Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 97, P. 102294 - 102294

Published: April 5, 2024

Language: Английский

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Brain energy metabolism: A roadmap for future research

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 168(5), P. 910 - 954

Published: Jan. 6, 2024

Although we have learned much about how the brain fuels its functions over last decades, there remains still to discover in an organ that is so complex. This article lays out major gaps our knowledge of interrelationships between metabolism and function, including biochemical, cellular, subcellular aspects functional imaging adult brain, as well during development, aging, disease. The focus on unknowns substrates associated transporters, roles insulin lipid droplets, emerging role microglia, mysteries cofactor signaling molecule NAD

Language: Английский

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Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 13, 2025

Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. Different cell types within central nervous system (CNS) can regulate to generate or degrade LDs response diverse pathological stimuli. This article provides a comprehensive review on composition CNS, their generation degradation processes, interaction mechanisms with mitochondria, distribution among different types, roles played by these cells-particularly microglia astrocytes-in various prevalent neurological disorders. Additionally, we also emphasize paradoxical role post-cerebral ischemia inflammation explore potential underlying mechanisms, aiming identify novel therapeutic targets for this disease.

Language: Английский

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Molecular imaging: design mechanism and bioapplications

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(5), P. 1336 - 1383

Published: March 3, 2023

Language: Английский

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Impaired Cholesterol Metabolism, Neurons, and Neuropsychiatric Disorders

Experimental Neurobiology, Journal Year: 2023, Volume and Issue: 32(2), P. 57 - 67

Published: April 30, 2023

Cholesterol metabolism plays an essential role in cellular functions (including as a component of the plasma membrane, energy source, and hormone production) under normal conditions.Dysregulated cholesterol causes wide spectrum pathological conditions, leading to neuropsychiatric disorders, such anxiety depression.In addition, patients with disorders also have impaired metabolism.Therefore, metabolic disturbances are closely associated disorders.Although immune disturbance, neuroinflammation, dysregulated neurotransmitter system, oxidative stress been suggested pathophysiology dysregulation is found psychiatric diseases.As expected, mental illness appear be at risk including syndrome, which influences altered neuronal homeostasis, cell toxicity, death, structures functions, synaptogenesis, neurogenesis, axonogenesis, action potential.Therefore, reversing or abnormal may help restore injury illness.This review aimed discuss links between impairment provides insights into dysfunction due disorders.

Language: Английский

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Contribution of ceramides metabolism in psychiatric disorders

Journal of Neurochemistry, Journal Year: 2023, Volume and Issue: 164(6), P. 708 - 724

Published: Jan. 11, 2023

Psychiatric disorders affect 970 million people worldwide, representing a significant source of disability. Although the underlying neurobiological traits for these are not fully understood, complex interplay between psychological, environmental, and biological factors contributes to their outcomes. Recent advances in lipidomic analysis artificial intelligence algorithms have improved identification selective lipid species modulating susceptibility mental disorders. Sphingolipids (SLs) ceramides-related SLs among most abundant lipids brain that support major key pathways during neurodevelopment plasticity. High levels ceramides plasma contribute psychiatric illness humans animal models. However, neuropathological mechanism regarding involvement remain inconclusive. The is highly susceptible nutritional insults, which could lead functional impairment influence development progression While relies on glucose metabolism its physiological needs, nutrient formula appears greater effects health than others. For instance, consumption high-energy diets associated with anatomical, physiological, metabolic changes, including metabolism. Herein, we will address contribution as modulator such depression, anxiety, bipolar disorder, schizophrenia, attention deficit-hyperactivity disorder. We also describe molecular cellular targets assisting maintenance modulation by dietary formulas non-pharmacologic treatments.

Language: Английский

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Lipid Droplets and Neurodegeneration

Neuroscience, Journal Year: 2024, Volume and Issue: 549, P. 13 - 23

Published: May 6, 2024

Language: Английский

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Arsenic Exposure Induces Neural Cells Senescence and Abnormal Lipid Droplet Accumulation Leading to Social Memory Impairment in Mice

Environmental Pollution, Journal Year: 2025, Volume and Issue: 368, P. 125779 - 125779

Published: Jan. 31, 2025

Language: Английский

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The Inflammatory Mechanism of Parkinson’s Disease: Gut Microbiota Metabolites Affect the Development of the Disease Through the Gut–Brain Axis

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 159 - 159

Published: Feb. 6, 2025

Parkinson's disease is recognized as the second most prevalent neurodegenerative disorder globally, with its incidence rate projected to increase alongside ongoing population growth. However, precise etiology of remains elusive. This article explores inflammatory mechanisms linking gut microbiota disease, emphasizing alterations in and their metabolites that influence disease's progression through bidirectional transmission signals along gut-brain axis. Building on this mechanistic framework, further discusses research methodologies treatment strategies focused metabolites, including metabolomics detection techniques, animal model investigations, therapeutic approaches such dietary interventions, probiotic treatments, fecal transplantation. Ultimately, aims elucidate relationship between underlying thereby paving way for novel avenues condition.

Language: Английский

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The circular RNA circbabo(5,6,7,8S) regulates lipid metabolism and neuronal integrity via TGF-β/ROS/JNK/SREBP signaling axis in Drosophila

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 5, 2025

Lipid droplets (LDs) are dynamic cytoplasmic lipid-storing organelles that play a pivotal role in maintaining cellular energy balance, lipid homeostasis, and metabolic signaling. Dysregulation of metabolism, particularly excessive lipogenesis, contributes to the abnormal accumulation LDs nervous system, which is associated with several neurodegenerative diseases. Circular RNAs (circRNAs) new class non-coding regulatory widely expressed eukaryotes. However, only subset has been functionally characterized. Here, we identified characterized circular RNA circbabo(5,6,7,8S) regulates lipogenesis neuronal integrity Drosophila melanogaster. derived from babo locus encodes type I receptor for transforming growth factor β (TGF-β). Depletion flies causes elevated droplet accumulation, progressive photoreceptor cell loss shortened lifespan, phenotypes rescued by restoring expression. In addition, RNA-seq epistasis analyses reveal these abnormalities caused aberrant activation SREBP signaling pathway. Furthermore, circbabo(5,6,7,8S)-depleted tissues display enhanced TGF-β pathway compromised mitochondrial function, resulting upregulation reactive oxygen species (ROS). Moreover, provide evidence protein circbabo(5,6,7,8S)-p, inhibits interfering assembly babo/put heterodimer complex. Lastly, show dysregulation ROS/JNK/SREBP cascade responsible LD neurodegeneration, lifespan elicited depletion. Our study demonstrates physiological protein-coding circRNA regulating metabolism integrity.

Language: Английский

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