Melatonin improves endometrial receptivity and embryo implantation via MT2/PI3K/LIF signaling pathway in sows DOI Creative Commons
Xue Qin, Menghao Yang, Yang Yu

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 4, 2025

Abstract Background Increased backfat thickness of sows in early gestation is negative to reproductive performance. Endometrial receptivity an important determinant success, but it unclear whether the effect sow on litter size associated with endometrial and melatonin treatment may have benefits. The present study seeks answer these questions through vitro vivo investigations. Results Excessive lipid deposition lower levels uterus are detrimental embryo implantation high sows. In cells treated melatonin, MT2/PI3K/LIF axis played a role reducing accumulation porcine epithelium improved receptivity. Furthermore, we found reduction lipids after eight weeks intraperitoneal administration HFD mice. Notably, caused significant collagen, increase number glands, repair pinopode structure, ultimately improving receptivity, promoting implantation, increasing Conclusions Collectively, finding reveals harmful effects highlight by enhancing metabolism uterine obese animals.

Language: Английский

Melatonin improves endometrial receptivity and embryo implantation via MT2/PI3K/LIF signaling pathway in sows DOI Creative Commons
Xue Qin, Menghao Yang, Yang Yu

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 4, 2025

Abstract Background Increased backfat thickness of sows in early gestation is negative to reproductive performance. Endometrial receptivity an important determinant success, but it unclear whether the effect sow on litter size associated with endometrial and melatonin treatment may have benefits. The present study seeks answer these questions through vitro vivo investigations. Results Excessive lipid deposition lower levels uterus are detrimental embryo implantation high sows. In cells treated melatonin, MT2/PI3K/LIF axis played a role reducing accumulation porcine epithelium improved receptivity. Furthermore, we found reduction lipids after eight weeks intraperitoneal administration HFD mice. Notably, caused significant collagen, increase number glands, repair pinopode structure, ultimately improving receptivity, promoting implantation, increasing Conclusions Collectively, finding reveals harmful effects highlight by enhancing metabolism uterine obese animals.

Language: Английский

Citations

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