PubMed, Journal Year: 2024, Volume and Issue: 44(11), P. 2131 - 2136
Published: Nov. 20, 2024
To investigate the expression of Acyl-CoA synthetase long-chain family member 4 (ACSL4) in liver cancer and its role regulating ferroptosis proliferation cells.
Language: Английский
Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(5)
Published: March 27, 2025
Language: Английский
Citations
0
Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16
Published: April 7, 2025
The role of immunogenic cell death (ICD) in cervical cancer (CESC) is not well understood. This study sought to investigate the significance ICD CESC and establish an ICDRs prognostic model improve immunotherapy efficacy for patients with cancer. ICD-associated genes were screened at single-cell transcriptome levels based on AddModuleScore, single-sample gene set enrichment analysis (ssGSEA) weighted co-expression network (WGCNA) analysis. Immunogenic death-related features (ICDRs) constructed using multiple machine algorithms, evaluated training validation sets provide quantitative tools predicting prognosis clinical practice. Predictive models used risk subgroups response immunotherapy, as drug sensitivity. Finally, expression ICD-related was verified by RT-qPCR. Through integrated data, transcriptomic profiling, computational modeling, seven identified highly patients. Multivariate demonstrated that low-risk had significantly better overall survival compared high-risk patients, confirming independent tool. Assessments tumor microenvironment (TME), mutation characteristics, sensitivity within indicated a stronger group.
Language: Английский
Citations
0
Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 24, 2025
Language: Английский
Citations
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Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 28, 2025
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with pressing need for effective biomarkers and therapeutic targets. Despite the clinical use alpha-fetoprotein (AFP) as diagnostic biomarker, its limitations in sensitivity specificity necessitate identification novel markers. In this study, we investigated role Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC) HCC prognosis potential target. Utilizing spatial transcriptomics single-cell RNA sequencing (scRNA-seq), dissected cellular composition PRKDC tissue samples, revealing high expression malignant cell subpopulations association tumor immune microenvironment. Through signature analysis, observed widespread tissues, particularly cells, highlighting link to infiltration. Further analyses confirmed cells inhibitory effect on Copy number variation (CNV) analysis revealed significant genomic instability, exhibiting both amplifications deletions across chromosomal regions, underscoring tumorigenesis. Functional overexpression lines enhanced proliferation, migration, altered cycle dynamics, notable increase G2/S phase. Taken together, first integrate bulk RNA-seq reveal that reliable prognostic biomarker High associated shorter survival times an abnormal microenvironment, impact infiltration prognosis. Targeting could selectively inhibit providing new strategies treatment.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1407 - 1407
Published: Nov. 5, 2024
Ferroptosis, a recently elucidated style of regulated cell death, has emerged as significant area investigation in cancer biology. Natural active compounds that have anti-cancer effects are promising candidates for prevention. Iberverin, natural compound derived from
Language: Английский
Citations
3
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Nov. 28, 2024
Cancer vaccines have garnered attention as a potential treatment for cancer metastases. Nevertheless, the clinical response rate to remains < 30%. Nanoparticles stabilize and improve antigen recognition presentation, resulting in high tumor penetration or accumulation, effective co-distribution of drugs secondary lymphatic system, adaptable adjuvant administration. Such vaccine-like nanomedicines ability eradicate primary tumors well prevent eliminate This review examines state-of-the-art nanocarriers developed deliver metastases, including synthetic, semi-biogenic, biogenic nanosystems. Moreover, it highlights physical pharmacological properties that enhance their anti-metastasis efficiency. also addresses combination nanovaccines with immunotherapy target various steps metastatic cascade, drawing insights from preclinical studies. The concludes critical analysis challenges frameworks linked translation nanovaccines.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11676 - 11676
Published: Oct. 30, 2024
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and third leading cause of cancer-related death worldwide. Liver transplantation (LT) best therapy for patients with non-metastatic HCC. In recent years, management HCC has considerably changed, thanks to improvement molecular biology knowledge introduction immunotherapy. To date, systemic authorized in Western world only advanced However, this could not stabilize tumour disease or improve survival but display excellent response lead downstaging that finally permits LT. There are increasing reports have performed LT after pretreatment immune checkpoint inhibitors (ICIs). due intrinsic mechanism ICIs, graft rejection might be favoured. addition, chronic adverse effects affecting other organs may also appear end therapy. This review aims evaluate readiness outcomes who previously undergone treatment ICIs. It seeks identify challenges, risks, benefits associated conversion The integration ICIs into paradigm necessitates a nuanced approach While early evidence supports feasibility following therapy, there an urgent need standardized guidelines more extensive longitudinal studies optimize patient selection, timing, post-transplant management.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 29, 2024
Hepatocellular carcinoma is the predominant histologic variant of hepatic malignancy and has become a major challenge to global health. The increasing incidence mortality hepatocellular created an urgent need for effective prevention, diagnosis, treatment strategies. This despite impressive results multiple treatments in clinic. However, unique tumor immunosuppressive microenvironment increases difficulty immune tolerance. In recent years, application nanoparticles brought new hope patients. Nano agents target tumor-associated fibroblasts, regulatory T cells, myeloid suppressor macrophages, neutrophils, immature dendritic reversed carcinoma. addition, he purpose this review summarize advantages nanotechnology guiding surgical excision, local ablation, TACE, standard chemotherapy, immunotherapy, nano-vaccines also continuously enriched liver cancer. study aims investigate potential applications management carcinoma, with ultimate goal enhancing therapeutic outcomes improving prognosis patients affected by malignancy.
Language: Английский
Citations
1
Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 860 - 860
Published: Oct. 24, 2024
Cell adhesion regulates specific migratory patterns, location, communication with other cells, physical interactions the extracellular matrix, and establishment of effector programs. Proper immune control cancer strongly depends on all these events occurring in a highly accurate spatiotemporal sequence. In response to cancer-associated inflammatory signals, cells navigating bloodstream shift from their patrolling exploratory migration mode establish adhesive vascular endothelial cells. This interaction enables them extravasate through blood vessel walls access site. Further within tumor microenvironment (TME) are crucial for coordinating distribution situ mounting an effective anti-tumor response. this review, we examine how alterations cues context favor escape by affecting cell infiltration trafficking TME. We discuss mechanisms which tumors directly modulate patterns affect immunity evasion. also explore indirect that involve modifications TME characteristics, such as vascularization, immunogenicity, structural topography. Finally, highlight significance aspects designing more drug treatments cellular immunotherapies.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 28, 2024
Abstract Background The prognosis for hepatocellular carcinoma (HCC) patients can vary significantly even within the same clinical stage. This study aims to characterize stage-specific transcriptomic landscape of super survivors with HCC and identify a prognostic gene signature. Methods We analyzed data from Cancer Genome Atlas (TCGA) 76 matched (alive at 5 years) poor (deceased 1 year) HCC. Gene set enrichment analysis stratified by stage was conducted key signature developed. then applied full TCGA cohort independently validated in International Consortium (ICGC) data. Findings Stage-specific profiling revealed distinct patterns survivors. Stage I II showed positive immune response pathways, while III exhibited enhanced catabolic activities reduced glycolysis. Across all stages, cell cycle processes were less active A 19-gene signature, incorporating immune, metabolic, genes, accurately distinguished 91% accuracy (69/76). reliably predicted overall survival both verification (1-year, 3-year, 5-year AUROCs 0.82, 0.80, 0.78) independent validation (1-year 3-year 0.80 0.83). Consistent observed across tumor stages. Interpretation Our findings reveal dynamic shift progression, dominance early stages metabolic later alongside activity Integrating profiles offers promising approach enhancing individualized management patients.
Language: Английский
Citations
0