Unravelling the role of the skin microbiome in immunodermatological diseases: implications for therapeutic interventions DOI Open Access

Haily Fritts,

Kelly Frasier,

Grace Herrick

et al.

International Journal of Research in Dermatology, Journal Year: 2025, Volume and Issue: 11(2), P. 190 - 198

Published: Feb. 24, 2025

The skin microbiome, comprising diverse microbial communities, is pivotal in maintaining cutaneous homeostasis and modulating immune responses immunodermatological diseases. This review provides an overview of recent research investigating the interplay between microbiome autoimmune, allergic, inflammatory conditions, such as psoriasis, eczema, acne vulgaris. Current evidence suggests that alterations composition, termed dysbiosis, may contribute to disease pathogenesis exacerbate inflammation disorders. Furthermore, microbial-derived metabolites immune-modulating factors produced by commensal bacteria can influence local barrier function. Future directions include evaluating how interacts with host system, identifying biomarkers for diagnosis prognosis, exploring microbiome-targeted therapeutic interventions, probiotics, transplantation, metabolite supplementation. By leveraging insights from research, personalized approaches managing diseases offer novel avenues restoring improving patient outcomes.

Language: Английский

Diverse Colonisation and Disease Associations of the Human Commensal Malassezia: Our Body's Secret Tenant DOI Open Access
Jayaprakash Sasikumar,

Rumaisa Ali Ebrahim,

Shankar Das

et al.

Mycoses, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 1, 2025

ABSTRACT A niche in the context of microorganisms defines specific ecological role or habitat inhabited by microbial species within an ecosystem. For human commensal Malassezia , skin surface is considered its primary niche, where it adapts to environment utilising lipids as main carbon and energy source. However pathogenic characteristics include production allergens, immune modulation excessive lipid utilisation, which result several diseases such pityriasis versicolor, seborrheic dermatitis, folliculitis atopic dermatitis. Recent studies have revealed colonisation internal organs, including lungs, gut, genitourinary tract, eyes, ears breast milk. In these associated with linked respiratory conditions, neurological disorders, gastrointestinal genital infections. The system plays a critical shaping prevalence, factors like, suppressive drugs underlying health conditions influencing susceptibility. Accurate diagnosis ‐related disorders challenging due unique growth requirements, but molecular fingerprinting assays sequencing methods, particularly ITS sequencing, offer precise identification. Treatment involves antifungal drugs, corticosteroids phytocompounds, yet recurrent infections highlight need for more targeted therapeutic strategies addressing 's characteristics. Understanding complex interactions between host organs crucial diagnosis, treatment prevention exploring potentially beneficial roles disease. This review highlights current findings on intricate diverse ecosystem body, underscoring complexity associations emphasising their multifaceted

Language: Английский

Citations

1
From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences DOI

Bharati Naik,

Jayaprakash Sasikumar, Shankar Das

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Language: Английский

Citations

5
Emergence of fungal hybrids – potential threat to humans. DOI
Jayaprakash Sasikumar,

Heena Azhar Shaikh,

Bharati Naik

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107278 - 107278

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cancer-associated fungi: An emerging powerful player in cancer immunotherapy DOI
Tianhang Li, Xiangyu Wu, Xiangyang Li

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189287 - 189287

Published: Feb. 17, 2025

Language: Английский

Citations

0
Enhanced visualization of nuclear staining and cell cycle analysis for the human commensal Malassezia DOI Creative Commons
Jayaprakash Sasikumar, Suparna Laha,

Bharati Naik

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

Language: Английский

Citations

3
A greener side of health care: Revisiting phytomedicine against the human fungal pathogen Malassezia DOI
Jayaprakash Sasikumar,

P. Keerthana,

Bharati Naik

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 179, P. 106243 - 106243

Published: Oct. 9, 2024

Language: Английский

Citations

3
Skin inflammation and lipid disorder induced by topical application of Mal f 1 DOI
Linmei Li,

Hanxi Wu,

Yao Li

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114051 - 114051

Published: Jan. 18, 2025

Language: Английский

Citations

0
Unravelling the role of the skin microbiome in immunodermatological diseases: implications for therapeutic interventions DOI Open Access

Haily Fritts,

Kelly Frasier,

Grace Herrick

et al.

International Journal of Research in Dermatology, Journal Year: 2025, Volume and Issue: 11(2), P. 190 - 198

Published: Feb. 24, 2025

The skin microbiome, comprising diverse microbial communities, is pivotal in maintaining cutaneous homeostasis and modulating immune responses immunodermatological diseases. This review provides an overview of recent research investigating the interplay between microbiome autoimmune, allergic, inflammatory conditions, such as psoriasis, eczema, acne vulgaris. Current evidence suggests that alterations composition, termed dysbiosis, may contribute to disease pathogenesis exacerbate inflammation disorders. Furthermore, microbial-derived metabolites immune-modulating factors produced by commensal bacteria can influence local barrier function. Future directions include evaluating how interacts with host system, identifying biomarkers for diagnosis prognosis, exploring microbiome-targeted therapeutic interventions, probiotics, transplantation, metabolite supplementation. By leveraging insights from research, personalized approaches managing diseases offer novel avenues restoring improving patient outcomes.

Language: Английский

Citations

0