Targeting the immuno-inflammatory-microbial network: a key strategy for sepsis treatment DOI Creative Commons
Yue Xu, Jiaxin Wang, Rui Yuan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Sepsis is a life-threatening condition caused by dysregulated host response to infection, remaining major global health challenge despite clinical advances. Therapeutic challenges arise from antibiotic misuse, incomplete understanding of its complex pathophysiology, and the unresolved interplay immune dysregulation microbiota disruption. Investigating microbial homeostasis in shift cytokine storm immunosuppression may elucidate between metabolites, dysfunction, organ injury, providing foundation for targeted therapies drug development. Traditional Chinese Medicine (TCM) has demonstrated significant advantages mitigating sepsis-associated storms modulating gut homeostasis, offering promising strategy developing highly effective less toxic monomeric compounds. Elucidating interactions within immune-inflammation-microbiota network sepsis paves way biomarker-driven personalized therapeutic approaches.

Language: Английский

Comparison of transvesicoscopic Cohen and transvesicoscopic Politano-Leadbetter ureteral reimplantation in the treatment of ureterovesical junction obstruction (UVJO) in children: a single-center long-term follow-up study DOI Creative Commons

Guanglun Zhou,

Yefeng Zeng,

Sung‐Tzu Liang

et al.

Pediatric Surgery International, Journal Year: 2025, Volume and Issue: 41(1)

Published: March 31, 2025

Language: Английский

Citations

0
Targeting the immuno-inflammatory-microbial network: a key strategy for sepsis treatment DOI Creative Commons
Yue Xu, Jiaxin Wang, Rui Yuan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Sepsis is a life-threatening condition caused by dysregulated host response to infection, remaining major global health challenge despite clinical advances. Therapeutic challenges arise from antibiotic misuse, incomplete understanding of its complex pathophysiology, and the unresolved interplay immune dysregulation microbiota disruption. Investigating microbial homeostasis in shift cytokine storm immunosuppression may elucidate between metabolites, dysfunction, organ injury, providing foundation for targeted therapies drug development. Traditional Chinese Medicine (TCM) has demonstrated significant advantages mitigating sepsis-associated storms modulating gut homeostasis, offering promising strategy developing highly effective less toxic monomeric compounds. Elucidating interactions within immune-inflammation-microbiota network sepsis paves way biomarker-driven personalized therapeutic approaches.

Language: Английский

Citations

0