BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 21, 2024
Language: Английский
Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899
Published: July 9, 2024
This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.
Language: Английский
Citations
62
Results in Engineering, Journal Year: 2024, Volume and Issue: 23, P. 102720 - 102720
Published: Aug. 10, 2024
Nanostructured CeO2 was fabricated through a facile sonochemical route utilizing cerium (III) nitrate hexahydrate as metal source and mentha extract novel capping agent. To our knowledge, this experimental work is the first successful endeavor for fabricating nanostructured employing by an easy eco-friendly route. The microstructure various characteristics of oxide nanostructure prepared were investigated using methods. This research examined anticancer effects green synthesized nanoparticles (CeO2-NPs) on cancer cell lines (T98 SHSY5Y) at several concentrations 0.0, 0.05, 0.1, 0.2, 0.4, 0.8 mg/ml NPs exposure time 24/48 h. obtained results presented cytotoxicity against cancerous lines. Considering CeO2-NP's cells indicated significant toxicity lines, these could be applied in medicine developing new drug formulations Additional investigations are desired to reveal other biological applications normal
Language: Английский
Citations
25
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 24, 2025
Language: Английский
Citations
1
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 27, 2025
Ferroptosis and cuproptosis can be summarized as metal-dependent cell death. This study aimed to explore the expression of death resistance (MCDR) characteristics in tumor cells oral squamous carcinoma (OSCC) its relationship with lymph node metastasis (LNM). By integrating single-cell data OSCC from public databases, an matrix comprising 127,149 was constructed. Gene set scores were calculated using irGSEA package, GO KEGG analyses performed identify enriched pathways. The R package monocle3 employed calculate trajectory infer evolutionary patterns. MuSiC2 enable evaluation proportions. Cell-cell interaction information analyzed CellChat package. cathepsin V (CTSV), glutathione peroxidase 4 (GPX4), cyclin-dependent kinase inhibitor 2A (CDKN2A) validated via immunohistochemistry multiplex mucosa (OM), non-metastatic primary tumors (nPT), metastatic (mPT). Additionally, oncoPredict utilized potential drug sensitivities. malignant divided into five subtypes, among which Epi_2 existed more mPT had higher MCDR characteristics. In addition, multiple malignant-related pathways such HEDGEHOG, NOTCH, MYC. spatial transcriptome bulk RNA verified that proportion than nPT. Cell communication analysis showed effect on endothelial enhanced, mainly reflected VEGFR CXCL signaling Immunohistochemical results characteristic markers CTSV GPX4 significantly Multiplex immunohistochemical co-expression CTSV, CDKN2A those patients high may have immunotherapy anti-EGFR treatment resistance. Doramapimod identified a sensitive drug. There is type MDCR OSCC, related LNM It provides predictive marker for early diagnosis LNM.
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36608 - e36608
Published: Aug. 23, 2024
Language: Английский
Citations
6
Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 40, P. 101399 - 101399
Published: Nov. 4, 2024
Language: Английский
Citations
6
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 23, 2025
Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.
Language: Английский
Citations
0
Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: 337, P. 130624 - 130624
Published: Feb. 26, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Dec. 2, 2024
Controlled drug delivery systems have been intensively researched for cancer treatment to increase precision targeting and therapeutic efficacy. In this context, novel magnetic-/pH-sensitive graphene oxide/chitosan/iron oxide magnetic nanocomposite microspheres were synthesized. Fe3O4 (IO) nanoparticles (NPs) synthesized via the green synthesis method in presence of Salvia officinalis extract. The (GO) NPs prepared using Staudenmaier method, materials characterized. Chitosan (CS) was used prepare microspheres. GO/CS/IO investigated as prospective vehicles controlled temozolomide absence an external field. release percentage molecules 100 Hz reached a maximum 90 min. This is approximately twice amount field more than that 50 Also, highest degree swelling observed at pH 4.5, higher 7.4. MTT assay results indicated cytotoxicity glioblastoma cells; notably, significant difference between groups exposed those not, with exposure further reducing survival. These potentially apply systems.
Language: Английский
Citations
3
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0303359 - e0303359
Published: May 10, 2024
As-produced carbon nanotubes contain impurities which can dominate the properties of material and are thus undesired. Herein we present a multi-step purification treatment that combines use steam hydrochloric acid in an iterative manner. This allows reduction iron content down to 0.2 wt. % samples single-walled (SWCNTs). Remarkably, Raman spectroscopy analysis reveals this strategy does not introduce structural defects into SWCNTs’ backbone. To complete study, also report on simplified approach for quantitative assessment using UV-Vis spectroscopy. The amount metal SWCNTs is assessed by dissolving HCl residue obtained after combustion sample. leads creation hexaaquairon(III) chloride determination iron, from catalyst, main advantage proposed it require additional complexing agents.
Language: Английский
Citations
2