Melatonin regulation and the function of the periodontal ligament: Future perspective and challenges
World Journal of Stem Cells,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 17, 2025
The
present
article
reviews
the
emerging
role
of
melatonin
(MT)
and
Hippo-Yes-associated
protein
signaling
pathway
in
periodontal
regeneration,
highlighting
their
potential
to
delay
aging
process
ligament
stem
cells
(PDLSCs).
Oxidative
stress
cellular
senescence
are
major
obstacles
regenerative
therapies,
especially
an
population.
MT,
a
potent
antioxidant,
restores
morphology,
proliferation,
osteogenic
differentiation
PDLSCs
under
oxidative
conditions.
Recent
research
highlights
how
MT
enhances
PDLSC
stemness
by
upregulating
Yes-associated
expression,
offering
promising
therapeutic
strategy
antagonize
tissue
degeneration.
In
addition,
discusses
growing
interest
probiotics
as
complementary
approach
improve
oral
microbiota
support
regeneration.
integration
with
traditional
novel
approaches
may
pave
way
for
innovative
preventive
or
active
treatments
periodontology,
aimed
at
reducing
stress.
Future
needs
focus
on
translating
these
findings
into
clinical
applications
promoting
deeper
understanding
regeneration
aging.
Language: Английский
Inflammatory Modulation of Toll-like Receptors in Periodontal Ligament Stem Cells: Implications for Periodontal Therapy
Cells,
Journal Year:
2025,
Volume and Issue:
14(6), P. 432 - 432
Published: March 13, 2025
Toll-like
receptors
(TLRs)
play
a
crucial
role
in
the
innate
immune
response,
mediating
cellular
interactions
with
microenvironment
and
influencing
periodontal
disease
progression.
This
vitro
study
aimed
to
comprehensively
characterize
TLR
expression
profile
of
ligament
mesenchymal
stem/progenitor
cells
(PDLSCs)
investigate
its
modulation
by
inflammatory
stimuli
associated
disease.
PDLSCs
(n
=
6)
were
isolated,
selected
using
anti-STRO-1
antibodies,
cultured
evaluate
their
colony-forming
abilities
characteristics.
Baseline
inflammation-induced
expressions
evaluated
RT-PCR
protein
analyses
following
cytokine-mediated
stimulation.
exhibited
expected
stem
cell
characteristics
expressed
multiple
TLRs
under
both
conditions.
Notably,
stimulation
significantly
upregulated
TLR1
TLR2
while
downregulating
TLR10
(p
<
0.05).
These
findings
provide
comprehensive
characterization
demonstrate
how
inflammation
modulates
profile.
The
observed
shifts
may
influence
PDLSC
responses
microbial
pathogens
impact
immunomodulatory
regenerative
properties
tissues.
Understanding
these
could
contribute
developing
targeted
strategies
for
improving
PDLSC-based
therapies
Language: Английский