Controlled delivery of HIF-1α via extracellular vesicles with collagen-binding activity for enhanced wound healing

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 330 - 347

Published: Feb. 8, 2025

Language: Английский

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Molecular Insights into Ischemia–Reperfusion Injury in Coronary Artery Disease: Mechanisms and Therapeutic Implications: A Comprehensive Review

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 213 - 213

Published: Feb. 13, 2025

Coronary artery disease remains a leading cause of morbidity and mortality worldwide. Acute myocardial infarction results in ischemia-induced cellular dysfunction death. While timely reperfusion limits damage, it paradoxically triggers ischemia-reperfusion injury (IRI), exacerbating tissue damage. IRI, first observed the 1960s, is mediated by complex molecular pathways, including oxidative stress, calcium dysregulation, endothelial dysfunction, inflammation. This review examines emerging therapeutic strategies targeting ischemic preconditioning, postconditioning, pharmacological agents, anti-inflammatory therapies. Preconditioning serves as an endogenous protection mechanism, while postconditioning has become more clinically feasible approach to target inflammation, apoptosis during reperfusion. Pharmacological such GSK-3β inhibitors, JNK mesenchymal stem cell-derived exosomes, have shown promise modulating Wnt/β-catenin NF-κB, reduce enhance recovery. Combination therapies, integrating agents with mechanical provide synergistic further protect mitigate However, translating preclinical findings clinical practice challenging due discrepancies between animal models human conditions, particularly comorbidities diabetes hypertension. Continued research essential refine these optimize application, address translational challenges improve outcomes IRI.

Language: Английский

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Frozen Shoulder as a Metabolic and Immune Disorder: Potential Roles of Leptin Resistance, JAK-STAT Dysregulation, and Fibrosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1780 - 1780

Published: March 6, 2025

Frozen shoulder (FS) is a complex and multifactorial condition characterized by persistent inflammation, fibrosis, metabolic dysregulation. Despite extensive research, the underlying drivers of FS remain poorly understood. Recent findings indicate coexistence pro-inflammatory fibrosis-resolving macrophages within affected tissues, suggesting dysregulated immune response influenced neuroendocrine factors. This review proposes that leptin resistance, hallmark syndrome chronic may play central role in pathogenesis impairing macrophage polarization, perpetuating disrupting fibrosis resolution. The JAK-STAT signaling pathway, critically modulated further contribute to dysregulation sustaining inflammatory activation interfering with tissue remodeling. Additionally, shares pathogenic features fibrotic diseases driven TGF-β signaling, mitochondrial dysfunction, circadian disruption, linking systemic dysfunction localized pathology. Beyond regulation, alterations gut microbiota, bacterial translocation, psychosocial stress exacerbate inflammation imbalances, intensifying resistance. By examining intricate interplay between metabolism, function, remodeling, this highlights targeting sensitivity, modulation, restoration as novel therapeutic strategies for treatment. Future research should explore these interconnections develop integrative interventions address both FS, ultimately improving clinical outcomes.

Language: Английский

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Exosome-based therapies for inflammatory disorders: a review of recent advances

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

Exosomes, small extracellular vesicles secreted by cells, have emerged as focal mediators in intercellular communication and therapeutic interventions across diverse biomedical fields. Inflammatory disorders, including inflammatory bowel disease, acute liver injury, lung neuroinflammation, myocardial infarction, are complex conditions that require innovative approaches. This review summarizes recent advances exosome-based therapies for highlighting their potential diagnostic biomarkers agents. Exosomes shown promise reducing inflammation, promoting tissue repair, improving functional outcomes preclinical models of disorders. However, further research is needed to overcome the challenges associated with exosome isolation, characterization, delivery, well fully understand mechanisms action. Current limitations future directions underscore need enhanced isolation techniques deeper mechanistic insights harness exosomes' full clinical applications. Despite these challenges, hold great treatment disorders may offer a new paradigm personalized medication.

Language: Английский

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Targeting the tumor microenvironment with mesenchymal stem cells based delivery approach for efficient delivery of anticancer agents: An updated review

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116725 - 116725

Published: Dec. 1, 2024

Language: Английский

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Immunomodulatory effect of mesenchymal stem cells‐derived extracellular vesicles to modulate the regulatory T cells and Th1/Th2 imbalance in peripheral blood mononuclear cells of patients with allergic rhinitis

Scandinavian Journal of Immunology, Journal Year: 2024, Volume and Issue: 100(6)

Published: Oct. 29, 2024

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown promising immunomodulatory capabilities for a variety of clinical conditions. However, the potential regulatory mechanisms MSC-EVs in allergic rhinitis (AR) remain unexplored. The present study was designed to investigate effect patients with AR. Peripheral blood mononuclear cells (PBMCs) were isolated from AR patients. number peripheral CD4

Language: Английский

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