Molecular Immunology, Journal Year: 2025, Volume and Issue: 183, P. 18 - 32
Published: May 2, 2025
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 13, 2025
This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.
Language: Английский
Citations
12
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 268, P. 155873 - 155873
Published: Feb. 27, 2025
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 940 - 940
Published: March 10, 2025
Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125483 - 125483
Published: March 1, 2025
Language: Английский
Citations
0
Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)
Published: March 20, 2025
Abstract Cancer ranks among the most lethal diseases worldwide. Tissue biopsy is currently primary method for diagnosis and biological analysis of various solid tumors. However, this has some disadvantages related to insufficient tissue specimen collection intratumoral heterogeneity. Liquid a noninvasive approach identifying cancer-related biomarkers in peripheral blood, which allows repetitive sampling across multiple time points. In field liquid biopsy, representative include circulating tumor cells (CTCs), DNA (ctDNA), exosomes. Many studies have evaluated prognostic predictive roles CTCs ctDNA Although these limitations, results appear consistently demonstrate correlations high CTC counts mutations with lower survival rates cancer patients. Similarly, reduction throughout therapy may be potential indicator treatment response advanced Moreover, biochemical characteristics can provide information about biology as well resistance mechanisms against targeted therapy. This review discusses current clinical applications patients, emphasizing its possible utility outcome prediction decision-making.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 22, 2025
Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.
Language: Английский
Citations
0
Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(4)
Published: April 1, 2025
Abstract Urological tumours are a type of neoplasms that significantly jeopardise human life and wellbeing. Cancer‐associated fibroblasts (CAFs), serving as the primary component stromal cellular milieu, form diverse cohort exerts substantial influence on tumourigenesis tumour progression. In this review, we summarised literatures regarding functions CAFs in urinary microenvironment (TME). We primarily examined multifaceted activities TME urological system tumours, including inhibiting immunity, remodelling extracellular matrix, promoting growth, metastasis, drug resistance their clinical applications. also discussed potential future directions for leveraging artificial intelligence research. Key points The interaction with various cell secretory factors tumors. application diagnosis, treatment prognosis
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 15, 2025
Melanoma, being one of the most dangerous forms skin cancer, is characterized by its aggressive and metastatic nature, with potential to develop resistance various treatments. This makes disease challenging treat, emphasizing need for new treatment strategies. Within tumor microenvironment (TME), melanoma cells exploit metabolic shifts, particularly glycolysis, create an immunosuppressive TME that prevents dendritic (DCs) from functioning properly. Essential alterations such as lactate lipid accumulation, lack tryptophan disrupt DC maturation, antigen presentation, T cell activation. In recent years, immunotherapy has increasingly focused on reprogramming metabolism DCs. review paper aims provide insights into suppression melanoma-associated DCs, allowing design therapeutic strategies based interventions promote or restore function. contribution reviews DCs a approach immunotherapy.
Language: Английский
Citations
0
Molecular Immunology, Journal Year: 2025, Volume and Issue: 183, P. 18 - 32
Published: May 2, 2025
Language: Английский
Citations
0