Exosomes: their role and therapeutic potential in overcoming drug resistance of gastrointestinal cancers DOI Creative Commons

J Liu,

Shanyu Gao,

Xiaoming Liu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 13, 2025

Gastrointestinal cancers are prevalent malignant neoplasms in clinical medicine. The development of drug resistance gastrointestinal result tumor recurrence and metastasis greatly diminish the efficacy treatment. Exosomes, as shuttle intercellular molecular cargoes micro-environment, secreted from stromal cells mediate by regulating epithelial-mesenchymal transition, efflux, stem-like phenotype cell metabolism. Meanwhile, exosomes have already received tremendous attention biomedical study potential resistant biomarkers well treatment strategy cancers. Primary challenge to implement this is ability obtain high-grade efficiently; however, lack standard protocols for their processing characterization. Furthermore, field suffers insufficient standardized reference materials workflow purification, detection analysis with defined biological properties. This review summarize unique biogenesis, composition novel methods informed underlying correlation between Moreover, applications also summarized, might providing therapy individual

Language: Английский

Exosomes: their role and therapeutic potential in overcoming drug resistance of gastrointestinal cancers DOI Creative Commons

J Liu,

Shanyu Gao,

Xiaoming Liu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 13, 2025

Gastrointestinal cancers are prevalent malignant neoplasms in clinical medicine. The development of drug resistance gastrointestinal result tumor recurrence and metastasis greatly diminish the efficacy treatment. Exosomes, as shuttle intercellular molecular cargoes micro-environment, secreted from stromal cells mediate by regulating epithelial-mesenchymal transition, efflux, stem-like phenotype cell metabolism. Meanwhile, exosomes have already received tremendous attention biomedical study potential resistant biomarkers well treatment strategy cancers. Primary challenge to implement this is ability obtain high-grade efficiently; however, lack standard protocols for their processing characterization. Furthermore, field suffers insufficient standardized reference materials workflow purification, detection analysis with defined biological properties. This review summarize unique biogenesis, composition novel methods informed underlying correlation between Moreover, applications also summarized, might providing therapy individual

Language: Английский

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