Unraveling exosome-mediated cancer therapy resistance: pathways and therapeutic challenges DOI Creative Commons

Sandip Sonwane,

Umesh Telrandhe, Nikhita Chambhare

et al.

Journal of the Egyptian National Cancer Institute, Journal Year: 2025, Volume and Issue: 37(1)

Published: May 1, 2025

Extracellular vesicles (EVs) have emerged as key cell-to-cell communication mediators and play significant roles in both physiological pathological processes. In EVs, exosomes represent a distinct subpopulation of EVs that been found to be involved cancer initiation therapeutic resistance. Exosomes transfer diverse spectrum molecular cargos effects on the tumor microenvironment (TME), thereby enabling initiation, metastasis, recently interest therapy due their role important treatment The exosomal content-proteins, miRNAs, lncRNAs-allows perform functions including drug efflux detoxification, cell death pathway modulation, induction epithelial-to-mesenchymal transition (EMT), suppression immune system. addition facilitating stromal interactions, cause extracellular matrix remodeling induce heterogeneity, making it more difficult respond therapy. This review covers intricate resistance with regard biogenesis, content, functional impact TME. Along this, we also discuss new strategies overcome exosome-mediated utilizing exosome inhibitors, designed therapy, combination conventional therapies. While hold promise prediction diagnosis through biomarker function, heterogeneous origins cryptic make target interventions. emphasizes research pathways is urgently required develop can improve outcomes.

Language: Английский

Unraveling exosome-mediated cancer therapy resistance: pathways and therapeutic challenges DOI Creative Commons

Sandip Sonwane,

Umesh Telrandhe, Nikhita Chambhare

et al.

Journal of the Egyptian National Cancer Institute, Journal Year: 2025, Volume and Issue: 37(1)

Published: May 1, 2025

Extracellular vesicles (EVs) have emerged as key cell-to-cell communication mediators and play significant roles in both physiological pathological processes. In EVs, exosomes represent a distinct subpopulation of EVs that been found to be involved cancer initiation therapeutic resistance. Exosomes transfer diverse spectrum molecular cargos effects on the tumor microenvironment (TME), thereby enabling initiation, metastasis, recently interest therapy due their role important treatment The exosomal content-proteins, miRNAs, lncRNAs-allows perform functions including drug efflux detoxification, cell death pathway modulation, induction epithelial-to-mesenchymal transition (EMT), suppression immune system. addition facilitating stromal interactions, cause extracellular matrix remodeling induce heterogeneity, making it more difficult respond therapy. This review covers intricate resistance with regard biogenesis, content, functional impact TME. Along this, we also discuss new strategies overcome exosome-mediated utilizing exosome inhibitors, designed therapy, combination conventional therapies. While hold promise prediction diagnosis through biomarker function, heterogeneous origins cryptic make target interventions. emphasizes research pathways is urgently required develop can improve outcomes.

Language: Английский

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