Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort

Journal of Antimicrobial Chemotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Objectives This study aimed to predict the impact of different infusion strategies on pharmacokinetic/pharmacodynamic (PK/PD) target attainment and potential risk for toxicity in an ICU cohort treated with β-lactams. Method Using collected patient data from 137 adult patients, applying population PK models, individual parameters were estimated used concentrations following cefotaxime 2 g q8h, piperacillin/tazobactam 4.5 q6h meropenem 1 15 min short infusions (SI), 3 h extended (EI) 24 continuous (CI). The MIC level most common primary pathogens, worst-case scenario (WCS) pathogen, analyses. Results For was reached 94% (129/137) using SI. WCS pathogens meropenem, 78% (65/83) 92% (76/83) SI EI, respectively. However, lower [SI: 31% (17/54), EI: 44% (24/54)]. Overall, number individuals potentially toxic low, both EI (n = 7) 5). CI WCS, 50% (27/54), 96% (54/56) 93% (25/27) cefotaxime, Conclusions In a Swedish rates high regardless strategy. insufficient, suggesting benefit routine use or CI. remained low also might lead unnecessarily concentrations, but well-established levels are lacking future studies warranted.

Language: Английский

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Impact of prolonged versus intermittent infusion of meropenem on mortality and clinical outcomes in patients with severe infection: A systematic review and meta-analysis

Journal of Infection and Chemotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 102634 - 102634

Published: Jan. 1, 2025

Language: Английский

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Antibiotikatherapie schwerer Infektionen in der intensivmedizinischen Praxis

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

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Antibiotic dose optimisation in the critically ill: targets, evidence and future strategies

Current Opinion in Critical Care, Journal Year: 2024, Volume and Issue: 30(5), P. 439 - 447

Published: July 5, 2024

To highlight the recent evidence for antibiotic pharmacokinetics and pharmacodynamics (PK/PD) in enhancing patient outcomes sepsis septic shock. We also summarise limitations of available data describe future directions research to support translation dose optimisation clinical setting.

Language: Английский

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Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis

JAMA, Journal Year: 2024, Volume and Issue: 332(8), P. 623 - 623

Published: June 12, 2024

Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals Network Open Cardiology Dermatology Health Forum Internal Medicine Neurology Oncology Ophthalmology Otolaryngology–Head & Neck Surgery Pediatrics Psychiatry Archives of (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions LibrariansReprints Permissions Terms Use Privacy Accessibility Statement 2024 American Association. All Rights Reserved Search Archive Input Term Sign In Individual inCreate an Account Access through institution Purchase Options: Buy this article Rent Subscribe the journal

Language: Английский

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Detailed regimens for the prolonged β-lactam infusion therapy

Journal of Infection and Chemotherapy, Journal Year: 2024, Volume and Issue: 30(12), P. 1324 - 1326

Published: July 6, 2024

Language: Английский

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Prolonged Beta-lactam Infusions in Children: A Systematic Review and Meta-analysis

The Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 275, P. 114220 - 114220

Published: Aug. 2, 2024

ObjectiveTo assess whether beta-lactam extended or continuous infusions (EI/CI) improve clinical outcomes in children with proven suspected bacterial infections.Study designWe included observational and interventional studies that compared EI CI standard less than 18 years old, reported on mortality, hospital intensive care unit LOS, microbiological cure and/or cure. Data sources PubMed, Medline, EBM Reviews, EMBASE, CINAHL were searched from January 1, 1980, to November 3, 2023. Thirteen (2,945 patients) included: 5 randomized control trials (RCTs), 8 studies. Indications for antimicrobial therapies severity varied, ranging cystic fibrosis exacerbation critically ill bacteriemia.ResultsEI not associated a reduction mortality RCTs (n = 1,464; RR 0.93, 95% 0.71, 1.21), but 833; 0.43, 0.19, 0.96). We found no difference length of stay. Results cures heterogeneous as narrative review. The highly heterogeneous, limiting the strength our findings. lack shared definitions precluded analysis.ConclusionsEI consistently reduced LOS children. conflicting regarding cures. More well-designed targeting high-risk populations are necessary determine efficacy these alternative dosing strategies.

Language: Английский

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An investigation of broad-spectrum antibiotic-induced liver injury based on the FDA Adverse Event Reporting System and retrospective observational study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 6, 2024

Tazobactam/piperacillin and meropenem are commonly used as an empiric treatment in patients with severe bacterial infections. However, few studies have investigated the cause of tazobactam/piperacillin- or meropenem-induced liver injury them. Our objective was to evaluate association between tazobactam/piperacillin intensive care unit patients. We evaluated expression profiles antibiotics-induced using US Food Drug Administration Adverse Event Reporting System (FAERS) database. Further, retrospective observational study, data who initiated were extracted. In FAERS database, male, age, fourth-generation cephalosporin, carbapenem, β-lactam β-lactamase inhibitor combination, complication sepsis associated (p < 0.001). multivariate logistic regression analyses indicated that risk factors for included male = 0.046), administration period ≥ 7 days 0.001), alanine aminotransferase 0.031). Not only but also sex should be considered when clinicians conduct monitoring function receiving meropenem.

Language: Английский

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Reevaluating Piperacillin-Tazobactam Mortality

JAMA Internal Medicine, Journal Year: 2024, Volume and Issue: 184(10), P. 1267 - 1267

Published: Aug. 26, 2024

Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals Network Open Cardiology Dermatology Health Forum Neurology Oncology Ophthalmology Otolaryngology–Head & Neck Surgery Pediatrics Psychiatry Archives of (1919-1959) JN Learning / CMESubscribeJobsInstitutions LibrariansReprints Permissions Terms Use Privacy Accessibility Statement 2024 American Medical Association. All Rights Reserved Search Archive Input Term Sign In Individual inCreate an Account Access through institution Purchase Options: Buy this article Rent Subscribe the journal

Language: Английский

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Specifics of antibiotic treatment in intensive care

Vnitřní lékařství, Journal Year: 2024, Volume and Issue: 70(5), P. 303 - 307

Published: Sept. 4, 2024

Language: Английский

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