Deletion of Setd7 protects against cardiac hypertrophy via inhibiting lipid oxidation DOI Open Access

Haibi Su,

Jinghuan Wang, Yuyu Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract Setd7, a catalytic enzyme responsible for histone H3K4 methylation, is implicated in various cardiac diseases. However, the role of Setd7 pathological hypertrophy remains unclear. In this study, we observed that significantly elevated stimuli cardiomyocytes and mouse failing hearts. Subsequently, found mice lacking remarkably preserved function after transverse aortic constriction, as demonstrated by improving myocardial fibrosis, whereas overexpression deteriorated phenotype. Further vitro analyses revealed mediated-E2F1 activation induces E3 ubiquitin protein ligases WWP2 expression to catalyze lipid-peroxide-reducing GPx4 ubiquitination degradation, ultimately causing widespread lipid peroxidation boosting hypertrophy. Remarkably, loss activity blunted knockdown exerts antihypertrophic effect hypertrophy, further confirming an important Setd7-mediated summary, pressure overload-induced regulated Setd7-E2F1-WWP2-GPx4 signaling pathway, suggesting targeting promising therapeutic strategy attenuate heart failure.

Language: Английский

A Systematic Review on Advances in Management of Oxidative Stress-Associated Cardiovascular Diseases DOI Creative Commons

Soyeon Jin,

Peter M. Kang

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 923 - 923

Published: July 29, 2024

Oxidative stress plays a significant role in the pathogenesis of cardiovascular diseases, such as myocardial ischemia/reperfusion injury, atherosclerosis, heart failure, and hypertension. This systematic review aims to integrate most relevant studies on oxidative management diseases. We searched literatures PubMed database using specific keywords. put emphasis those manuscripts that were published more recently higher impact journals. reviewed total 200 articles. examined current managements including supplements like resveratrol, vitamins C E, omega-3 fatty acids, flavonoids, coenzyme-10, which have shown antioxidative properties potential benefits. In addition, we pharmacological treatments newly discovered antioxidants nanoparticles show effects targeting pathways. Lastly, biomarkers, soluble transferrin receptor, transthyretin, cystatin evaluating antioxidant status identifying risk. By addressing mechanisms, this paper emphasizes importance maintaining balance between oxidants progression is registered with International Platform Registered Systematic Review Meta-analysis Protocols (INPLASY), registration # INPLASY202470064.

Language: Английский

Citations

19
Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Yusheng Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

10
Stem Cell Therapy against Ischemic Heart Disease DOI Open Access
I‐Ting Tsai, Cheuk‐Kwan Sun

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3778 - 3778

Published: March 28, 2024

Ischemic heart disease, which is one of the top killers worldwide, encompasses a series problems stemming from compromised coronary blood supply to myocardium. The severity disease ranges an unstable manifestation ischemic symptoms, such as angina, myocardial death, that is, immediate life-threatening condition infarction. Even though patients may survive infarction, resulting ischemia-reperfusion injury triggers cascade inflammatory reactions and oxidative stress poses significant threat function following successful revascularization. Moreover, despite evidence suggesting presence cardiac stem cells, fact cardiomyocytes are terminally differentiated cannot significantly regenerate after accounts for subsequent progression cardiomyopathy failure, current advancements in medicine. In last two decades, researchers have realized possibility utilizing cell plasticity therapeutic purposes. Indeed, cells different origin, bone-marrow- adipose-derived mesenchymal circulation-derived progenitor induced pluripotent all been shown play roles disease. addition, discovery stem-cell-associated paracrine effects has triggered intense investigations into actions exosomes. Notwithstanding seemingly promising outcomes both experimental clinical studies regarding use against positive results fraud or false data interpretation need be taken consideration. review aimed at overviewing application categories including relevant outcomes, well proposed mechanisms underpinning observations.

Language: Английский

Citations

5
The Pleiotropic Effects of Lipid-Modifying Interventions: Exploring Traditional and Emerging Hypolipidemic Therapies DOI Creative Commons
Dimitris Kounatidis, Nikolaοs Tentolouris, Natalia G. Vallianou

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 388 - 388

Published: July 17, 2024

Atherosclerotic cardiovascular disease poses a significant global health issue, with dyslipidemia standing out as major risk factor. In recent decades, lipid-lowering therapies have evolved significantly, statins emerging the cornerstone treatment. These interventions play crucial role in both primary and secondary prevention by effectively reducing through lipid profile enhancements. Beyond their effects, extensive research indicates that these exhibit pleiotropic actions, offering additional benefits. include anti-inflammatory properties, improvements vascular glucose metabolism, potential implications cancer management. While ezetimibe been extensively studied, newer agents also demonstrate similar even absence of direct This narrative review explores diverse properties lipid-modifying therapies, emphasizing non-lipid effects contribute to burden exploring benefits for non-cardiovascular conditions. Mechanistic insights into actions are discussed alongside therapeutic implications.

Language: Английский

Citations

4
Doxorubicin-Induced Cardiac Remodeling: Mechanisms and Mitigation Strategies DOI
Yingpu Sun, Lili Xiao, Linlin Chen

et al.

Cardiovascular Drugs and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
An update on the role and mechanisms of periodontitis in cardiovascular diseases DOI
Yuping Lai, Sibo Liu,

Chenxin Song

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111770 - 111770

Published: March 1, 2025

Language: Английский

Citations

0
Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies DOI Creative Commons

Xiaoyu Xuan,

Jilin Fan, Jingyi Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Myocardial infarction (MI), which is characterized by high morbidity and mortality, a serious threat to human life health, timely reperfusion therapy save ischemic myocardium currently the most effective intervention. Although effectively restores coronary blood flow maximally limits infarct size, it triggers additional cell death tissue damage, known as myocardial ischemia/reperfusion injury (MIRI). Multiple immune cells are present in area, executing specific functions engaging crosstalk during diverse stages, constituting complex microenvironment involved repair regeneration after MIRI. Immunotherapy brings new hope for treating heart disease modulating microenvironment. In this paper, we explore regulatory roles of various MIRI close relationship between different deaths addition, current status research on targeting system intervene MIRI, with expectation providing basis achieving clinical translation.

Language: Английский

Citations

0
Mitochondrial tRNA-specific Taurine Modifications Correlate With Ferroptosis-associated Myocardial Injury DOI
Yu Pan, Jiancheng Hu,

Xiaorong Ma

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169199 - 169199

Published: May 1, 2025

Language: Английский

Citations

0
Identification and characterization of novel ferroptosis-related genes in acute myocardial infarction DOI Creative Commons

Qiaoyu Zhou,

Ruizheng Shi,

Jia Liu

et al.

Human Genomics, Journal Year: 2024, Volume and Issue: 18(1)

Published: Nov. 13, 2024

Acute myocardial infarction (AMI) is a leading cause of death and morbidity worldwide. Ferroptosis, form regulated cell death, plays critical role in modulating immune functions during AMI. This study aimed to identify ferroptosis-related hub genes that could serve as potential therapeutic targets the progression Bioinformatics was used overlapping associated with ferroptosis infiltration 22 cells by Cell-type Identification Estimating Relative Subsets RNA Transcript (CIBERSORT) analysis. The expression AMI validated across independent datasets, clinical samples, vitro cellular experiments. predictive value for heart failure evaluated first dimension principal component analysis (PCA) using receiver operating characteristic (ROC) identified 11 key significantly correlated abundance. CIBERSORT highlighted dysregulation JDP2, DUSP1, TLR4, NFS1, SLC1A5 were biomarkers progression. Additionally, DDIT4 demonstrated strong long-term failure. highlights association pathogenesis AMI, suggesting molecular mechanisms may underlie acute coronary events.

Language: Английский

Citations

2
Camphene as a Protective Agent in Myocardial Ischemia/Reperfusion Injury DOI Creative Commons
Rodopi Stamatiou,

Maria Anagnostopoulou,

Konstantina Ioannidou-Kabouri

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 405 - 405

Published: March 28, 2024

Myocardial ischemia/reperfusion injury (I/R) and the resulting heart failure is one of main causes mortality morbidity worldwide. Camphene has been shown to have anti-inflammatory hypolipidemic properties; however, its role in protection from ischemia reperfusion not investigated. The cardioprotective camphene mechanism that mediates action against I/R was evaluated present study. A single dose administered adult rats prior ex vivo induction. Infarct size measured using 2,3,5-triphenyltetrazolium chloride (TTC) staining cardiomyocyte assessed by determining release enzyme lactate dehydrogenase (LDH). pretreatment provided significant reducing myocardial infarct cell death after I/R. effect correlated with reduction oxidative stress as evidenced determination protein carbonylation, GSH/GSSG ratio, increase mitochondrial content determined CS activity, modulation antioxidant defense mechanisms (expression Nrf2 target genes activities CAT, MnSOD, GR). Furthermore, ferroptosis decreased, demonstrated downregulation GPx4 expression lipid peroxidation. results suggest can protect maintaining redox homeostasis hold therapeutic potential for mitigating detrimental effects heart.

Language: Английский

Citations

1