A novel hypoxia-induced lncRNA, SZT2-AS1, boosts HCC progression by mediating HIF heterodimerization and histone trimethylation under a hypoxic microenvironment DOI
Runkun Liu, Yixian Guo, Liang Wang

et al.

Cell Death and Differentiation, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Language: Английский

Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies DOI Creative Commons
Siwei Zheng,

Wenwen Wang,

Lesang Shen

et al.

Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)

Published: Aug. 6, 2024

Abstract The tumor microenvironment demonstrates great immunophenotypic heterogeneity, which has been leveraged in traditional immune-hot/cold categorization based on the abundance of intra-tumoral immune cells. By incorporating spatial contexture, immunophenotype was further elaborated into immune-inflamed, immune-excluded, and immune-desert. However, mechanisms underlying these different phenotypes are yet to be comprehensively elucidated. In this review, we discuss how cells interact collectively shape landscape from perspectives cells, extracellular matrix, cancer metabolism, summarize potential therapeutic options according distinct immunophenotypes for personalized precision medicine.

Language: Английский

Citations

14
Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections DOI Creative Commons
Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas

et al.

Open Biology, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

Glycolysis, present in most organisms, is evolutionarily one of the oldest metabolic pathways. It has great relevance at a physiological level because it responsible for generating ATP cell through conversion glucose into pyruvate and reducing nicotinamide adenine dinucleotide (NADH) (that may be fed electron chain mitochondria to produce additional by oxidative phosphorylation), as well producing intermediates that can serve substrates other processes. Glycolysis takes place 10 consecutive chemical reactions, each which catalysed specific enzyme. Although energy transduction metabolism main function this pathway, involvement virulence, growth, pathogen–host interactions, immunomodulation adaptation environmental conditions are functions attributed pathway. In humans, where glycolysis occurs mainly cytosol, mislocalization some glycolytic enzymes various subcellular locations, alterations their expression regulation, been associated with development progression diseases. review, we describe role pathogenesis diseases clinical interest. addition, potential these targets drug use diagnostic prognostic markers pathologies also discussed.

Language: Английский

Citations

0
Single-Cell Sequencing Reveals the Role of Radiation-Induced Stemness-Responsive Cancer Cells in the Development of Radioresistance DOI Open Access
Zheng Shi,

Cuilan Hu,

Jiadi Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1433 - 1433

Published: Feb. 8, 2025

Increased stemness of cancer cells exacerbates radioresistance, thereby greatly limiting the efficacy radiotherapy. In order to study changes in cell during radiotherapy, we established a radioresistance model human non-small lung A549 and obtained radioresistant (A549-RR). We sampled at different time points modeling process investigated heterogeneity each group using single-cell sequencing. Cells early stages fractionated irradiation were found be significantly up-regulated stemness, subpopulation producing this response was screened referred as "radiation-induced stemness-responsive cells". They undergoing response, energy metabolism reprogramming, progressively differentiating into with more diverse malignant phenotypes attenuate killing effect radiation. Furthermore, demonstrated that such responses might driven by activation EGFR-Hippo signaling pathway axis, which also plays crucial role development radioresistance. Our reveals dynamic evolution radiotherapy; stage can determine destiny radiation-induced cells. The stemness-like is not result dose accumulation but occurs radiotherapy relatively low-dose irradiation. degree mediated potential predictor

Language: Английский

Citations

0
Unveiling Novel Targets in Lung Tumors for Enhanced Radiotherapy Efficacy: A Comprehensive Review DOI Open Access

Faris Anad Muhammad,

Ayat Hussein Adhab,

Morug Salih Mahdi

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 23, 2025

ABSTRACT Radiotherapy is a cornerstone of lung cancer management, though its efficacy frequently undermined by intrinsic and acquired radioresistance. This review examines the complexity tumors, highlighting their potential as reservoir novel targets for radiosensitization. Ionizing radiation (IR) primarily exerts effects through oxidative damage DNA double‐strand breaks (DSBs). Lung cells, however, develop mutations that enhance response (DDR) suppress cell death pathways. Additionally, interactions between tumor cells microenvironment (TME) components—including immune stromal molecular mediators such cytokines, chemokines, growth factors—contribute to resistance against IR. Understanding these intricate relationships reveals improve radiotherapy outcomes. Promising include DDR pathways, immunosuppressive molecules, hypoxia, proangiogenic mediators, other key signaling discusses emerging strategies, combining with immunomodulators, hypoxia inhibitors, DDR‐targeting agents, innovative approaches. By offering comprehensive analysis TME, this underscores opportunities effectiveness targeted radiosensitization strategies.

Language: Английский

Citations

0
Establishment and transcriptomic characteristics of radio-resistant meningioma cell lines DOI
Jinxiu Yu,

Leihao Ren,

Tianqi Wu

et al.

Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

Citations

0
Exploring the molecular mechanism of cancer radiosensitization: the impact of physical stimulation therapy DOI
Shun Liu, Mingjie Li,

Zhili Guo

et al.

Strahlentherapie und Onkologie, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

0
Hypoxia and intrinsic radiosensitivity: Exploring mechanisms in radiation resistance of cancers and biomarkers for enhanced treatment strategies DOI
Elham Khakshour,

Mohammad Amin Shahram,

Reza Chaman

et al.

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101450 - 101450

Published: April 3, 2025

Language: Английский

Citations

0
GLS2 inhibition synergizes with copper to reprogram TCA cycle for cuproptosis-driven radiosensitization in esophageal cancer DOI Creative Commons
Jing Wang, Wenhao Wang, Yi Ding

et al.

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 10, 2025

Abstract Esophageal squamous cell carcinoma (ESCC) is notorious for its poor prognosis. In the present study, role of glutaminase 2 (GLS2) and copper (Cu) in radiosensitivity ESCC was explored. Both vitro vivo experiments were conducted, results demonstrated that knockdown GLS2 could suppress proliferation augment sensitivity to radiotherapy (RT). The addition Cu influenced viability radiosensitivity. Notably, under normal expression status, exogenous augmented RT without triggering cuproptosis. Mechanistically, suppression interacted with downregulate lipoic acid synthase dihydrolipoamide S-succinyltransferase, resulting reduction activity α-ketoglutarate dehydrogenase complex obstruction tricarboxylic cycle, ultimately leading enhancement sensitivity. These findings emphasize significance cuproptosis provide potential directions therapeutic strategies.

Language: Английский

Citations

0
Cancer Cell Membrane-Coated siRNA-Decorated Au/MnO2 Nanosensitizers for Synergistically Enhanced Radio-Immunotherapy of Breast Cancer DOI Creative Commons

Diyu Wang,

Subin Lin,

Tuanwei Li

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101275 - 101275

Published: Sept. 27, 2024

Language: Английский

Citations

2
Hypoxia-induced SZT2-AS1 is required for HIF-1 heterodimer formation and histone trimethylation in HCC cells under hypoxic microenvironment DOI Creative Commons
Yufeng Wang, Runkun Liu, Yixian Guo

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

Abstract Hypoxic microenvironment plays a critical role in solid tumor growth, metastasis and angiogenesis. Hypoxia-inducible factors (HIFs), which are canonical transcription response to hypoxia, stabilized under hypoxia they coordinate the process of hypoxia-induced gene expression leading cancer progression. Increasing evidence has indicated that long noncoding RNAs (lncRNAs) closely associated with play crucial roles hypoxia-mediated HCC progression, while mechanisms largely unknown. Here, we identified novel lncRNA SZT2-AS1 HCC, was induced by HIF-1-dependent manner promoted The clinical data level substantially upregulated significantly poor outcomes, acted as an independent prognostic predictor. Mechanistically, SZT2-AS1, turn, recruited HIF-1α HIF-1β form HIF-1 heterodimer. And required for occupancy elements (HREs) HIF target transcription. In addition, histone trimethylation (H3K4me3 H3K36me3) at HREs. Through recruiting methyltransferase SMYD2, modification H3K4 H3K36 cells. Taken together, our results uncovered lncRNA-involved positive feedback mechanism established value prognosis potential therapeutic strategy HCC. Significance: LncRNA involves provides

Language: Английский

Citations

0