Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 229 - 229

Published: Jan. 20, 2025

COVID-19 has caused widespread morbidity and mortality, with its effects extending to multiple organ systems. Despite known risk factors for severe disease, including advanced age underlying comorbidities, patient outcomes can vary significantly. This variability complicates efforts predict disease progression tailor treatment strategies. While diagnostic therapeutic approaches are still under debate, RNA sequencing (RNAseq) emerged as a promising tool provide deeper insights into the pathophysiology of guide personalized treatment. A comprehensive literature review was conducted using PubMed, Scopus, Web Science, Google Scholar. We employed Medical Subject Headings (MeSH) terms relevant keywords identify studies that explored role RNAseq in diagnostics, prognostics, therapeutics. proven instrumental identifying molecular biomarkers associated severity patients COVID-19. It allows differentiation between asymptomatic symptomatic individuals sheds light on immune response mechanisms contribute progression. In critically ill patients, been crucial key genes may outcomes, guiding decisions, assessing long-term virus. Additionally, helped understanding persistence viral after recovery, offering new management post-acute sequelae, long COVID. significantly improves management, particularly by enhancing accuracy, personalizing treatment, predicting responses. refines stratification, improving holds promise targeted interventions both acute

Language: Английский

Post COVID-19 mucormycosis in critical care settings: A prospective cohort study in a tertiary care center in Egypt

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 17(10), P. 102523 - 102523

Published: Aug. 23, 2024

The emergence of mucormycosis as a life-threatening fungal infection after the coronavirus disease 2019 (COVID-19) is major concern and challenge, but there limited information on risk factors for mortality in patients. We conducted prospective cohort study from May 2021 to April 2022 determine in-hospital outcomes post-COVID-19 during intensive care unit (ICU) stay. sample was collected consecutive sampling using all accessible patients period. Statistical Package Social Sciences (SPSS), version 25 (IBM, Chicago, Illinois, USA) used statistical analysis. Among 150 with mucormycosis, majority had primary sinus (86.0 %), while 11.3 % both ocular infections, 2.7 cutaneous infections. Around 21 (n = 31) deceased staying ICU median (range) 45.0 (10.0-145.0) days. who pneumonia patches computed tomography (CT) (90.3 %) none were discharged (p < 0.001). group higher rates pulmonary embolism (93.5 compared surviving groups (21.8 %). In multivariate Cox regression analysis, death older above 60 years old (hazard ratio (95 %CI): 6.7 (1.73-15.81)), increase among patient history steroid administration 5.70 (1.23-10.91)), facial 8.76 (1.78-25.18)), uncontrolled diabetes 10.76 (1.78, 65.18)), total leukocytic count (TLC>10 ×103 mcL) 10.03 (3.29-30.61)). Identifying high-risk especially diabetic corticosteroid detecting their deterioration quickly crucial reducing rates, these must be considered when developing treatment quarantine strategies.

Language: Английский

Mucormycosis during the COVID-19 pandemicOur takeaways

IP Journal of Otorhinolaryngology and Allied Science, Journal Year: 2024, Volume and Issue: 7(2), P. 31 - 34

Published: Aug. 2, 2024

is a rare, opportunistic fungal infection that affects immune-compromised hosts. When involving the PNS, it can be Rhino-orbital or Rhinocerebral and may rapidly prove fatal. We present retrospective case series analysis of 48 patients from COVID-19 pandemic, our management them, takeaways. Out 48, 12 had previous history oxygen therapy, 32 tested positive for recently,8 ICU admission, most common occupations affected were homemakers housewives. Grade 2 3 rhino-orbital cerebral (ROCM)were commonly found, 28 developed type diabetes before after ROCM 4 in aftermath disease. A high degree suspicion should maintained all with nasal, orbital, neuro complaints without co-morbid conditions.

Language: Английский