (MSC) lines, their ability undergo osteodifferentiation was analyzed. found MSCs derived a different response osteoinductive factors impaired osteogenic differentiation using qPCR histochemical staining assays. The analysis revealed combinations SNPs these patients, where ADRB2 (rs1042713), GIPR (rs1800437), CNR2 (rs2501431, rs3003336), WLS (rs3762371) capacity. By integrating data functional assessments linked formation, providing foundation developing personalized therapeutic strategies. SNP is recognized proactive approach osteoporosis management, enabling earlier interventions targeted preventive measures individuals at risk. Furthermore, contributes the robust, holistic risk prediction models enhance accuracy across population. This integration genetic into public health strategies facilitates healthcare initiatives. could guide treatment decisions tailored patient’s profile provide

Language: Английский

Citations

1
Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold DOI

Jiyaur Rahaman,

Dhrubojyoti Mukherjee

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Dec. 21, 2024

The occurrence of oral bone tissue degeneration and defects by osteoporosis, tooth extraction, obesity, trauma, periodontitis are major challenges for clinicians. Traditional regeneration methods often come with limitations such as donor site morbidity, limitation special shape, inflammation, resorption the implanted bone. treatment oriented biomimetic materials has achieved significant attention recently. In engineering arena, insulin gained considerable among all known biomaterials osteogenesis angiogenesis. It also exhibits osteogenic angiogenic properties interacting receptors on osteoblasts. Insulin influences remodelling both directly indirectly. acts through PI3K/Akt MAPK signalling pathways indirectly modulating RANK/RANKL/OPG pathway, which helps reduce resorption. current review reports role in cavity form scaffolds nanomaterials. Different delivery systems, utilising nanomaterials functionalised polymeric have been explored regeneration. put forward a theoretical basis future research composite

Language: Английский

Citations

1