Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer DOI Creative Commons
Eunjin Kook,

Do‐Hee Kim

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 309 - 309

Published: May 28, 2024

Lipids, as multifunctional molecules, play a crucial role in variety of cellular processes. These include regulating membrane glycoprotein functions, controlling trafficking, influencing apoptotic pathways, and affecting drug transport. In addition, lipid metabolites can alter the surrounding microenvironment ways that might encourage tumor progression. The reprogramming metabolism is pivotal promoting tumorigenesis cancer progression, with tumors often displaying significant changes profiles. This review concentrates on essential factors drive metabolic reprogramming, which contributes to advancement resistance melanoma. Moreover, we discuss recent advances current therapeutic strategies employ small-molecule inhibitors target skin cancers, particularly those associated inflammation

Language: Английский

Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer DOI Creative Commons
Xue‐Yuan Bi, Jihan Wang, Cuicui Liu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 917 - 917

Published: July 27, 2024

Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores interplay between intratumoral microbiota, tumor metabolism, major types GI (including esophageal, gastric, liver, pancreatic, colorectal cancers), summarizing recent studies elucidating clinical implications future directions. Recent research revealed altered microbial signatures within tumors, impacting progression, immune responses, outcomes. Dysbiosis-induced alterations in including glycolysis, fatty acid amino play critical roles cancer progression therapeutic resistance. The integration molecular mechanisms potential biomarkers into this further enhances prognostic significance microbiota composition opportunities targeting microbiota-mediated metabolism. Despite advancements, challenges remain dynamic interactions microenvironment (TME). Future directions, advanced omics technologies prospective studies, offer promising avenues precision oncology personalized interventions cancer. Overall, integrating microbiota-based approaches management holds promise improving patient outcomes survival.

Language: Английский

Citations

3
Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment DOI Open Access
Durre Aden, Niti Sureka, Samreen Zaheer

et al.

Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

ABSTRACT Cancer is a complex and heterogeneous disease characterised by uncontrolled cell growth proliferation. One hallmark of cancer cells their ability to undergo metabolic reprogramming, which allows them sustain rapid survival. This reprogramming creates an immunosuppressive microenvironment that facilitates tumour progression evasion the immune system. In this article, we review mechanisms underlying in discuss how these alterations contribute establishment microenvironment. We also explore potential therapeutic strategies targeting vulnerabilities enhance immune‐mediated anti‐tumour responses. Trial Registration ClinicalTrials.gov identifier: NCT02044861, NCT03163667, NCT04265534, NCT02071927, NCT02903914, NCT03314935, NCT03361228, NCT03048500, NCT03311308, NCT03800602, NCT04414540, NCT02771626, NCT03994744, NCT03229278, NCT04899921

Language: Английский

Citations

3
Towards the preparation of smart drug delivery platforms for colorectal cancer therapy: Biocompatible and targeted mesoporous silica nanoparticles with the deferiprone-copper complex gatekeeper DOI

Sonia Iranpour,

Khalil Abnous, Seyed Mohammad Taghdisi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106087 - 106087

Published: Aug. 23, 2024

Language: Английский

Citations

2
Esterase-responsive nanoparticles (ERN): A targeted approach for drug/gene delivery exploits DOI

Ashok Kumar Madikonda,

Amritha Ajayakumar,

Sudeena Nadendla

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 116, P. 118001 - 118001

Published: Nov. 14, 2024

Language: Английский

Citations

2
Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer DOI Creative Commons
Eunjin Kook,

Do‐Hee Kim

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 309 - 309

Published: May 28, 2024

Lipids, as multifunctional molecules, play a crucial role in variety of cellular processes. These include regulating membrane glycoprotein functions, controlling trafficking, influencing apoptotic pathways, and affecting drug transport. In addition, lipid metabolites can alter the surrounding microenvironment ways that might encourage tumor progression. The reprogramming metabolism is pivotal promoting tumorigenesis cancer progression, with tumors often displaying significant changes profiles. This review concentrates on essential factors drive metabolic reprogramming, which contributes to advancement resistance melanoma. Moreover, we discuss recent advances current therapeutic strategies employ small-molecule inhibitors target skin cancers, particularly those associated inflammation

Language: Английский

Citations

1