Conditioned medium derived from human dental pulp stem cells and photobiomodulation improves lipopolysaccharide-induced neuroinflammation, oxidative stress and cognitive impairment in rats DOI Creative Commons
Mohammad Rezaei, Alireza Ebrahimzadeh‐Bideskan, Mahmoud Hosseini

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 20, 2023

Abstract Neuroinflammation has been introduced as a main player in the development of neurodegenerative disorders. Recent studies showed promising anti-inflammatory role for conditioned medium (CM) nervous system. However, order to improve effects CM this study, we investigated effect and photobiomodulation (PBM) on neuroinflammation cognitive disorders caused by it. model was induced lipopolysaccharide (LPS) injection male Wistar rats. Morris water maze (MWM), Passive Avoidance (PA), probe tests were performed assess memory learning function. Levels malondialdehyde (MDA), thiol, superoxide dismutase (SOD) well acetylcholinesterase (AchE) enzyme activity interleukin-6 (IL-6) measured hippocampus tissue stress oxidative inflammation status, respectively. LPS aggrevated status. Employment PBM led significant increase time traveled distance MWM test, duration remaining dark space PA presence test. treatment also improved LPS-induced markers status attenuated IL-6 level AchE activity. Our results propose potential PBM, alone or combination with CM, impairment. The therapeutic capacity application should be further neuroinflammation-induced major

Language: Английский

Gentiopicroside Attenuates Lithium/Pilocarpine-Induced Epilepsy Seizures by Down-Regulating NR2B/CaMKII/CREB and TLR4/NF-κB Signaling Pathways in the Hippocampus of Mice DOI Creative Commons
Miaomiao Tian, Gang Liu,

Juan Du

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1413 - 1413

Published: Oct. 22, 2024

Epilepsy is a prevalent and disabling neurological condition characterized by recurrent seizures. Approximately 50% of adults with active epilepsy have at least one comorbidity they are greater risk premature death than the general population. Gentiopicroside (Gent) primary component

Language: Английский

Citations

0
Photobiomodulation Literature Watch January 2023 DOI
James D. Carroll

Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2023, Volume and Issue: 41(6), P. 300 - 303

Published: May 30, 2023

Language: Английский

Citations

0
Conditioned medium derived from human dental pulp stem cells and photobiomodulation improves lipopolysaccharide-induced neuroinflammation, oxidative stress and cognitive impairment in rats DOI Creative Commons
Mohammad Rezaei, Alireza Ebrahimzadeh‐Bideskan, Mahmoud Hosseini

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 20, 2023

Abstract Neuroinflammation has been introduced as a main player in the development of neurodegenerative disorders. Recent studies showed promising anti-inflammatory role for conditioned medium (CM) nervous system. However, order to improve effects CM this study, we investigated effect and photobiomodulation (PBM) on neuroinflammation cognitive disorders caused by it. model was induced lipopolysaccharide (LPS) injection male Wistar rats. Morris water maze (MWM), Passive Avoidance (PA), probe tests were performed assess memory learning function. Levels malondialdehyde (MDA), thiol, superoxide dismutase (SOD) well acetylcholinesterase (AchE) enzyme activity interleukin-6 (IL-6) measured hippocampus tissue stress oxidative inflammation status, respectively. LPS aggrevated status. Employment PBM led significant increase time traveled distance MWM test, duration remaining dark space PA presence test. treatment also improved LPS-induced markers status attenuated IL-6 level AchE activity. Our results propose potential PBM, alone or combination with CM, impairment. The therapeutic capacity application should be further neuroinflammation-induced major

Language: Английский

Citations

0