The Molecular Pharmacology of Phloretin: Anti-Inflammatory Mechanisms of Action

Biomedicines, Journal Year: 2023, Volume and Issue: 11(1), P. 143 - 143

Published: Jan. 6, 2023

The isolation of phlorizin from the bark an apple tree in 1835 led to a flurry research on its inhibitory effect glucose transporters intestine and kidney. Using as prototype drug, antidiabetic agents with more selective activity towards transport at kidney have subsequently been developed. In contrast, hydrolysis product body, phloretin, which is also found plant, has weak properties. Phloretin, however, displays range pharmacological effects including antibacterial, anticancer, cellular organ protective properties both vitro vivo. this communication, molecular basis anti-inflammatory mechanisms that attribute scrutinised. These include inhibiting signalling pathways inflammatory mediators' expression support suppressive immune cells overactivation, obesity-induced inflammation, arthritis, endothelial, myocardial, hepatic, renal lung injury, inflammation gut, skin, nervous system, among others.

Language: Английский

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Fecal fermentation and high-fat diet-induced obesity mouse model confirmed exopolysaccharide from Weissella cibaria PFY06 can ameliorate obesity by regulating the gut microbiota

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 318, P. 121122 - 121122

Published: June 15, 2023

Language: Английский

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SIRT1: Harnessing multiple pathways to hinder NAFLD

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107155 - 107155

Published: March 23, 2024

Non-alcoholic fatty liver disease (NAFLD) encompasses hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. It is the primary cause of chronic disorders, with a high prevalence but no approved treatment. Therefore, it indispensable to find trustworthy therapy for NAFLD. Recently, mounting evidence illustrates that Sirtuin 1 (SIRT1) strongly associated SIRT1 activation or overexpression attenuate NAFLD, while deficiency aggravates Besides, an array therapeutic agents, including natural compounds, synthetic traditional Chinese medicine formula, stem cell transplantation, alleviates NALFD via upregulation. Mechanically, NAFLD by reestablishing autophagy, enhancing mitochondrial function, suppressing oxidative stress, coordinating lipid metabolism, as well reducing hepatocyte apoptosis inflammation. In this review, we introduced structure function briefly, summarized effect on its mechanism, along application agonists in treating

Language: Английский

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A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12091 - 12091

Published: Nov. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Language: Английский

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Punicalagin from pomegranate ameliorates TNF-α/IFN-γ-induced inflammatory responses in HaCaT cells via regulation of SIRT1/STAT3 axis and Nrf2/HO-1 signaling pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111665 - 111665

Published: Feb. 16, 2024

Punicalagin (PUN) was isolated from the peel of pomegranate (Punica granatum L.), is a polyphenol with anti-inflammatory, hepatoprotective, and antioxidant activities. However, it remains unclear whether PUN alleviates inflammation anti-inflammatory mechanisms in pro-inflammatory cytokines-induced human keratinocyte HaCaT cells. Here, we investigated that tumor necrosis factor-alpha (TNF-α) interferon-gamma (IFN-γ) mixture-stimulated cells were treated various concentrations PUN, followed by analyzed expression inflammation-related mediators evaluate anti-inflammatory-related pathways. Our results demonstrated ≤ 100 μM did not reduce cell viability, ≥ 3 sufficient to decrease interleukin-6 (IL-6), IL-8, monocyte chemoattractant protein-1 (MCP-1), chemokine ligand 5 (CCL5), CCL17 CCL20 concentrations. We found 10 significantly increased sirtuin 1 (SIRT1) inhibited signal transducer activator transcription (STAT3) phosphorylation, respectively. downregulated proteins cyclooxygenase-2 (COX-2) inducible nitric oxide synthase (iNOS), enhanced nuclear factor erythroid-2-related factor-2 (Nrf2) heme oxygenase-1 (HO-1) expression. Moreover, decreased intercellular adhesion molecule-1 (ICAM-1) inflamed also suppressed inflammatory-related pathways, including mitogen-activated protein kinase (MAPK) factor-kappa B (NF-κB) signaling pathways TNF-α/IFN-γ- stimulated HaCat Collectively, there significant evidence has effective protective defenses against TNF-α/IFN-γ-induced skin enhancing SIRT1 mediate STAT3 Nrf2/HO-1 pathway.

Language: Английский

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Abnormal metabolism in hepatic stellate cells: Pandora's box of MAFLD related hepatocellular carcinoma

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(2), P. 189086 - 189086

Published: Feb. 9, 2024

Language: Английский

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Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice

The Journal of Nutritional Biochemistry, Journal Year: 2021, Volume and Issue: 91, P. 108602 - 108602

Published: Feb. 5, 2021

Language: Английский

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Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD

The Journal of Nutritional Biochemistry, Journal Year: 2022, Volume and Issue: 107, P. 109062 - 109062

Published: May 21, 2022

Language: Английский

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Anti-adipogenic activity of maackiain and ononin is mediated via inhibition of PPARγ in human adipocytes

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 149, P. 112908 - 112908

Published: April 1, 2022

Obesity is a global health burden for which we do not yet have effective treatments prevention or therapy. Plants are an invaluable source of bioactive leads possessing anti-adipogenic potential. Ethnopharmacological use Ononis spinosa L. roots (OSR) treatment obesity and metabolic disorders requires а scientific rationale. The current study examined the capacity OSR its secondary metabolites ononin (ONON) maackiain (MACK) in human adipocytes as vitro model obesity. Both ONON MACK diminished lipid accumulation during adipocyte differentiation. Molecular docking analysis exposed potential interactions between target regulatory adipogenic proteins. Furthermore, results from RT-qPCR disclosed significant upregulation AMPK by treatment. In addition, increased SIRT1, PI3K ACC mRNA expression, while notably downregulated CEBPA, AKT, SREBP1, ADIPOQ. protein level PI3K, C/EBPα, PPARγ adiponectin was reduced upon concentration-dependent manner. Similarly, suppressed abundance. Finally, our provides evidence that exerts effect SIRT1 inhibition adiponectin, induced strong inhibitory on adipogenesis via hampering PPARγ/C/EBPα signaling anti-lipogenic through downregulation SREBP1 ACC. Even though does hamper differentiation, it could be exploited natural with multidirectional mechanism action warrant further validation context vivo models.

Language: Английский

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Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2023, Volume and Issue: Volume 16, P. 4043 - 4064

Published: Dec. 1, 2023

Abstract: Non-alcoholic fatty liver disease(NAFLD) is an umbrella term for a range of diseases ranging from hepatic fat accumulation and steatosis to non-alcoholic steatohepatitis (NASH) in the absence excessive alcohol consumption other definite damage factors. The incidence NAFLD has increased significantly recent years will continue grow coming decades. become huge health problem economic burden. SIRT1 member Sirtuins, group highly conserved histone deacetylases regulated by NAD+, plays vital role regulating cholesterol lipid metabolism, improving oxidative stress, inflammation, insulin resistance through deacetylating some downstream transcription factors thus NAFLD. Although there are no currently approved drugs treating unresolved limitations developing activators, holds promise as proper therapeutic target metabolic diseases. In years, natural products have played increasingly important drug development due their safety efficacy. It been discovered that may be able prevent treat targeting its related pathways. This paper reviews mechanism improvement NALFD regulate associated pathways, discusses potential effectiveness these clinical or dietary supplements. These works provide new ideas directions finding targets anti-NAFLD with good pharmacodynamic properties. Keywords: NAFLD, SIRT1, products, FFA, TG

Language: Английский

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