Treatment of Qin Gui Wan (QGW) in PCOS abnormal oocytes development via AMPK / PGC-1ɑ pathway

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 342, P. 119434 - 119434

Published: Jan. 31, 2025

Language: Английский

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Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 26, 2025

Abstract The battle against cancer has evolved over centuries, from the early stages of surgical resection to contemporary treatments including chemotherapy, radiation, targeted therapies, and immunotherapies. Despite significant advances in treatment recent decades, these therapies remain limited by various challenges. Immune checkpoint inhibitors (ICIs), a cornerstone tumor immunotherapy, have emerged as one most promising advancements treatment. Although ICIs, such CTLA-4 PD-1/PD-L1 inhibitors, demonstrated clinical efficacy, their therapeutic impact remains suboptimal due patient-specific variability immune resistance. Cell death is fundamental process for maintaining tissue homeostasis function. Recent research highlights that combination induced regulatory cell (RCD) ICIs can substantially enhance anti-tumor responses across multiple types. In cells exhibiting high levels recombinant solute carrier family 7 member 11 (SLC7A11) protein, glucose deprivation triggers programmed (PCD) pathway characterized disulfide bond formation REDOX (reduction-oxidation) reactions, termed “disulfidptosis.” Studies suggest disulfidptosis plays critical role efficacy SLC7A11 cancers. Therefore, investigate potential synergy between this study will explore mechanisms both processes progression, with goal enhancing response targeting intracellular pathway.

Language: Английский

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Bioactivity and biomedical applications of pomegranate peel extract: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Pomegranate peel is a by-product generated during the processing of pomegranate ( Punica granatum L.) fruit, accounting for approximately 50% total mass fruit. Although usually regarded as waste, it rich in various bioactive metabolites such polyphenols, tannins, and flavonoids, demonstrating significant medicinal nutritional value. In recent years, extract (PPE) has shown broad application prospects biomedical field due to its multiple effects, including antioxidant, anti-inflammatory, antibacterial, anti-apoptotic properties, promotion cell regeneration. This review consolidates major PPE explores applications materials, nanodrug carriers, hydrogels, tissue engineering scaffolds. By synthesizing existing literature, we delve into potential value biomedicine, challenges currently encountered, future directions research. The aim this provide scientific basis optimizing utilization facilitate broader field.

Language: Английский

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Lonicerin regulates AMPK/SIRT1/autophagy pathway to attenuate heat stress intestinal injury and inhibit inflammation

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114549 - 114549

Published: March 31, 2025

Language: Английский

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Rutin Ameliorates BHBA-Induced Inflammation and Lipid Accumulation in Calf Hepatocytes Through NF-κB Signaling Pathway

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 274 - 274

Published: April 14, 2025

When subclinical ketosis (SCK) occurs in dairy cows, it leads to an excessive production of β-hydroxybutyrat (BHBA), which disrupts liver lipid metabolism and triggers a series inflammatory responses. Rutin (RT), flavonoid extracted from plants, exhibits diverse biological activities. However, its potential mitigate BHBA-induced inflammation accumulation cows remains unexplored. In this study, we investigated the effect RT on injury hepatocytes possible mechanism. First, were treated with BHBA (0, 0.3, 0.6, 1.2, 2.4 mM) assess effects impairment accumulation. Second, pretreated 25, 50, 100, 150 μg/mL) evaluate protective effects. Third, divided into five treatment groups: blank control, treatment, + NF-κB activator (PDTC) PDTC treatment. This experiment further explored underlying mechanism mitigating hepatocyte injury. The results demonstrated that at 100 μg/mL mitigated increases interleukin-1 beta (IL-1β), IL-6, triglyceride (TG), total cholesterol (TC) contents induced by high concentrations (p < 0.05). Compared significantly downregulated relative protein expression P-NF-κB p65 mRNA p65, tumor necrosis factor-alpha (TNF-α), IL-1β, peroxisome proliferator-activated receptor gamma (PPARγ), microsomal transfer (MTP), while upregulating IKBα Additionally, these more pronounced combined pretreatment RT. conclusion, inhibits BHBA-triggered modulating signaling pathway, implying may be promising target for ameliorating damage SCK cows.

Language: Английский

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The role of granulosa cells in oocyte development and aging: Mechanisms and therapeutic opportunities

Seminars in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 171, P. 103614 - 103614

Published: April 28, 2025

Language: Английский

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