Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Primary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent advancements in understanding mechanistic role gut microbiota-muscle cross-talk sarcopenia, therapeutic implications. The insights encompass causal dysbiosis potentially mediated through microbiota-derived bioactive metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, their associated signaling pathways, which may be translated into development new microbiome-based treatment diagnostic approaches. Furthermore, identify challenges need addressing future studies to facilitate translation potential novel differential diagnosis older individuals

Language: Английский

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Knowledge, awareness, behaviours, beliefs, attitudes, and perceptions of older Australians regarding muscle health and sarcopenia: A national survey

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: unknown, P. 105835 - 105835

Published: March 1, 2025

This study evaluated older Australians understanding, awareness, knowledge, perceptions, behaviours, beliefs and attitudes towards muscle health sarcopenia, barriers exercise nutrition as prevention options. A national, anonymous 41-question, online purpose-designed survey covering the concepts outlined in objective was conducted from March-May 2024. 1261 adults (≥50-y) aged 50-94 years participated. Low strength poor function were most common criteria associated with health. Knowledge of signs/symptoms, risk factors, consequences, effective treatments generally high. However, there uncertainty about unintentional weight loss a factor, increased for infection/reduced immunity chronic conditions ineffective options (only 5-12 % recognised any form exercise, aerobic eating more fruits/vegetables treatments). Only 8.9 reported their doctor had discussed but 82-95 would act if they received information on factors or informed at Two-thirds sarcopenia serious condition, 48 concerned its potential impact, despite 90 acknowledging is very important to maintain. around half believed sufficient knowledge confidence adopt lifestyle changes reduce risk, motivation leading barrier engaging dietary strategies optimize Older recognize importance health, understand key manage it identified be many lack improve

Language: Английский

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Associations between sleep parameters and falls among older adults with and without cardiovascular disease: Evidence from the China Health and Retirement Longitudinal Study (CHARLS)

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Aim Falls are a major global public health concern, requiring early screening and prevention. Cardiovascular disease (CVD) is associated with physical impairments increased fall risk. Despite the link between CVD sleep parameters, research on falls in patients limited. We aimed to compare correlation populations without develop prevention strategies. Methods This longitudinal cohort study utilized data from China Health Retirement Longitudinal Study (CHARLS). Baseline were collected 2011, follow‐up 2015. assessed based self‐reporting. Sleep including nighttime total duration, daytime napping, disturbance via self‐reported questionnaires. Data analysis was conducted using SPSS R statistical. Results A of 4349 individuals an average age 68.00 ± 5.97 years analyzed. From these individuals, 21.5% reported during follow‐up. significantly ( P < 0.001). After adjusting for multiple factors, durations <6 h = 0.004), 8 9 0.016) >9 0.031) among group. Total duration <7 both non‐CVD groups 0.05). Conclusions Maintaining moderate crucial preventing older adults. Both excessively short long risks, particularly CVD. Geriatr Gerontol Int 2024; ••: ••–•• .

Language: Английский

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Impacts of osteosarcopenia on musculoskeletal health, risks of falls and fractures, and activities of daily living among population aged 50 and above: an age- and sex-matched cross-sectional analysis

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 37(1)

Published: Dec. 27, 2024

Language: Английский

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