A gender perspective on diet, microbiome, and sex hormone interplay in cardiovascular disease DOI Creative Commons
Nina Jovanović, Veronika Zach, Claudia Crocini

et al.

Acta Physiologica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Abstract A unique interplay between body and environment embeds reflects host–microbiome interactions that contribute to sex‐differential disease susceptibility, symptomatology, treatment outcomes. These differences derive from individual biological factors, such as sex hormone action, sex‐divergent immune processes, X‐linked gene dosage effects, epigenetics, well their interaction across the lifespan. The gut microbiome is increasingly recognized a moderator of several systems are thus impacted by its function composition. In humans, components further interact with gender‐specific exposures dietary preferences, stressors, life experiences form complex whole, requiring innovative methodologies disentangle. Here, we summarize current knowledge among hormones, microbiota, system, vascular health relevance for epidemiology cardiovascular diseases. We outline clinical implications, identify gaps, place emphasis on required future studies address these gaps. addition, provide an overview caveats associated conducting research require consideration sex/gender differences. While previous work has inspected separately, here call attention translational utility combined perspective research, gender medicine, biology.

Language: Английский

Suspected sepsis: patient assessment and management in the emergency department DOI

Clare Hird,

Mike Parker

Emergency Nurse, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Sepsis is a potentially life-threatening condition triggered by infection that responsible for an estimated 48,000 deaths in the UK each year. Its pathophysiology complex, its symptomology non-specific and clinical presentations extremely varied. Despite numerous campaigns to raise awareness of sepsis, it still goes undetected. In 2024, National Institute Health Clinical Excellence revised guideline on sepsis Trust published seventh edition Manual. This article discusses how emergency nurses should assess manage patients with suspected sepsis. It describes tools available them, including Early Warning Score 2 6, emphasises importance early antibiotic administration, serial lactate measurements, source control antimicrobial stewardship.

Language: Английский

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Blood microbiome and cardiometabolic disease: insights, therapeutic strategies, and future directions DOI Creative Commons
Ikram Khan, Imran Khan,

Ali Sher Bacha

et al.

Frontiers in Bacteriology, Journal Year: 2025, Volume and Issue: 4

Published: March 3, 2025

Cardiometabolic diseases (CMDs), particularly cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and chronic kidney (CKD), emerged as primary contributors to global morbidity mortality. In addition traditional factors, recent studies demonstrated that blood microbiomes may also promote the development or progression of these CMDs. Traditionally, was considered sterile; however, notion a sterile environment has been challenged by findings demonstrating presence microbiome in both healthy states. Although there tremendous expansion human research, with hundreds projects underway globally not received same level attention its gut oral counterparts. The circulating is an emerging trend drawn high interest biomedical field, given potential generate predictive biomarkers means screen for pathogens. This comprehensive review explores latest advancements emphasizing biomarker identification, diagnostic tools, treatment modalities, prevention We delve into existing challenges present future-oriented strategy using advanced methods. Deciphering microbiome’s role could lead classification patient subgroups, enabling precision microbiota-based therapies.

Language: Английский

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Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy DOI Creative Commons

Cam‐Hoa Mac,

Giang Le Thi Nguyen,

Duy Tân Nguyên

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Sepsis presents a significant medical challenge due to its intense inflammatory response infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates ingestion of piezoelectric particles that adhere stomach lining, specifically targeting TRPV1 receptors. In mouse model sepsis, these particles, when activated by low-intensity pulsed ultrasound, generate mild electrical pulses. These pulses stimulate vagal afferent fibers, transmitting signals brain and modulating neural-immune network via CAIP. Consequently, this leads reduction systemic inflammation, mitigating weight loss, alleviating multiple tissue injuries, preventing death cells spleen. approach addresses critical need for noninvasive sepsis therapies, potentially improving patient outcomes. Utilizing portable ultrasound equipment with minimal thermal effects, technique offers safe convenient treatment option, even home use.

Language: Английский

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0
Targeting mTOR in myeloid cells prevents infection-associated inflammation DOI Creative Commons
Yohana Camila Antunes Frederico, Jazz Munitz, Geoffrey Prévot

et al.

iScience, Journal Year: 2025, Volume and Issue: unknown, P. 112163 - 112163

Published: March 1, 2025

Infections, cancer, and trauma can cause life-threatening hyperinflammation. In the present study, using single-cell RNA sequencing of circulating immune cells, we found that mammalian target rapamycin (mTOR) pathway plays a critical role in myeloid cell regulation COVID-19 patients. Previously, developed an mTOR-inhibiting nanobiologic (mTORi-nanobiologic) efficiently targets cells their progenitors bone marrow. vitro, demonstrated mTORi-nanobiologics potently inhibit infection-associated inflammation human primary cells. Next, investigated vivo effect mouse models hyperinflammation acute respiratory distress syndrome. Using 18F-FDG uptake flow cytometry readouts, mTORi-nanobiologic therapy to reduce hematopoietic organ metabolic activity levels comparable those healthy control animals. Together, show regulating myelopoiesis with is compelling therapeutic strategy prevent deleterious infection-related complications.

Language: Английский

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New insights into the noncanonical inflammasome point to caspase-4 as a druggable target DOI
Elad Elkayam,

François G. Gervais,

Hao Wu

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

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A mouse model of sepsis-associated DIC induced by Kappa-carrageenan and Lipopolysaccharides: Establishment and characteristics DOI Creative Commons
Ping Tang,

Boning Huang,

Quan Ou

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Potential relationship between cuproptosis and sepsis-acquired weakness: an intermediate role for mitochondria DOI Creative Commons

Luying Yang,

Leiyu Xie,

Min Li

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. Skeletal muscle atrophy due critical illness common phenomenon in the intensive care unit (ICU) and referred ICU-acquired weakness (ICU-AW). The occurrence of ICU-AW patients with sepsis known sepsis-acquired (SAW). Furthermore, it well that maintaining normal function closely relates mitochondrial homeostasis. Once impaired, both quality are affected. Copper plays key role homeostasis transition metal regulates stability various enzymes. also involved oxidation-reduction reactions, intracellular copper overload causes oxidative stress induces cell death. Previous studies have shown excess death targeting lipid-acylated proteins regulate tricarboxylic acid (TCA) cycle, which differs from canonical mechanisms regulated inhibitors death, such apoptosis, necroptosis, pyroptosis ferroptosis, not effective preventing copper-induced This new form has been termed “Cuproptosis”; however, mechanism SAW remains unclear. In this paper, we review possible relationship between cuproptosis SAW. Cuproptosis may be regulating pathological through mitochondria-related signaling pathways, ferroptosis mechanisms, genes, provide ideas for further investigations into

Language: Английский

Citations

0
Cyanobacteria-based bioremediation of environmental contaminants: advances and computational insights DOI Creative Commons

Chhavi Dudeja,

Sameen Masroor,

Vinay Kumar Mishra

et al.

Discover Agriculture, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 27, 2025

Language: Английский

Citations

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Somatostatin Mitigates Gastric Mucosal Damage Induced by LPS in a Male Wistar Rat Model of Sepsis DOI Creative Commons
Sergio D. Paredes,

Jorge Hernández-Cortés,

Farzin Falahat

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 508 - 508

Published: March 31, 2025

Upper gastrointestinal bleeding from erosive gastritis remains associated with high mortality in septic or postoperative patients. While stress ulcer has declined, it still occurs patients and is considered a manifestation of intestinal failure within multi-organ syndrome. The integrity the gastric mucosal barrier plays crucial role protection against this condition. Somatostatin (SS) appears as biomolecule cytoprotective properties. We aimed to investigate whether SS treatment protected mucosa rat model lipopolysaccharide (LPS)-induced sepsis. Rats received LPS (10 mg/kg) intraperitoneally, followed by saline (200 μg/kg; 5 mL/kg) after 30 min (early group) 120 (late group). Control rats only saline. Two hours administration (total procedure duration 150 240 min), lavage, mucosa, plasma samples were collected for analysis. mitigated LPS-induced disruption preserving phosphatidylcholine (PC) levels, well decreasing leukocyte infiltration marker myeloperoxidase (MPO), inflammation-related enzyme phospholipase A2 (PLA2), lipid peroxidation indicator malondialdehyde (MDA). also reduced arachidonic acid-related metabolites thromboxane B2 (TXB2) leukotriene B4 (LTB4) while increasing prostaglandin I2 (PGI2). effectively maintained integrity, reducing inflammation, modulating acid metabolites. These findings suggest that may serve therapeutic agent inflammation injury.

Language: Английский

Citations

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Lanreotide protects against LPS-induced inflammation in endothelial cells and mouse lungs DOI
Md Matiur Rahman Sarker,

Saikat Fakir,

Khadeja-Tul Kubra

et al.

Tissue Barriers, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Somatostatin is expressed in various tissues - including the hypothalamus and strongly suppresses Growth Hormone levels to maintain homeostasis. Synthetic somatostatin analogs are currently used clinics treat neuroendocrine tumors acromegaly. An emerging body of evidence suggests that those synthetic peptides exert anti-inflammatory activities. The present study examines effect Lanreotide (LAN) on Lipopolysaccharide (LPS)-triggered injury endothelial cells mice. Our findings indicate LAN effectively mitigates LPS-induced hyperpermeability, inflammation, reactive oxygen species (ROS) generation bovine pulmonary artery (BPAEC) human lung microvascular (HULEC-5a). A murine model acute was also utilized, examine effects edema inflammation. observations suggest myosin light chain 2 (MLC2), Cofilin, extracellular signal-regulated kinase 1/2 (ERK1/2), STAT1, STAT3, P38 activation; edema. In conclusion, based aforementioned observations, it suggested counteracts experimental

Language: Английский

Citations

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