Genome-wide profiling of long non-coding RNA following ozone exposure: a randomized, controlled exposure trial DOI
Ying Fang, Xihao Du,

X. Ji

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120101 - 120101

Published: Oct. 1, 2024

Language: Английский

Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes DOI Creative Commons
Wadih Issa, Rachel Njeim,

Arianna Carrazco

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1157 - 1157

Published: July 6, 2024

Accumulating evidence indicates that inflammatory and immunologic processes play a significant role in the development progression of glomerular diseases. Podocytes, terminally differentiated epithelial cells, are crucial for maintaining integrity filtration barrier. Once injured, podocytes cannot regenerate, leading to progressive proteinuric However, emerging suggests not only maintain barrier important targets immune responses but also exhibit many features immune-like where they involved modulation activity innate adaptive immunity. This dual may lead discovery new therapeutic treating review aims provide an overview immunity mechanisms podocyte injury

Language: Английский

Citations

4
Automation and Decision Support in the Area of Nephrology Using Numerical Algorithms, Artificial Intelligence, and Expert Approach: Review of the Current State of Knowledge DOI Creative Commons
Dawid Pawuś, Tomasz Porażko, Szczepan Paszkiel

et al.

IEEE Access, Journal Year: 2024, Volume and Issue: 12, P. 86043 - 86066

Published: Jan. 1, 2024

Language: Английский

Citations

3
Temporal changes in blood metabolome among hemodialysis patients DOI Creative Commons
Shereen M. Aleidi, Anas M. Abdel Rahman

Kidney International Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Identification and validation of biomarkers in membranous nephropathy and pan-cancer analysis DOI Creative Commons
Yue Yang,

Guming Zou,

Xian-sen Wei

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Background Membranous nephropathy (MN) is an autoimmune disease and represents the most prevalent type of renal pathology in adult patients afflicted with nephrotic syndrome. Despite substantial evidence suggesting a possible link between MN cancer, precise underlying mechanisms remain elusive. Methods In this study, we acquired integrated two datasets (comprising single-cell dataset bulk RNA-seq dataset) from Gene Expression Omnibus database for differential expression gene (DEG) analysis, hub genes were obtained by LASSO random forest algorithms, diagnostic ability was assessed using ROC curves, degree immune cell infiltration evaluated ssGSEA function. Concurrently, gathered pan-cancer-related TCGA GTEx databases, to analyze expression, mutation status, drug sensitivity prognosis pan-cancer. Results We conducted intersections set 318 senescence-related 366 DEGs, resulting identification 13 DEGs. Afterwards, meticulously analyzed these which ultimately led discovery six through intersection ( PIK3R1 , CCND1 TERF2IP SLC25A4 CAPN2 TXN ). curves suggest that have good recognition MN. After performing correlation examining infiltration, conducting comprehensive pan-cancer investigation, validated immunohistochemical analysis human biopsy tissues. The notably accentuates robust association prognoses individuals diverse cancer types, further underscoring importance mutations within across various cancers. Conclusion This indicates could potentially play pivotal role as critical connecting cancer. As result, they may hold promise valuable targets intervention cases both

Language: Английский

Citations

2
Multi-scalar data integration decoding risk genes for chronic kidney disease DOI Creative Commons

Shiqi Ding,

Jing Guo,

Huimei Chen

et al.

BMC Nephrology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 18, 2024

Chronic Kidney Disease (CKD) impacts over 10% of the global population, and recent advancements in high-throughput analytical technologies are uncovering complex physiology underlying this condition. By integrating Genome-Wide Association Studies (GWAS), RNA sequencing (RNA-seq/RNA array), single-cell (scRNA-seq) data, our study aimed to explore genes cell types relevant CKD traits. GWAS summary data for end-stage renal failure (ESRD) decreased eGFR with or without diabetes (micro)proteinuria were obtained from Catalog UK Biobank (UKB) database. Two gene Expression Omnibus (GEO) transcriptome datasets used establish glomerular tubular expression differences between patients healthy individuals. scRNA-seq utilized obtain key at level. The profile, differentially expressed (DEGs), gene-gene interaction, pathway enrichment analysed these risk genes. A total 779 distinct SNPs identified across different traits, involving 681 While many specific traits failure, eGFR, (micro)proteinuria, they share common pathways, including extracellular matrix (ECM). ECM modeling was enriched upregulated DEGs kidneys compared controls, collagen genes, such as COL1A2, prevalent fibroblasts/myofibroblasts. Additionally, immune responses, T differentiation, dysregulated kidneys. late podocyte signature THSD7A podocytes but downregulated CKD. We also highlighted that regulated mainly cells kidney. Our integrated analysis highlight associational pathogenesis kidney a basis further mechanistic studies understand

Language: Английский

Citations

2
Genome-wide profiling of long non-coding RNA following ozone exposure: a randomized, controlled exposure trial DOI
Ying Fang, Xihao Du,

X. Ji

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120101 - 120101

Published: Oct. 1, 2024

Language: Английский

Citations

0