Small Ruminant Research, Journal Year: 2024, Volume and Issue: unknown, P. 107405 - 107405
Published: Nov. 1, 2024
Language: Английский
Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2024, Volume and Issue: 51(8), P. 866 - 876
Published: April 5, 2024
Language: Английский
Citations
7
Animals, Journal Year: 2024, Volume and Issue: 14(13), P. 1928 - 1928
Published: June 29, 2024
The Istrian (IS) and the Pag sheep (PS) are local Croatian breeds which provide significant income for regional economy have a cultural traditional importance inhabitants. aim of this study was to estimate some important population specific genetic parameters in IS (N = 1293) PS 2637) based on genome wide SNPs. Estimates linkage disequilibrium effective size (Ne) evidenced more variability (Ne 838) compared 197), regardless historical time (both recent ancient variability). discrepancy between these additionally confirmed by estimates genomic inbreeding (FROH), estimated be notably higher (FROH>2 0.062) than 0.029). average FROH2–4, FROH4–8, FROH8–16, FROH>16 were 0.26, 1.65, 2.14, 3.72 0.22, 0.61, 0.75, 1.58 PS, thus evidencing high contribution overall inbreeding. One ROH island with > 30% SNP incidence ROHs detected (OAR6; 34,253,440–38,238,124 bp) while there no islands PS. Seven genes (CCSER1, HERC3, LCORL, NAP1L5, PKD2, PYURF, SPP1) involved growth, feed intake, milk production, immune responses, resistance associated found autozygosity. results represent first comprehensive insight into two will serve as baseline setting up most promising strategy Optimum Contribution Selection.
Language: Английский
Citations
5
Animals, Journal Year: 2024, Volume and Issue: 14(2), P. 273 - 273
Published: Jan. 15, 2024
Multi-omics-integrated analysis, known as panomics, represents an advanced methodology that harnesses various high-throughput technologies encompassing genomics, epigenomics, transcriptomics, proteomics, and metabolomics. Sheep, playing a pivotal role in agricultural sectors due to their substantial economic importance, have witnessed remarkable advancements genetic breeding through the amalgamation of multiomics analyses, particularly with evolution technologies. This integrative approach has established robust theoretical foundation, enabling deeper understanding sheep genetics fostering improvements strategies. The comprehensive insights obtained this shed light on diverse facets development, including growth, reproduction, disease resistance, quality livestock products. review primarily focuses application principal omics analysis sheep, emphasizing correlation studies between data specific traits such meat quality, wool characteristics, reproductive features. Additionally, paper anticipates forthcoming trends potential developments field.
Language: Английский
Citations
4
BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 12, 2025
Dairy goats, a livestock species with long history of milk production, are essential for the economic advancement nations, particularly in regions experiencing growth. In this study, we gathered whole-genome resequencing data 58 including 34 dairy goats and 24 wild (Bezoar), to explore selection signatures linked production traits using ROH (Runs homozygosity), CLR (composite likelihood ratio), Fst (Fixation index), XP-EHH (Ex-tended haplotype homozygosity across populations) XP-CLR(Cross-population composite ratio test) methods. Analysis five tests revealed total 210 genes, genes consistently identified at least two approaches. These associated fat, protein, fat yield. Gene enrichment analysis highlighted important GO KEGG pathways related such as "acyl-CoA metabolic process", "glycerolipid biosynthetic "cellular response fatty ac-id", "hormone "Galactose metabolism". Additionally, repro-duction, immune response, environmental adaptation were goats. The findings from our study offer profound understanding into critical features practical guidance improvement development crossbreeding initiatives different goat breeds.
Language: Английский
Citations
0
Genetics Selection Evolution, Journal Year: 2024, Volume and Issue: 56(1)
Published: July 30, 2024
Abstract Background Managing genetic diversity is critically important for maintaining species fitness. Excessive homozygosity caused by the loss of can have detrimental effects on reproduction and production performance a breed. Analysis facilitate identification signatures selection which may contribute to specific characteristics regarding health, physical appearance breed or population. In this study, breeds with well-characterized traits such as fine wool (Rambouillet, N = 745), parasite resistance (Katahdin, 581) environmental hardiness (Dorper, 265) were evaluated inbreeding, effective population size ( e ), runs (ROH) Wright’s fixation index (F ST ) outlier approach identify differential at 36,113 autosomal single nucleotide polymorphisms (SNPs). Results Katahdin sheep had largest current most recent generation estimated both GONe NeEstimator software. The highly conserved ROH Island was identified in Rambouillet signature chromosome 6 containing 202 SNPs called an 50 94% individuals. This region contained DCAF16 , LCORL NCAPG genes that been previously reported be under biological roles related milk growth traits. regions through F comparisons Dorper known mastitis susceptibility, growth, suggesting these natural artificial pressure populations. Genes involved cytokine-cytokine receptor interaction pathways all comparisons, indicates presence allelic between genomic controlling cytokine signaling mechanisms. Conclusions paper, we describe within diverse economically U.S. breeds. are proposed further study understand their relevance improve understanding diversity.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9397 - 9397
Published: Aug. 29, 2024
Hu sheep is a renowned prolific local breed in China, widely distributed across the country due to its excellent reproductive performance. Deciphering molecular mechanisms underlying high fecundity of crucial for improving litter size ewes. In this study, we genotyped 830 female using Illumina OvineSNP50 BeadChip and performed genetic diversity analysis, selection signature detection, genome-wide association study (GWAS) size. Our results revealed that population exhibits relatively diversity. A total 4927 runs homozygosity (ROH) segments were detected, with majority (74.73%) being short length. Different genomic inbreeding coefficients (
Language: Английский
Citations
3
Published: June 4, 2024
The objective of this study was to identify genomic regions and genes associated with resistance gastrointestinal nematodes in Australian Merino sheep Uruguay, using the single-step GWAS methodology (ssGWAS), which is based on estimated breeding values (GEBVs) obtained from a combination pedigree, phenotypic data. This converts GEBVs into SNP effects. Analysis included 26,638 animals fecal egg count (FEC) records two independent parasitic cycles (FEC1 FEC2), 1,700 50K genotypes. Comparison genetic variances (gVar(%)) explained by non-overlapping 20 SNPs. For FEC1 FEC2, 18 22 windows exceeded significance threshold (gVar(%) ≥ 0.22%), respectively. strong associations were located chromosomes OAR 2, 6, 11, 21 25, for FEC2 5, 6 11. proportion variance attributed top 0.83% 1.9% 33 candidate shared between traits subjected enrichment analysis, revealing marked biological processes related immune system functions. These results contribute understanding genetics underlying parasite its implications other productive welfare animal programs.
Language: Английский
Citations
2
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(8), P. e0309023 - e0309023
Published: Aug. 16, 2024
The present study aimed to identify the selection signature associated with temperature adaptation in Iranian sheep breeds raised cold and hot environments. Illumina HD ovine SNP600K BeadChip genomic arrays were utilized analyze 114 animals from eight breeds, namely Ghezel, Afshari, Shall, Sanjabi, Lori-Bakhtiari, Karakul, Kermani, Balochi. All classified into two groups: cold-weather hot-weather based on environments which they are adapted regions where have been for many years. unbiased FST (Theta) hapFLK tests used signatures. results revealed five chromosomes 2, 10, 11, 13, 14 using test, three 14, 15 test be under groups. Further exploration of these that most overlapped genes previously identified affect heat stress, nervous system function, cell division gene expression, skin growth development, embryo skeletal hypoxia conditions, immune system. These QTLs had as being various important economic traits, such body weight, color, horn characteristics. ontology network analyses significant pathways networks distinguished climates each other. We positively selected related division, biological processes, cellular responses calcium ions, metal ions inorganic substances. This represents initial effort selective sweeps linked indigenous breeds. It may provide valuable insights involved climate sheep.
Language: Английский
Citations
2
Animals, Journal Year: 2024, Volume and Issue: 14(16), P. 2447 - 2447
Published: Aug. 22, 2024
This investigation provides a comprehensive analysis of genomic diversity and selection signatures in Zaobei beef cattle, an indigenous breed known for its adaptation to hot humid climates superior meat quality. Whole-genome resequencing was conducted on 23 compared with 46 Simmental cattle highlight genetic distinctions. Population structure confirmed the uniqueness cattle. Using methods such as DASDC v1.01, XPEHH, θπ ratio, we identified 230, 232, 221 genes through DASDC, including hard sweeps, soft linkage respectively. Coincidentally, 109 were when using XPEHH ratio methods. Together, these analyses revealed eight positive (ARHGAP15, ZNF618, USH2A, PDZRN4, SPATA6, ROR2, KCNIP3, VWA3B), which are linked critical traits heat stress adaptation, fertility, Moreover, functional enrichment showed pathways related autophagy, immune response, energy metabolism, muscle development. The insights gained from this study provide valuable knowledge breeding programs aimed at enhancing beneficial
Language: Английский
Citations
2
Genes, Journal Year: 2024, Volume and Issue: 15(7), P. 846 - 846
Published: June 27, 2024
The objective of this study was to identify genomic regions and genes associated with resistance gastrointestinal nematodes in Australian Merino sheep Uruguay, using the single-step GWAS methodology (ssGWAS), which is based on estimated breeding values (GEBVs) obtained from a combination pedigree, genomic, phenotypic data. This converts GEBVs into SNP effects. analysis included 26,638 animals fecal egg count (FEC) records two independent parasitic cycles (FEC1 FEC2) 1700 50K genotypes. comparison genetic variances (gVar(%)) explained by non-overlapping 20 SNPs. For FEC1 FEC2, 18 22 windows exceeded significance threshold (gVar(%) ≥ 0.22%), respectively. strong associations were located chromosomes OAR 2, 6, 11, 21, 25, for FEC2 5, 11. proportion variance attributed top 0.83% 1.9% 33 candidate shared between traits subjected enrichment analysis, revealing marked biological processes related immune system functions. These results contribute understanding genetics underlying parasite its implications other productive welfare animal programs.
Language: Английский
Citations
1