The mechanism of egg production improvement in laying hens before and after molting revealed by transcriptome and metabolome integration DOI Creative Commons

Mengqing Sun,

Hailing Wang,

Xinyu Zhu

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105125 - 105125

Published: April 1, 2025

The objective of this research was to examine the effects and underlying mechanisms forced molting on laying rate hens. A total ninety 500-day-old hens were randomly assigned three groups: a control group (CK), starvation (SG), recovery (RG). study evaluated follicular development in measured expression levels antioxidant, lipid, inflammatory factors their serum. Additionally, transcriptomic metabolomic analyses performed assess gene metabolic profiles findings indicated that led an increase rates, reduction closure, significant rise antioxidant enzymes such as GSH, CAT, SOD, alongside decrease MDA levels. Furthermore, there reductions blood lipid LDL, HDL, TC, TG. notable differences markers TNF-α, IL-1, IL-6. data revealed influenced activation PI3K-AKT mTOR signaling pathways, affecting fatty acid metabolism modulating associated genes. In conclusion, demonstrates is effective strategy for enhancing it provides valuable theoretical framework advancing breeding practices aimed at improving egg production.

Language: Английский

Dietary silymarin improves performance by altering hepatic lipid metabolism and cecal microbiota function and its metabolites in late laying hens DOI Creative Commons
Guo Yang-hao,

Yudong Xu,

Derun Wang

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 13, 2024

Abstract Background Liver lipid dysregulation is one of the major factors in decline production performance late-stage laying hens. Silymarin (SIL), a natural flavonolignan extracted from milk thistle, known for its hepatoprotective and lipid-lowering properties humans. This study evaluates whether SIL can provide similar benefits to A total 480 68-week-old Lohmann Pink hens were randomly assigned into 5 groups, each group consisting 6 replicates with 16 each. The birds received basal diet either without silymarin (control) or supplemented at concentrations 250, 500, 750, 1,000 mg/kg (SIL250, SIL500, SIL750, SIL1000) over 12-week period. Results CON exhibited significant rates weeks 9 12 compared initial 4 ( P = 0.042), while supplementation maintained consistent throughout > 0.05). Notably, SIL500 SIL750 groups showed higher average egg weight than during 8 0.049). had significantly daily feed intake across period < 0.05), saw marked decrease feed-to-egg ratio 0.003). Furthermore, demonstrated reductions serum ALT AST levels 0.05) triglycerides cholesterol week increasing doses also positively influenced liver enzyme expression (FASN, ACC, Apo-VLDL II, FXR, CYP7A1; altered cecal microbiota composition, enhancing species linked secondary bile acid synthesis. Targeted metabolomics identified metabolites predominantly involved thiamin metabolism that different Conclusions Our dietary could ameliorate rate late stage hens, mechanistically, this effect was via improving hepatic function achieve. Revealed potentially as regulate dysregulation. Overall, 500 best effects. Graphical

Language: Английский

Citations

5
Indoor pollution of funeral homes and potential health risk of workers: a case study in Central China DOI
Jinjun Ye, Zhengtao Ai, Lup Wai Chew

et al.

Building and Environment, Journal Year: 2025, Volume and Issue: unknown, P. 112677 - 112677

Published: Feb. 1, 2025

Language: Английский

Citations

0
Caffeic acid and chlorogenic acid mediate the ADPN-AMPK-PPARα pathway to improve fatty liver and production performance in laying hens DOI Creative Commons
Wenjie Tian, Gerard Bryan Gonzales, Hao Wang

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 3, 2025

Language: Английский

Citations

0
Dietary index for gut microbiota and its inverse association with female infertility: evidence from NHANES 2013–2018 DOI Creative Commons

Chi C. J. Cheng,

Xi He, Chunhua Zhou

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Background Infertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays crucial role in female reproductive health. This study aimed investigate association between Dietary Index for Gut Microbiota (DI-GM) and infertility. Methods We analyzed data from 8,910 participants aged 20–45 years NHANES 2013–2018 cycles. DI-GM scores were calculated based on dietary recall interviews, including 14 foods nutrients associated with Female infertility was identified through questionnaires. Weighted logistic regression models used assess relationship infertility, adjustments demographic, lifestyle, health-related covariates. Restricted cubic spline (RCS) analyses explored non-linear associations, subgroup ensured robustness of results. Results A significant negative observed (adjusted OR = 0.89, 95% CI: 0.83–0.95, p &lt; 0.001). Participants ≥6 had 40% lower risk compared those 0–3 (OR 0.60, 0.44–0.82, RCS revealed an L-shaped relationship, threshold at 5. Subgroup indicated stronger associations women education levels coronary heart disease ( P interaction &lt;0.05). Conclusion Our findings demonstrate higher score is reduced suggesting interventions targeting may offer cost-effective strategy improving Further longitudinal interventional are warranted confirm causality elucidate underlying mechanisms.

Language: Английский

Citations

0
The mechanism of egg production improvement in laying hens before and after molting revealed by transcriptome and metabolome integration DOI Creative Commons

Mengqing Sun,

Hailing Wang,

Xinyu Zhu

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105125 - 105125

Published: April 1, 2025

The objective of this research was to examine the effects and underlying mechanisms forced molting on laying rate hens. A total ninety 500-day-old hens were randomly assigned three groups: a control group (CK), starvation (SG), recovery (RG). study evaluated follicular development in measured expression levels antioxidant, lipid, inflammatory factors their serum. Additionally, transcriptomic metabolomic analyses performed assess gene metabolic profiles findings indicated that led an increase rates, reduction closure, significant rise antioxidant enzymes such as GSH, CAT, SOD, alongside decrease MDA levels. Furthermore, there reductions blood lipid LDL, HDL, TC, TG. notable differences markers TNF-α, IL-1, IL-6. data revealed influenced activation PI3K-AKT mTOR signaling pathways, affecting fatty acid metabolism modulating associated genes. In conclusion, demonstrates is effective strategy for enhancing it provides valuable theoretical framework advancing breeding practices aimed at improving egg production.

Language: Английский

Citations

0