Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Jan. 23, 2023
Introduction
Human
breast
milk
provides
neonates
with
indispensable
nutrition
and
function.
Milk
protein
is
one
of
the
main
constituents
milk.
profiles
can
be
influenced
by
many
factors.
Methods
The
present
study
aimed
to
investigate
difference
in
casein
isolated
from
mature
healthy
mothers
Korean
Han
ethnic
groups
China
using
data-independent
acquisition
(DIA)
proteomics.
Results
A
total
535
proteins
were
identified
quantified
fraction
samples
both
groups.
528
annotated
52
Gene
Ontology
(GO)
terms,
majority
(94.13%)
which
distributed
cell
parts
cellular
component.
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analysis
revealed
that
106
involved
23
pathways,
greatest
(36.79%)
carbohydrate
metabolism.
There
39
differentially
expressed
(DEPs)–10
upregulated
29
downregulated–between
GO
function
blood
microparticles
KEGG
pathway
Staphylococcus
aureus
infection
for
DEPs
most
significantly
enriched
(
p
<
0.05).
Protein-protein
interaction
a
network
47
interactions,
fibrinogen
alpha
chain
ranked
first
as
hub
protein.
Discussion
These
data
may
provide
useful
technical
guidance
development
specific
infant
foods
certain
populations.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(6), P. 1284 - 1290
Published: Sept. 22, 2023
Abstract
Microglia
are
the
main
non-neuronal
cells
in
central
nervous
system
that
have
important
roles
brain
development
and
functional
connectivity
of
neural
circuits.
In
physiology,
highly
dynamic
microglial
processes
facilitated
to
sense
surrounding
environment
stimuli.
Once
switches
its
states,
microglia
recruited
specific
sites
exert
their
immune
functions,
including
release
cytokines
phagocytosis
cellular
debris.
The
crosstalk
between
neurons,
stem
cells,
endothelial
oligodendrocytes,
astrocytes
contributes
functions
synapse
pruning,
neurogenesis,
vascularization,
myelination,
blood-brain
barrier
permeability.
this
review,
we
highlight
neuron-derived
“find-me,”
“eat-me,”
“don’t
eat-me”
molecular
signals
drive
response
changes
neuronal
activity
for
refinement
during
development.
This
review
reveals
mechanism
neuron-microglia
interaction
synaptic
pruning
presents
novel
ideas
disease,
thereby
providing
clues
discovery
target
drugs
disease
treatment
methods
targeting
dysfunction.
Expert Opinion on Drug Discovery,
Journal Year:
2024,
Volume and Issue:
19(5), P. 587 - 602
Published: April 8, 2024
Introduction
Microglia,
the
primary
immune
cells
in
brain,
play
multifaceted
roles
Alzheimer's
disease
(AD).
Microglia
can
potentially
mitigate
pathological
progression
of
AD
by
clearing
amyloid
beta
(Aβ)
deposits
brain
and
through
neurotrophic
support.
In
contrast,
disproportionate
activation
microglial
pro-inflammatory
pathways,
as
well
excessive
elimination
healthy
synapses,
exacerbate
neurodegeneration
AD.
The
challenge,
therefore,
lies
discerning
precise
regulation
contrasting
properties
to
harness
their
therapeutic
potential
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Jan. 23, 2023
Introduction
Human
breast
milk
provides
neonates
with
indispensable
nutrition
and
function.
Milk
protein
is
one
of
the
main
constituents
milk.
profiles
can
be
influenced
by
many
factors.
Methods
The
present
study
aimed
to
investigate
difference
in
casein
isolated
from
mature
healthy
mothers
Korean
Han
ethnic
groups
China
using
data-independent
acquisition
(DIA)
proteomics.
Results
A
total
535
proteins
were
identified
quantified
fraction
samples
both
groups.
528
annotated
52
Gene
Ontology
(GO)
terms,
majority
(94.13%)
which
distributed
cell
parts
cellular
component.
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analysis
revealed
that
106
involved
23
pathways,
greatest
(36.79%)
carbohydrate
metabolism.
There
39
differentially
expressed
(DEPs)–10
upregulated
29
downregulated–between
GO
function
blood
microparticles
KEGG
pathway
Staphylococcus
aureus
infection
for
DEPs
most
significantly
enriched
(
p
<
0.05).
Protein-protein
interaction
a
network
47
interactions,
fibrinogen
alpha
chain
ranked
first
as
hub
protein.
Discussion
These
data
may
provide
useful
technical
guidance
development
specific
infant
foods
certain
populations.
