Social housing effects of Intermittent Access of Methamphetamine Self-administration and social behavior

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Social support is a potentially protective factor against substance use disorders (SUDs). Previous studies in animal models for SUDs have shown that when females are pair housed, they lower motivation cocaine and methamphetamine (METH), than who single housed. In males, however, social housing has not had the same beneficial effect. This study investigates effects of on METH self-administration or males both cagemates self-administering METH. The also investigated how quality those relationships changed after self-administration. results showed singly housed self-administered more socially females, while conditions at rate. behavior data given saline spend time apart, however together, suggesting their may play role attenuation Males' remained unchanged Males was affected by whether were dominant partner, females' dominance. this provides some benefits to Further, type relationship between cage mates affects males' explain why with sex mate males. Background: rats drugs such as individual cocaine.Purpose: aim investigate if would attenuate self-administration, dominance played rate extent which related self-administration.Methods: Male female individually pairs from around day 42, then animals underwent (0.3 mg/kg/inf) an intermittent access (IntA) schedule reinforcement. Both evaluated prior throughout period METH.Results: More one IntA high rates compared differences attenuated first session, but still greater overall. apart together. suggested contribute largely continued exhibit behaviors. Furthermore, dominance, exhibiting responding non-dominant males.Conclusions: Pair less females.Pair male did housing.Females spent together.Males' status.

Language: Английский

Neonatal estradiol and early adversity interact to modify basolateral amygdala morphology and adult behavior in female rats

Journal of Neuroendocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Being raised under adverse conditions during infancy and childhood represents a significant risk factor for developing later psychopathologies dysfunctions in emotional, affective, cognitive abilities. Depending on the type, timing, duration of early adversity, different consequences emerge across sexes both human animal models, although our understanding underlying interactions between sex life stress (ELS) is still incomplete. In this study, we used limited bedding (LB) paradigm, well‐described model ELS rat pups first 10 days life, tested whether masculinization female brain by neonatal injections estradiol benzoate (EB) would recapitulate ELS‐induced vulnerability phenotype males morphology basolateral amygdala (BLA) principal neurons pre‐adolescent adult behavior. Our results show that LB‐induced morphological changes BLA weaning rats were eliminated EB treatment independently estrogen receptor (ERα) expression region. synergized with LB to enhance play behavior females levels far greater than those observed control males. offspring, reduced time spent center tended increase social contact compared normal females, but only conditions. findings indicate modifies specific, not all aspects are altered ELS.

Language: Английский