The Hippo pathway in bone and cartilage: implications for development and disease DOI Creative Commons
Chuan Shao, Hao Chen, Tingting Liu

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19334 - e19334

Published: April 22, 2025

Bone is the main structure of human body; it mainly plays a supporting role and participates in metabolic processes. The Hippo signaling pathway composed series protein kinases, including mammalian STE20-like kinase MST1/2 large tumor suppressor LATS1/2, which are widely involved pathophysiological processes, cell proliferation, differentiation, apoptosis death, especially those related to biomechanical transduction vivo . However, regulating skeletal system development evolution bone-related diseases remains poorly understood. can intervene regulate physiological activities cells such as osteoclasts chondrocytes through its own or other pathways, Wnt pathway, Notch receptor activator nuclear factor-κB ligand (RANKL), thereby affecting occurrence bone diseases. This article discusses disease provide new insights into treatment by targeting pathway.

Language: Английский

Reparative Effects of VCAM-1 High-Performance MSC-derived Exosomes on Aged Diabetic Cardiomyocyte Injury: A Focus on Ferroptosis Suppression DOI

Xiaoyang Yin,

Yimeng Wei,

Yü Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Background: The cardiac dysfunction in elderly diabetes, resulting from the superimposition of age-related myocardial senescence and diabetes-induced injury, is difficult to intervene lacks effective therapeutic strategies. Recent studies have revealed that ferroptosis may be a key mechanism underlying cardiomyocyte injury diabetic cardiomyopathy. Mesenchymal stem cells (MSCs) their secreted exosomes shown potential promoting repair, restoring function, improving insulin sensitivity, mitigating diabetes-related complications. MSCs or promote repair cardiomyocytes recovery while also sensitivity alleviating damage However, mechanisms actions -derived exosomes, as well relationship with ferroptosis, remain unclear. Methods: model high-glucose-damaged senescent was established by continuously culturing H9c2 primary rat high-glucose condition, combined H₂O₂ induction. And, animal cardiomyopathy aged rats high-fat diet feeding streptozotocin (STZ) administration, followed keeping on diet. cell were administrated VCAM-1⁺ derived subsequently, phenotypes, transcriptome sequencing, expression genes related assessed. Results: In cardiomyocytes, tissues cardiomyopathy, mitochondrial damage, iron-ion accumulation, reactive oxygen species (ROS) significantly elevated, accompanied weakened function pronounced features ferroptosis. After intervention degree senescence, alleviated, leading improved function. tissue, Ras/Raf/MEK/ERK/c-FOS pathway activated, MSC-derived treatment inhibited this activation. Notably, reparative effect MSCs-derived superior conventional exosomes. Conclusion: Exosomes VCAM-1+ attenuate via suppression pathway, thereby ameliorating ageing-caused

Language: Английский

Citations

0
The Hippo pathway in bone and cartilage: implications for development and disease DOI Creative Commons
Chuan Shao, Hao Chen, Tingting Liu

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19334 - e19334

Published: April 22, 2025

Bone is the main structure of human body; it mainly plays a supporting role and participates in metabolic processes. The Hippo signaling pathway composed series protein kinases, including mammalian STE20-like kinase MST1/2 large tumor suppressor LATS1/2, which are widely involved pathophysiological processes, cell proliferation, differentiation, apoptosis death, especially those related to biomechanical transduction vivo . However, regulating skeletal system development evolution bone-related diseases remains poorly understood. can intervene regulate physiological activities cells such as osteoclasts chondrocytes through its own or other pathways, Wnt pathway, Notch receptor activator nuclear factor-κB ligand (RANKL), thereby affecting occurrence bone diseases. This article discusses disease provide new insights into treatment by targeting pathway.

Language: Английский

Citations

0