Decoding the research landscape of drug resistance and therapeutic approaches in head and neck cancer: a bibliometric analysis from 2000 to 2023

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 5, 2024

Head and neck cancer is one of the most common tumors worldwide. However, drug resistance in its treatment has become a major factor limiting efficacy. This study aims to comprehensively understand current status research this field. The analyzes papers related therapeutic head published between 2000 2023 Web Science Core Collection To achieve objectives, we searched WoSCC for review on from 2023, screened English literature, analyzed hotspots, academic collaborations, trends detail using tools such as Citespace, SCImago Graphica, VOS viewer. summarizes 787 publications WoSCC. analysis showed that China United States are contributors field, Grandis Jennifer R Yang Jai-Sing key scholars. Keyword "cisplatin resistance" continuing focus attention, while "Metastasis" "Ferroptosis" may be emerging hotspots. Literature clustering pointed out "Ferroptosis", "Immunotherapy" "ERK signaling" were recent hotspots received extensive attention citations. Finally, discuss challenges drug-resistant therapies cancer. first comprehensive bibliometric Reveals helps researchers grasp cutting-edge

Language: Английский

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AlzONet: a deep learning optimized framework for multiclass Alzheimer’s disease diagnosis using MRI brain imaging

The Journal of Supercomputing, Journal Year: 2025, Volume and Issue: 81(2)

Published: Jan. 23, 2025

Language: Английский

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Catalpalactone protects rats nerve function from hypoxic lesion by polarizing microglial cells toward M2 phenotype

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 12, 2025

Ischemic brain injury results in high disability due to neuroinflammation and oxidative stress, M1/M2 polarization of glial cells plays a key role neuroinflammation. This research explored the protective effect Catalpalactone on middle cerebral artery occlusion (MCAO)-induced its underlying regulation mechanism rats. The ischemic lesions were induced by MCAO, oxygen glucose deprivation/reoxygenation (OGD/R) was used for BV2 microglial cell induction. determined via immunohistochemistry staining assessment. Oxygen consumption rate (OCR) extracellular acidification (ECAR) assays glycolysis phosphorylation test. After that, counting kit-8 (CCK-8) viability test flow cytometry apoptosis analysis performed. Furthermore, co-culture model PC12 purpose exploring effects interaction microglia neurons injury. Finally, Modified Neurological Severity Score (mNSS) neurological function. MCAO induction, infiltration significantly increased area, M1 phenotype enhanced (up-regulated Cd86). In vitro, OGD/R-induced also exhibited increasing with higher activity, but lower through activating JAK-SATA signaling pathway. we that 15 μM optimally induces M2 decreased model, while reducing mNSS scores improving function rat model. We clarified treatment promoting phenotype.

Language: Английский

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The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 27, 2025

Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.

Language: Английский

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Bibliometric analysis and knowledge mapping of diabetes mellitus combined with tuberculosis research: trends from 1995 to 2023

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Background The synergistic epidemic of diabetes mellitus and tuberculosis (DM-TB) has created a dual disease burden, challenging global health systems with complex pathophysiological interactions suboptimal treatment outcomes. To decode the evolving research landscape, this study presents latest comprehensive bibliometric analysis mapping intellectual architecture DM-TB over three decades. Methods We systematically analyzed 791 peer-reviewed articles from Web Science Core Collection (1995-2023) using CiteSpace, VOSviewer, Bibliometrix. Advanced metrics including co-citation networks, keyword burst detection, institutional collaboration patterns were employed to identify paradigm-shifting trends. Results Three distinct growth phases observed: initial stagnation (1995-2007, <10 annual publications), exponential (2008-2019), diversification (2020-2023). United States dominated scientific output (27.3% total while London School Hygiene & Tropical Medicine emerged as central hub for international collaborations (TLS=176). Keyword evolution revealed transformative phases: (1) Pathomechanistic exploration (1995-2016): Focused on hyperglycemia-immunity interplay epidemiological surveillance; (2) Translational innovation (2017-2020): Shifted preclinical models, pharmacokinetic optimization, multidrug resistance; (3) Precision medicine era (2021-2023): Emerging hotspots in latent TB screening (burst strength=6.82), metformin-mediated immunomodulation, AI-driven diagnostic biomarkers. Conclusion Beyond delineating historical trajectories, identifies critical knowledge gaps inflammation-resolution mechanisms insulin resistance pathways, proposing roadmap targeted biomarker discovery policy formulation. constructed framework empowers strategic resource allocation combating syndemic.

Language: Английский

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Panaroma of microglia in traumatic brain injury: a bibliometric analysis and visualization study during 2000–2023

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Nov. 7, 2024

Background Traumatic brain injury (TBI) is a critical global health concern characterized by elevated rates of both morbidity and mortality. The pathological physiological changes after TBI are closely related to microglia. Microglia, the primary immune cells in brain, linked mechanisms treatment TBI. With increasing research this area, study employs bibliometric analysis identify current hotspots predict future trends. Objective We decided perform provide comprehensive overview advancements microglia traumatic injury. aim offer researchers insights into trends directions. Method collected all articles reviews published between 2000 2023 from Web Science Core Collection. These records were analyzed using VOSviewer, CiteSpace, R package “bibliometrix”. Results retrieved 665 publications 25 countries, with majority contributed United States China. number on has been steadily each year. Our highlighted Journal Neurotrauma Neuroinflammation as most influential journals field. Alan I. Faden David J. Loane recognized leading contributors. Keyword indicates that neuroinflammation, microglial polarization, neurodegenerative diseases pivotal areas for research. Conclusion In recent years, TBI-related proliferated, studies primarily focusing involvement changes, polarization following Since neuroinflammation neurodegeneration two hallmark features TBI, targeting may become central focus

Language: Английский

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Advances of induced pluripotent stem cells in Alzheimer’s disease: A bibliometric analysis

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: June 30, 2024

Objective: Alzheimer’s disease (AD), as a progressive neurological disorder that primarily affects memory, thinking skills, and behavior, is the most common cause of dementia, but there no cure for AD. Induced pluripotent stem cells (iPSCs) therapy, an emerging therapeutic strategy, brings new hope treatment these diseases. This study aims to explore research hotspots, development trends future directions iPSCs therapy in Methods: By quantitatively analyzing relevant literature, we screened all Science Citation Index Expanded (SCI-EXPANDED) Social Sciences (SSCI) related literature about AD from 1900-2024 Web Science, analyzed this field by using VOSviewer bibliometric analysis online platforms etc. Results: A total 718 were Core Collection database according search strategy. Bibliometric revealed number publications on has shown growing trend, with annual average more than 90 over past five years, which hot spot recent years. Notably, Li-Huei Tsai productive influential author field. Harvard Medical School ranks institution largest publications, while Stem Cell Research stands out journal topic. Furthermore, United States makes contribution Conclusions: been become research, main contributor States.

Language: Английский

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A bibliometric analysis of transformative learning research: trends and developments from 1992 to 2023

Cogent Education, Journal Year: 2024, Volume and Issue: 11(1)

Published: Oct. 7, 2024

The field of transformative learning has garnered significant attention from researchers and practitioners in adult education due to its potential address the complex unpredictable challenges societal change. This study employs a bibliometric approach, analyzing data Scopus database covering years 1992 2023, identifying total 3412 research documents this field. analysis reveals several key findings. Firstly, as experienced substantial growth, with marked increase number publications over time. Secondly, there is notable trend towards increased collaboration among authors countries, including both developing nations those Eastern part world. Thirdly, themes within are evolving, encompassing theoretical concepts extending practical implementations. These findings provide comprehensive overview development future directions research, highlighting contributions collaborative efforts academic community. implications suggest need for ongoing exploration integration principles across diverse disciplines contexts.

Language: Английский

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Bibliometric and visual analysis of single-cell multiomics in neurodegenerative disease arrest studies

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Background Neurodegenerative diseases are progressive disorders that severely diminish the quality of life patients. However, research on neurodegenerative needs to be refined and deepened. Single-cell polyomics is a technique for obtaining transcriptomic, proteomic, other information from single cell. In recent years, heat single-cell multiomics as an emerging tool brain science has gradually increased. Therefore, aim this study was analyze current status trends studies related application in through bibliometrics. Result A total 596 publications were included bibliometric analysis. Between 2015 2022, number increased annually, with citations increasing significantly, exhibiting fastest rate growth between 2019 2022. The country/region collaboration map shows United States most cumulative citations, China have collaborations. institutions produced greatest articles Harvard Medical School, Skupin, Alexander, Wiendl. Among authors, Heinz had highest output. Mathys, H accumulated authoritative author field. journal Nature Communications published literature keyword analysis reveals lesions (e.g., Alzheimer’s disease, amyloid beta) core foundation Conversely, RNA sequencing, bioinformatics) nerve cells microglia, astrocytes, neural stem cells) hot frontiers specialty. references, article “Single-cell transcriptomic disease” frequently cited (1,146 citations), “Cell types mouse cortex hippocampus revealed by RNA-seq” Conclusion objective employ methods visualize diseases. This will enable us summarize state reveal key hotspots

Language: Английский

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Identification of walnut-derived peptide WNP-8 as a potential therapeutic agent and SIRT2 as a biomarker for cognitive deficiency: A label-free LC-MS/MS proteomics study

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138432 - 138432

Published: Dec. 7, 2024

Language: Английский

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