Vitamin D status in children with COVID-19: does it affect the development of long COVID and its symptoms? DOI Creative Commons
Vita Perestiuk,

Tetyana Kosovska,

O.M. Dyvoniak

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 14, 2025

Long COVID is characterized by diverse symptoms persisting after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the immunomodulatory and neuroprotective properties of vitamin D, understanding its role in long growing interest. This study aimed to determine D status children with COVID-19 assess impact on clinical course disease development. A prospective cohort included hospitalized confirmed COVID-19, aged 1 month 18 years, diagnosed between September 2022 March 2024. Serum 25-hydroxyvitamin (25(OH)D) concentrations were measured upon hospital admission, follow-up was done identify symptoms. In total, 162 patients examined. Vitamin deficiency determined 8.0%, insufficiency 25.3%, optimal levels 66.7% COVID-19. deficiency/insufficiency observed 73% over 6 years 21.6% under age. Comorbid conditions 1.4 times more frequent insufficiency, undernutrition obesity playing most significant roles (p = 0.0023, p 0.0245, respectively). 25(OH)D concentration depends severity 0.0405) had a longer stay (4 vs. 3 days, 0.0197). The affected median neutrophils, lymphocytes, their ratio, prothrombin time, fibrinogen levels, frequency increased immunoglobulins M E levels. Among 134 who agreed follow up, 56 (41.8%) experienced symptoms, while 78 (58.2%) recovered fully. frequently 0.0331). odds developing 2.2 higher 0.0346) compared those Children often exhibited neurological (80% 41.9%, 0.0040) musculoskeletal (16% 0%, 0.0208). depended affect influenced duration hospitalization. There an risk deficiency/insufficiency, development associated established.

Language: Английский

Vitamin D status in children with COVID-19: does it affect the development of long COVID and its symptoms? DOI Creative Commons
Vita Perestiuk,

Tetyana Kosovska,

O.M. Dyvoniak

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 14, 2025

Long COVID is characterized by diverse symptoms persisting after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the immunomodulatory and neuroprotective properties of vitamin D, understanding its role in long growing interest. This study aimed to determine D status children with COVID-19 assess impact on clinical course disease development. A prospective cohort included hospitalized confirmed COVID-19, aged 1 month 18 years, diagnosed between September 2022 March 2024. Serum 25-hydroxyvitamin (25(OH)D) concentrations were measured upon hospital admission, follow-up was done identify symptoms. In total, 162 patients examined. Vitamin deficiency determined 8.0%, insufficiency 25.3%, optimal levels 66.7% COVID-19. deficiency/insufficiency observed 73% over 6 years 21.6% under age. Comorbid conditions 1.4 times more frequent insufficiency, undernutrition obesity playing most significant roles (p = 0.0023, p 0.0245, respectively). 25(OH)D concentration depends severity 0.0405) had a longer stay (4 vs. 3 days, 0.0197). The affected median neutrophils, lymphocytes, their ratio, prothrombin time, fibrinogen levels, frequency increased immunoglobulins M E levels. Among 134 who agreed follow up, 56 (41.8%) experienced symptoms, while 78 (58.2%) recovered fully. frequently 0.0331). odds developing 2.2 higher 0.0346) compared those Children often exhibited neurological (80% 41.9%, 0.0040) musculoskeletal (16% 0%, 0.0208). depended affect influenced duration hospitalization. There an risk deficiency/insufficiency, development associated established.

Language: Английский

Citations

0