Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 15, 2024
Pyroptosis
is
a
lytic
and
inflammatory
form
of
gasdermin
protein-mediated
programmed
cell
death
that
typically
initiated
by
inflammasomes.
The
inflammasome
response
an
effective
mechanism
for
eradicating
germs
cancer
cells
in
the
event
cellular
injury.
family
responsible
initiating
pyroptosis,
process
which
holes
are
made
membrane
to
allow
chemicals
escape.
Mounting
evidence
indicates
pyroptosis
critical
controlling
development
cancer.
In
this
review,
we
provide
general
overview
examine
relationship
between
primary
elements
tumors,
stress
necessity
pyroptosis-targeted
therapy
tumors.
Furthermore,
explore
its
dual
nature
as
double-edged
sword
capable
both
inhibiting
facilitating
growth
cancer,
depending
on
specific
conditions.
Ultimately,
phenomenon
has
positive
negative
effects
Using
impact
reasonable
manner
may
facilitate
investigation
into
initiation
progression
tumors
offer
insights
novel
treatments
centered
pyroptosis.
Experimental Hematology and Oncology,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: July 16, 2024
Abstract
Nuclear
factor-kappaB
(NF-ĸB)
plays
a
crucial
role
in
both
innate
and
adaptive
immune
systems,
significantly
influencing
various
physiological
processes
such
as
cell
proliferation,
migration,
differentiation,
survival,
stemness.
The
function
of
NF-ĸB
cancer
progression
response
to
chemotherapy
has
gained
increasing
attention.
This
review
highlights
the
inflammation
control,
biological
mechanisms,
therapeutic
implications
treatment.
is
instrumental
altering
release
inflammatory
factors
TNF-α,
IL-6,
IL-1β,
which
are
key
regulation
carcinogenesis.
Specifically,
conditions
including
colitis,
upregulation
can
intensify
inflammation,
potentially
leading
development
colorectal
cancer.
Its
pivotal
extends
regulating
tumor
microenvironment,
impacting
components
macrophages,
fibroblasts,
T
cells,
natural
killer
cells.
influences
tumorigenesis
dampen
anti-tumor
responses.
Additionally,
modulates
death
notably
by
inhibiting
apoptosis
ferroptosis.
It
also
dual
stimulating
or
suppressing
autophagy
cancers.
Beyond
these
functions,
controlling
stem
fostering
angiogenesis,
metastatic
potential
through
EMT
induction,
reducing
sensitivity
radiotherapy.
Given
its
oncogenic
capabilities,
research
focused
on
products
small
molecule
compounds
that
suppress
NF-ĸB,
offering
promising
avenues
for
therapy.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Nov. 30, 2024
In
the
realm
of
cancer
research,
tumor
microenvironment
(TME)
plays
a
crucial
role
in
initiation
and
progression,
shaped
by
complex
interactions
between
cells
surrounding
non-cancerous
cells.
Cytokines,
as
essential
immunomodulatory
agents,
are
secreted
various
cellular
constituents
within
TME,
including
immune
cells,
cancer-associated
fibroblasts,
themselves.
These
cytokines
facilitate
intricate
communication
networks
that
significantly
influence
initiation,
metastasis,
suppression.
Pyroptosis
contributes
to
TME
remodeling
promoting
release
pro-inflammatory
sustaining
chronic
inflammation,
impacting
processes
such
escape
angiogenesis.
However,
challenges
remain
due
interplay
among
cytokines,
pyroptosis,
along
with
dual
effects
pyroptosis
on
progression
therapy-related
complications
like
cytokine
syndrome.
Unraveling
these
complexities
could
strategies
balance
inflammatory
responses
while
minimizing
tissue
damage
during
therapy.
This
review
delves
into
crosstalk
elucidating
their
contribution
metastasis.
By
synthesizing
emerging
therapeutic
targets
innovative
technologies
concerning
this
aims
provide
novel
insights
enhance
treatment
outcomes
for
patients.
Cells,
Journal Year:
2024,
Volume and Issue:
13(3), P. 233 - 233
Published: Jan. 25, 2024
IL-1
family
members
have
multiple
pleiotropic
functions
affecting
various
tissues
and
cells,
including
the
regulation
of
immune
response,
hematopoietic
homeostasis,
bone
remodeling,
neuronal
physiology,
synaptic
plasticity.
Many
these
activities
are
involved
in
pathological
processes
immunological
disorders,
tumor
initiation
progression.
Indeed,
been
described
to
contribute
shaping
microenvironment
(TME),
determining
evasion
drug
resistance,
sustain
aggressiveness
metastasis.
This
review
addresses
role
sarcomas,
particularly
highly
metastatic
osteosarcoma
(OS)
Ewing
sarcoma
(EWS),
discusses
IL-1-family-related
mechanisms
that
play
a
metastasis
development.
We
also
consider
therapeutic
implications
targeting
members,
which
proposed
as
(i)
relevant
targets
for
anti-tumor
anti-metastatic
drugs;
(ii)
checkpoints
suppression;
(iii)
potential
antigens
immunotherapy.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
This
chapter
explores
how
to
regulate
programmed
cell
death
and
its
relevance
in
cancer
therapy.
It
points
the
need
of
investigate
mechanisms
death,
like
apoptosis,
necroptosis,
and,
more
recently,
exposed
ferroptosis,
while
creating
approaches
for
treatment
malignant
diseases.
In
spite
progress
field
targeted
therapies,
is
still
a
main
cause
due
incapability
cells
undergo
apoptosis.
The
highlights
significance
adopting
complex
that
encompass
multiple
types
occurring
within
both
tumor
microenvironment.
Of
note
are
functions
oncogenes
suppressor
genes
regulation
cellular
processes,
specific
role
apoptosis
formation
process,
possibility
increase
neoplastic
cells.
There
metastasis
critical
such
as
TP53
gene,
along
with
presence
an
over
expression
anti-apoptotic
proteins.
Examples
this
would
include
Bcl-2
IAPs,
which
protect
against
stimuli
required
death.
immunotherapy
combination
therapies
described
emerging
strategies
enhance
efficacy
treatments.
document
also
deals
problem
resistance
induction
necessity
further
clinical
studies
new
therapeutic
agents
practice.
summary,
it
diversity
biology
paradigm
shift
achieve
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 26, 2025
Oral
squamous
cell
carcinoma
(OSCC)
represents
a
significant
global
health
challenge,
characterized
by
aggressive
progression
and
poor
therapeutic
response
despite
advances
in
treatment
modalities.
This
review
provides
comprehensive
analysis
of
diverse
death
mechanisms
OSCC,
encompassing
traditional
pathways
(apoptosis,
autophagy,
necrosis),
newly
(ferroptosis,
pyroptosis,
necroptosis),
emerging
(cuproptosis,
anoikis,
parthanatos,
entosis).
By
examining
the
molecular
basis
these
pathways,
particularly
crucial
roles
p53
signaling
miRNA
regulation,
we
highlight
how
their
dysregulation
contributes
to
resistance
tumor
progression.
The
synthesizes
recent
evidence
demonstrating
complex
interplay
between
ten
distinct
impact
on
microenvironment
immune
response.
We
evaluate
innovative
approaches
that
target
including
novel
small
molecules,
combination
strategies,
immunomodulatory
treatments
exploit
specific
enhance
efficacy.
Special
attention
is
given
personalized
medicine
strategies
consider
individual
characteristics
pathway
profiles.
integrating
current
challenges
with
future
research
directions,
this
framework
for
developing
more
effective
can
leverage
multiple
overcome
therapy
improve
outcomes
oral
cancer
patients.
