Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(9)

Published: April 30, 2025

ABSTRACT Introduction Bone metastases and pathological fractures significantly impact the prognosis quality of life in cancer patients. However, clinical radiological features alone have been shown to fail predict skeletal related events a bone metastasis (SREs). Aim This study focuses on key molecular players including Matrix Metalloproteinases (MMPs), Integrins, Morphogenetic Proteins (BMPs), Parathormone‐related Protein (PTHrP). Results The RANK/RANKL/Osteoprotegerin (OPG) pathway, N‐terminal peptide (NTx), involved metastatic process integrity disruption. Elevated levels these molecules pointed out as potential biomarkers for predicting SREs, but they poorly investigated. Moreover, batimastat, marimastat, tanomastat, andecaliximab, HIV protease targeting MMPs; Volociximab/M200, cilengitide, abituzumab, FAK inhibitors integrins; LDN193189, DMH1, ISLR modulators BMPs; PTH (7–33)‐CBD PTHrP promising results antagonizing molecules, no effect preventing managing has assessed yet. Conclusions paper underscores importance advanced biology transcriptomics identifying novel therapeutic targets. integration with assessments using artificial intelligence tools could revolutionize diagnostics treatment strategies patients metastases.

Language: Английский

Correlation in Stem Cell Technology, Tissue Engineering, and Regenerative Medicine

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский