Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 14, 2025
Heat shock protein 70 (HSP70) is a highly conserved molecular chaperone that plays core role in assisting folding and maintaining cellular homeostasis. In recent years, studies have revealed HSP70 has dual functions immune regulation: on the one hand, it enhances responses by activating non-specific immunity (such as Toll-like receptor 2/4 (TLR2/4) signaling pathways) specific cross-presentation of antigens, T helper 1 (Th1)/T 17 (Th17) differentiation); other inhibits excessive reactions inducing differentiation regulatory cells (Treg) promoting secretion anti-inflammatory factors [such interleukin-10 (IL-10)]. cancer, duality also very prominent: can drive tumor progression through pathways such inhibiting apoptosis, angiogenesis, metastasis, inhibit growth immunogenic cell death (ICD), enhancing antigen presentation, natural killer (NK) activity. This review aims to systematically analyze HSP70, focusing its mechanisms “double-edged sword” nature immunotherapy innovative targeted strategies, well providing theoretical basis research directions for precision medicine treatment strategies related diseases.
Language: Английский