The Role of Tissue Engineering in Orthodontic and Orthognathic Treatment: A Narrative Review DOI Creative Commons
Rosana Farjaminejad, Samira Farjaminejad,

Melika Hasani

et al.

Oral, Journal Year: 2025, Volume and Issue: 5(1), P. 21 - 21

Published: March 20, 2025

Background: Orthodontics and orthognathic surgery present challenges such as extended treatment durations, patient discomfort, complications like root resorption. Recent advancements in tissue engineering nanotechnology offer promising solutions by improving bone regeneration, periodontal repair, biomaterial integration. Objectives: This review explores the integration of scaffold-based orthodontics, focusing on their roles accelerating reducing times, minimizing adverse effects to enhance predictability success orthodontic interventions. Methods: Relevant literature was selected from PubMed, Scopus, Web Science, studies related scaffold technology, biomaterials, orthodontics. Keywords included “tissue engineering”, “orthodontics”, “biomaterials”, “scaffolds”, “nanotechnology”, “bone regeneration”. Priority given peer-reviewed original studies, systematic reviews, meta-analyses addressing innovative approaches clinical outcomes. Results: Findings indicate that scaffolds regeneration while nanoparticles improve drug delivery efficiency. These contribute faster, more predictable treatments with reduced complications. However, high costs, regulatory hurdles, need for long-term validation remain barriers widespread adoption. Conclusions: Tissue minimally invasive, biologically driven treatment. While significant progress has been made, further cost-effective strategies, approvals are needed integrate these innovations into routine practice.

Language: Английский

Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications DOI Creative Commons
Qing Miao, Shaoqing Li, Wei Lyu

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 457 - 469

Published: Jan. 1, 2025

Exosomes, small extracellular vesicles secreted by various cells, play crucial roles in the pathogenesis and treatment of oral diseases. Recent studies have highlighted their involvement orthodontics, periodontitis, squamous cell carcinoma (OSCC), hand, foot, mouth disease (HFMD). Exosomes a positive effect on inflammatory environment cavity, remodeling regeneration tissues, offer promising therapeutic options for bone periodontal tissue restoration. In OSCC tumor-derived exosomes promote cancer progression through proliferation, migration, invasion, angiogenesis, serve as potential biomarkers early diagnosis prognosis. Additionally, engineered constructed specifically based exosome properties hold great promise targeted drug delivery regenerative therapies such orthodontics healing. With continued research, improving diseases, advancing personalized therapies.

Language: Английский

Citations

0
The Role of Tissue Engineering in Orthodontic and Orthognathic Treatment: A Narrative Review DOI Creative Commons
Rosana Farjaminejad, Samira Farjaminejad,

Melika Hasani

et al.

Oral, Journal Year: 2025, Volume and Issue: 5(1), P. 21 - 21

Published: March 20, 2025

Background: Orthodontics and orthognathic surgery present challenges such as extended treatment durations, patient discomfort, complications like root resorption. Recent advancements in tissue engineering nanotechnology offer promising solutions by improving bone regeneration, periodontal repair, biomaterial integration. Objectives: This review explores the integration of scaffold-based orthodontics, focusing on their roles accelerating reducing times, minimizing adverse effects to enhance predictability success orthodontic interventions. Methods: Relevant literature was selected from PubMed, Scopus, Web Science, studies related scaffold technology, biomaterials, orthodontics. Keywords included “tissue engineering”, “orthodontics”, “biomaterials”, “scaffolds”, “nanotechnology”, “bone regeneration”. Priority given peer-reviewed original studies, systematic reviews, meta-analyses addressing innovative approaches clinical outcomes. Results: Findings indicate that scaffolds regeneration while nanoparticles improve drug delivery efficiency. These contribute faster, more predictable treatments with reduced complications. However, high costs, regulatory hurdles, need for long-term validation remain barriers widespread adoption. Conclusions: Tissue minimally invasive, biologically driven treatment. While significant progress has been made, further cost-effective strategies, approvals are needed integrate these innovations into routine practice.

Language: Английский

Citations

0